Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"axonal regeneration"”.
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Promoting bridging axonal regeneration after spinal cord injury
… the extent to which OECs promote long distance axonal regeneration when transplanted into spinal cord lesions. In the first chapter of Results (chapter 3) we aimed to determine the potential of OEC transplantation in promoting axonal regeneration beyond the injury. This was investigated by …
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Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
… higher vertebrates, the lamprey displays robust axonal regeneration in the central nervous system following neural injuries. For example, following spinal cord transections, the descending axons of brain neurons regenerate and reconnect with spinal targets so that locomotor behavior recovers in a …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… evaluated the potential impact of CXB-NE on neuroregeneration. In CCI, the injury and inflammation damages nerves, leading to axon degeneration distal from the site of injury. While peripheral nerves can regenerate axons, if axonal degeneration continues to occur due to inflammation, then axonal …
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Zelluläre inflammatorische Reaktion und Keratan-Sulphat-Proteoglycan-Expression nach experimentellen Kompressionsverletzungen des Rückenmarks adulter Ratten
… cord injury of adult mammals there is only poor axonal regeneration. Animal experiments showed that there are neuronal and non-neuronal reasons for the limited axonal regeneration. In the last years, the role of the restricted inflammatory response, the deposition of putatively inhibitory …
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An investigation into the characteristics and potential therapeutic application of human neural progenitor cell-derived astrocytes in experimental spinal cord injury
… of neurons, astrocytes and oligodendrocytes, axonal injury, demyelination, excitotoxicity, ischemia, oxidative damage, and inflammation. The lack of axonal regeneration is not primarily due to an inherent lack of capacity for axonal growth potential, but rather to the overall balance of …
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Thick Conducting Polymer Coatings for Safe Electric Field Delivery to the Spinal Cord
… has emerged as a promising approach to promote axonal regeneration after SCI, yet clinical translation has been constrained by the electrochemical and mechanical limitations of conventional metal electrodes. This thesis addresses these challenges by establishing a quantitative and operational …
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Tissue engineering with glial cells and a novel biodegradable matrix to promote functional repair following experimental spinal cord injuries
… more has been gained showing the potential for axonal regeneration within the nervous system of both experimental animals and humans. While most of the regenerative capacity has been identified in the peripheral nervous system (PNS), it could also be demonstrated that axonal regeneration and …
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Investigation of minimum fragment requirement for mimicking n-cadherin mediated adhesion
… that N-cadherins can promote neuronal growth and axonal regeneration in vitro. Moreover, there is a growing interest in development of small molecules targeting N-cadherins and designing of therapeutic agents to promote cell survival and axonal regeneration as well as inhibit cadherin mediated …
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Gene therapy for axon regeneration
… factors that contribute to the failure of axon regeneration in the CNS. Generally speaking, the problem of axon regeneration can be subdivided in at least two aspects: 1) the growth-repulsive environment surrounding the injured axon and 2) the low intrinsic regeneration potential of adult CNS …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… which develops within the CNS prevents regeneration. Current therapeutic strategies for traumatic CNS injury aim at patient stabilization and symptoms management, however without promoting neural tissue regeneration. Ongoing studies focus on the development of both acellular and …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… as part of the glial scar and restrict axonal regeneration. The role of injury-induced CSPG deposition on OPCs and remyelination is far less understood. In this thesis, I characterized a potent inhibitory phenotype of murine OPC adhesion and process outgrowth cultured on CSPGs in vitro. …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… injuries is hindered by a lack of spontaneous regeneration. In injuries such as stroke and traumatic brain injury, loss of viable tissue can lead to cavitation as necrotic debris is cleared. Using a rat model of penetrating brain injury, this thesis investigated the use of collagen biomaterials …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… signaling mechanisms may be important for axonal regeneration following spinal cord injury in the lamprey.
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Mitochondrial response to axonal injury
The failure of axonal regeneration is due to myriad reasons both cell intrinsic and extrinsic. In this thesis, I sought to investigate an intrinsic reason for regeneration failure in the CNS. Specifically, I investigated the role of axonal mitochondria in the axonal response to injury. A viral …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… site in response to the insult. CSPGs inhibit axonal growth and regeneration, an action mediated by their sulfated glycosaminoglycan (GAG) chains, especially those with 4-sulfated (4S) sugars. Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without …
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The extraction of type 1 collagen and the fabrication of multi-filament embedded hydrogels for guided nerve regeneration
… some success in pre-clinical studies to induce axonal generation, but the reconnection of axons over large distances remains the greatest challenge. Since the development of nerve conduit to facilitate general axonal regeneration, the primary focus has changed to directing the regeneration of …
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hepatocyte growth factor inhibits glial scar formation and
… suppression of CSPGs production may support axonal regeneration following spinal cord injury. Hepatocyte growth factor (HGF), which was originally identified as a mitogen for hepatocytes, has been shown to strongly suppress fibrosis of internal organs such as liver and kidney. However, its …
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The characterization of the anterograde and retrograde consequences of traumatic axonal injury in a mouse model of diffuse brain injury
Traumatic axonal injury (TAI) is a consistent feature of (TBI) and is responsible for much of its associated morbidity. TAI is now recognized to result from progressive/secondary axonal injury, though much remains unknown in regards to the pathobiology and the long-term consequences of axonal …
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