Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"axonal loss"”.
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… autoreactive T cells that mediate demyelination, axonal loss, and neuroinflammation. Among the pathogenic T helper subsets, Th17 cells are pivotal in MS progression, producing high levels of proinflammatory cytokines such as IL-17. While Interferon-gamma (IFN-γ) is traditionally seen as …
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Longitudinal Evaluation of Retinal Capillaries in Experimental Glaucoma
… cause of irreversible blindness worldwide. The loss of radial peripapillary capillaries (RPCs) has been hypothesized to play a role in retinal ganglion cell axon degeneration in glaucoma. Previous histological work has shown that structural alterations and losses of RPCs are associated with …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… caspase-6 is specifically activated within the axonal compartment. The temporal and spatial pattern of activation demonstrates that neuronal caspase-9 activity induces caspase-6 activation, which mediates axonal loss in the early stages of stroke (+/- 24 hours). We developed a novel inhibitor …
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SELECTIVE CB2 RECEPTOR ACTIVATION AMELIORATES INFLAMMATION IN CENTRAL NERVOUS SYSTEM BY REDUCING TH17 CELL DIFFERENTIATION AND IMMUNE CELL ACCUMULATION.
… with long term reduction in demyelination and axonal loss. We also established that Gp1a affected EAE through at least two different mechanisms, i.e. an early effect on Th1/Th17 differentiation in peripheral immune organs, and a later effect on the accumulation of pathogenic immune cells in the …
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Neurodegeneration and behavior in rodents treated with chronic methamphetamine
… administration. While it was shown that SNc cell loss does not occur after 14 days of this meth treatment regimen, it is unclear whether axon loss begins at this point and whether axonal loss precedes somatic loss in these regions. Additionally, while chronic meth use in humans is correlated with …
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Multiple Sclerosis: Studies of the Interferon system and search for infectious agents
… inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. Interferons (IFNs) are naturally occurring proteins known to have antiviral, antiproliferative and …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
Axonal degeneration is the major cause of disability in progressive multiple sclerosis (MS). It has been shown that in MS and relevant disease models, demyelinated axons harbor an increased number of mitochondria, which is reflected in bigger stationary sites of mitochondria, increased …
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Bioenergetic neuroprotection in experimental glaucoma
… of the number of surviving RGCs and axonal injury, respectively. The combined results clearly demonstrate RGC preservation, decreased axonal loss and degeneration, and attenuated microglial proliferation and phagocytic activity in the retinal nerve fibre layer and optic nerves of …
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Axon-glia interactions during central nervous system myelination
… oligodendrocyte-lineage cells following this axonal loss- or gain-of-function. In kinesin-binding protein (kbp) mutants, reticulospinal hindbrain neurons start axonogenesis but axons fail to grow along the entire spinal cord as in wildtype, providing an axon-deficient posterior spinal cord and …
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Alternative Neuropsychological and Magnetic Resonance Imaging Measures in Multiple Sclerosis: Exploring the relation between brain lesion measured by diffusion tensor magnetic resonance imaging and interhemispheric communication and processing speed in multiple sclerosis
… preferentially along the direction of the axonal fibers. Intact myelin sheets are effective barriers for the water. Demyelination, an important pathological aspect of MS, leads to decreased delineation of the tracts along which the water spreads. This results in changed diffusion derived …
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Structural organization in 9-year-old HIV-infected children and HIV-exposed children
… white matter injury associated with myelin loss and axonal degradation. We hypothesize continued diffuse white matter abnormalities in these regions, pointing to chronic damage from at age 5. Tractography quantifies tract properties within the context of gray matter regions, giving …
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Commonalities between SMA and ALS: investigation of ribosome heterogeneity and translational defects
… are commonly observed in both diseases and loss of SMN and dysregulation of TDP43 and MATR3 are associated with translation defects of specific mRNAs. Therefore, exploration of a direct involvement of these proteins in translation may reveal a still uncharacterized level of heterogeneity …