Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"axonal regeneration"”.
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Promoting bridging axonal regeneration after spinal cord injury
… the extent to which OECs promote long distance axonal regeneration when transplanted into spinal cord lesions. In the first chapter of Results (chapter 3) we aimed to determine the potential of OEC transplantation in promoting axonal regeneration beyond the injury. This was investigated by …
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Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
… higher vertebrates, the lamprey displays robust axonal regeneration in the central nervous system following neural injuries. For example, following spinal cord transections, the descending axons of brain neurons regenerate and reconnect with spinal targets so that locomotor behavior recovers in a …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… evaluated the potential impact of CXB-NE on neuroregeneration. In CCI, the injury and inflammation damages nerves, leading to axon degeneration distal from the site of injury. While peripheral nerves can regenerate axons, if axonal degeneration continues to occur due to inflammation, then axonal …
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Thick Conducting Polymer Coatings for Safe Electric Field Delivery to the Spinal Cord
… has emerged as a promising approach to promote axonal regeneration after SCI, yet clinical translation has been constrained by the electrochemical and mechanical limitations of conventional metal electrodes. This thesis addresses these challenges by establishing a quantitative and operational …
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Investigation of minimum fragment requirement for mimicking n-cadherin mediated adhesion
… that N-cadherins can promote neuronal growth and axonal regeneration in vitro. Moreover, there is a growing interest in development of small molecules targeting N-cadherins and designing of therapeutic agents to promote cell survival and axonal regeneration as well as inhibit cadherin mediated …
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Gene therapy for axon regeneration
… factors that contribute to the failure of axon regeneration in the CNS. Generally speaking, the problem of axon regeneration can be subdivided in at least two aspects: 1) the growth-repulsive environment surrounding the injured axon and 2) the low intrinsic regeneration potential of adult CNS …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… which develops within the CNS prevents regeneration. Current therapeutic strategies for traumatic CNS injury aim at patient stabilization and symptoms management, however without promoting neural tissue regeneration. Ongoing studies focus on the development of both acellular and …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… as part of the glial scar and restrict axonal regeneration. The role of injury-induced CSPG deposition on OPCs and remyelination is far less understood. In this thesis, I characterized a potent inhibitory phenotype of murine OPC adhesion and process outgrowth cultured on CSPGs in vitro. …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… injuries is hindered by a lack of spontaneous regeneration. In injuries such as stroke and traumatic brain injury, loss of viable tissue can lead to cavitation as necrotic debris is cleared. Using a rat model of penetrating brain injury, this thesis investigated the use of collagen biomaterials …
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Mitochondrial response to axonal injury
The failure of axonal regeneration is due to myriad reasons both cell intrinsic and extrinsic. In this thesis, I sought to investigate an intrinsic reason for regeneration failure in the CNS. Specifically, I investigated the role of axonal mitochondria in the axonal response to injury. A viral …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… signaling mechanisms may be important for axonal regeneration following spinal cord injury in the lamprey.
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… site in response to the insult. CSPGs inhibit axonal growth and regeneration, an action mediated by their sulfated glycosaminoglycan (GAG) chains, especially those with 4-sulfated (4S) sugars. Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without …
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The extraction of type 1 collagen and the fabrication of multi-filament embedded hydrogels for guided nerve regeneration
… some success in pre-clinical studies to induce axonal generation, but the reconnection of axons over large distances remains the greatest challenge. Since the development of nerve conduit to facilitate general axonal regeneration, the primary focus has changed to directing the regeneration of …
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hepatocyte growth factor inhibits glial scar formation and
… suppression of CSPGs production may support axonal regeneration following spinal cord injury. Hepatocyte growth factor (HGF), which was originally identified as a mitogen for hepatocytes, has been shown to strongly suppress fibrosis of internal organs such as liver and kidney. However, its …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
Traumatic axonal injury (TAI) is a consistent feature of (TBI) and is responsible for much of its associated morbidity. TAI is now recognized to result from progressive/secondary axonal injury, though much remains unknown in regards to the pathobiology and the long-term consequences of axonal …
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Characterisation of the pro-regenerative extracellular matrix in the zebrafish spinal cord
… (ECM) plays a fundamental role in the repair and regeneration of wounds to tissues throughout the body, including spinal cord injuries (SCIs). In this thesis I present a functional study of the effects of core ECM components on neuronal and glial cell behaviour in two models of SCI: the …
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Inflammasome mediated response to biomaterials implanted in the peripheral nervous system
… able to reduce FBR, without affecting neuronal regeneration. Using RNA sequencing, I have determined the differential expression of genes (between day 1 and day 28 post intervention) between a normal mouse sciatic nerve (control), a crushed one (peripheral nerve injury PNI model) and one with a …
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Cell-mediated contraction & induced regeneration of the injured peripheral nerve
… mm in humans. Observations of successful induced regeneration in adults coincide with reduced MFB formation, yet the direct effect of the MFB capsule on nerve regeneration is unknown. According to the pressure cuff theory, a transected peripheral nerve could heal by regeneration, rather than …
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Enhancing spinal cord repair with connexin43 antisense oligodeoxynucleotides
… axon outgrowth from damaged spinal cord but such regeneration is limited by new scarring resulting from the intervention itself. We have investigated the effect of Cx43 downregulation in preventing the onset of secondary injury spread and enhancing these spinal cord injury repair strategies by …
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