Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"axon transport"”.
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Lis1 and Ndel1 Regulate Dynein-Mediated Organelle Transport In Adult Neurons
… motor is best known for its role in retrograde axonal transport (3), but also clearly functions with Lis1 and Ndel1 to control distinct developmental processes. If embryonic defects are solely responsible for the symptoms associated with neurological disorders such as lissencephaly then …
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
… essential growth-molecules become excluded from axons with maturation. In this thesis, two strategies were employed in order to improve axon regeneration: 1) restoring the axonal transport of growth-molecules in mature axons via manipulation of transport machinery; 2) reverting mature neurons to …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… components: dendrites, a cell body, and an axon. Due to their distinct functions, precise protein localization within neurons is essential for maintaining neuronal homeostasis. Certain proteins exhibit notable enrichment in axon terminals, where they exert pivotal influences on neuronal …
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Effect of nitric oxide and inflammatory mediators on axonal transport
… der Aktivierung von Microgliazellen auf den Transport von Organellen, Vorläufervesikel und Mitochondrien in Axonen untersucht. Mikrogliazellen sind mitverantwortlich für die Immunreaktionen im Gehirn und setzen dabei Stickstoffmonooxid und entzündliche Mediatoren frei Durch Kombination von …