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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 379 for “"axons"”.
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Diffuse axonal injury effect on myelinating cells and axons
… able to remain healthy in culture to have their axons myelinated. Dorsal root ganglion (DRG) neurons have been shown to be myelinated by cortical oligodendrocytes in culture. An in vitro stretch injury model was used to analyze the DRG axon pathology during and after injury. DRG myelinating …
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Towards understanding the mechanisms behind mRNA localisation in growing axons
… localisation is precisely regulated in growing axons, affording subcellular autonomy by allowing controlled protein expression in space and time. Different sets of mRNAs exhibit different localisation patterns across the axon. Little is known, however, about how mRNAs move in axons, or how these …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… in MS and relevant disease models, demyelinated axons harbor an increased number of mitochondria, which is reflected in bigger stationary sites of mitochondria, increased mitochondrial activity and increased transport speed of mitochondria. This axonal response of mitochondria to demyelination …
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Studies on Fast Axoplasmic Transport: Differential Transport of Protein in Axons
Made available in DSpace on 2014-12-10T23:24:30Z (GMT). No. of bitstreams: 1 7405521.pdf: 5583870 bytes, checksum: 9418d571c54a446866a64d4d6b4f2131 (MD5) Previous issue date: 1973
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A modeling study of the history-dependence of conduction delay in unmyelinated axons
Conduction delay in an axon is the time required for an action potential to propagate between two positions. It is a function of the axon's passive membrane properties, voltage-gated ion channels and the Na+/K+ pump, and can be substantially affected by neuromodulators. The conduction delay of …
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Mechanics of living cells: nonlinear viscoelasticity of single fibroblasts and shape instabilities in axons
… performed on neurites. These comprise axons --the processes extended by neurons-- as well as PC12 neurites, a model system for axons. After a sudden increase in the external osmotic pressure, axons swell and a cylindrical-peristaltic shape transformation sets in. We interprete this …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
… successfully achieved separation of axons from the soma and allows tracking of transport along oriented axons. To create an in vitro model of PD, dopaminergic axons from midbrain cultures were isolated within the microchannels away from the cell bodies. To determine the best method …
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Regulation of Polarized Protein Transport to Axons, Dendrites, and Sensory Cilia in Caeborhabditis Elegans Neurons
… mechanisms that direct polarized transport to axons, dendrites and cilia in neurons are only partly understood. In this thesis, I describe my effort at understanding how neuronal proteins are asymmetrically localized. I pursued a genetic approach, employing the C. elegans nervous system as an …
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The Guidance of Olfactory Sensory Axons to Identifiable Protoglomeruli in the Larval Zebrafish Olfactory Bulb
… neurons in the olfactory epithelium extend axons into the olfactory bulb. The earliest axons to enter the bulb terminate onto distinct neuropilar condensations called protoglomeruli. Protoglomeruli are thought to segregate into individual glomeruli later in development. The three day old …
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Ultrastructural correlates of axons and synapses belonging to different circuits in ferret primary visual cortex
<p>The goal of this study was to determine differences in distinctive layers of mammalian primary visual cortex through analysis of their ultrastructural characteristics. Characterizing brain circuitry using 3-dimensional reconstruction of electron microscopy images, and subsequent ultrastructural …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
… along gastrocnemius-associated motorneuron axons. We first measured accumulation of the retrogradely transported phosphorylated neurofilament-H (NF-H-P) protein at distal motorneuron axons in young (30 day old; 30d) and young-adult (120d) transgenic mice. We show significant accumulation of …
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
… as oligodendrocytes wrap myelin around neuronal axons, forming an insulative sheath that accelerates signal propagation down the axon. A major obstacle to understanding myelination is the challenge of visualizing and reproducibly quantifying this inherently three-dimensional process in vitro. To …
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Regenerative growth of axons of hamster optic tract : effects of age, substrate, and growth-promoting factors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1989.
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Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors Dcc and Neogenin
<p>During neurodevelopment, commissural axons are guided to the ventral midline in a remarkably precise and stereotyped way. Netrin, a secreted laminin-related protein, provides the major attractive cue for midline guidance. It is thought to act at long-range, functioning either in solution …
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Descending Activation of Cockroach Giant Axons and Alterations of Their Conduction Velocity by the Local Anaesthetic-Like Activity of Nicotine
Made available in DSpace on 2015-05-14T14:58:35Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7317540.PDF: 6948398 bytes, checksum: 952b733917dcf56626507b34f6162b2d (MD5) Previous issue date: 1973
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Morphometric characterization of individual sympathetic postganglionic axons innervating the muscle layers of the gastrointestinal tract of the rat: A complex effector model
… morphology of sympathetic postganglionic axons innervating the musculature of the gastrointestinal (GI) tract has not been available. Furthermore, common assumptions about the morphology and distribution of catecholaminergic terminal fields have been strongly shaped by the limitations of …
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Quantitative analysis of axon elongation : a novel application of stochastic modeling techniques to long-term, high-resolution time-lapse microscopy of cortical axons
Axons exhibit a rich variety of behaviors, such as elongation, turning, branching, and fasciculation, all in service of the complex goal of wiring up the brain. In order to quantify these behaviors, I have developed a system for in vitro imaging of axon growth cones with time-lapse fluorescence …
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Axon-glia interactions during central nervous system myelination
… speeds up action potential propagation along axons, which is fundamental for the correct function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control myelination, as …
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