Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"axon terminals"”.
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
… glutamate transporter associated with excitatory terminals, particularly in CA3 pyramidal neuron axon terminals within CA3 and CA1 as well as in cortical layer V pyramidal neuron axon terminals within striatum. The specific functions of GLT-1 in axon terminals in regulating glutamate homeostasis …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… components: dendrites, a cell body, and an axon. Due to their distinct functions, precise protein localization within neurons is essential for maintaining neuronal homeostasis. Certain proteins exhibit notable enrichment in axon terminals, where they exert pivotal influences on neuronal …
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Spinal interneurons in sensorimotor integration
… pathways; (3) to investigate cholinergic terminals in the ventral horn of adult rat and cat. To realize the first aim, the B-subunit of cholera toxin (CTb) was injected into the motor nuclei at the L1 or L3 segmental level to retrogradely label propriospinal interneurons in the L5 segment …
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Development of neuronal connectivity in the central nervous system of Drosophila melanogaster
… partners. The mechanisms by which presynaptic axon terminals and postsynaptic dendrites recognize each other and establish the correct number of connections with the appropriate strength are poorly understood. Sperry’s chemoaffinity hypothesis proposes that pre- and postsynaptic partners …
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Cross-Modal Projections from Auditory to Visual Cortices in the Ferret
… ferrets. After transport and processing, labeled axon terminals were found not in primary visual cortex, but in area 19, or V3. Injection of tracer into V3 of 3 additional ferrets produced retrogradely labeled neurons not in the core region of auditory cortex, but along its posterior borders. …
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Behavioural microanalysis of dopamine autoreceptor function
… DA autoreceptors on the sona/dendrites and axon terminals of DA neurons. Low doses of apomorphine reduced food Intake, in a microstructural analysis paradigm, by reducing both the time spent feeding and the rate of food ingestion. The reduction of eating time was shown to result from the …
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Passive Electrical Properties of Horizontal Cells in the Retina of the Turtle, Pseudemys Scripta Elegans
… measurable value); these probably represented H1 axon terminals. The relatively small values for L and large values for (rho) observed in all luminosity-type cells mean that a post-synaptic signal, introduced at the distal end of a dendrite, can spread passively along the dendrite, cross the soma, …
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Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
… shown to strongly promote neuronal survival and axon regeneration after central nervous system (CNS) injury. This is in part due to increased levels of integrins in the distal axon, but this mechanism does not fully account for its beneficial effects. We have investigated protrudin's effects on …
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Multi-Scale Modeling for Analysis and Design of Transcranial Electric and Magnetic Brain Stimulation
… These models included 3D reconstructed axonal and dendritic arbors as well as multiple excitatory and inhibitory cell types with validated electrophysiological behavior. Axon terminals were the lowest threshold elements for stimulation, and their dependence on threshold and polarization …
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Neuromuscular Synaptic Proteins In Development And Regeneration
… clusters acetylcholine receptors beneath motor axon terminals, yet in vivo role of this pathway in peripheral nerve regeneration has not been examined. To determine whether this pathway is employed during regeneration, I used a previously established assay to transect spinal motor nerves and …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS
… Immunolocalization was measured throughout the axon and axon terminals of motorneurons. We found no significant difference in mitochondrial populations within the pre-or post-synapse of control and msBDNF deficient animals. Results indicate that co-labeling mitochondria in a sciatic nerve …
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The Roles of Wnt5 and the Drl Receptor in the Development of the Drosophila Olfactory System
… the same odorant receptors converge their axons precisely onto a specific set of projection neuron dendrites, forming glomeruli in stereotypic positions of the antennal lobe. Although many studies have revealed the crucial role of projection neurons in the spatial patterning of glomeruli, …
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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX
… immunoreactivity of 5-HT at the thalamocortical axon terminals (TCAs) in the region of the somatosensory cortical barrel field. In the forebrain, Pb appears to decrease 5-HT levels in general. This differs from its effect in the brainstem where Pb appears to specifically target central auditory …
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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX
… immunoreactivity of 5-HT at the thalamocortical axon terminals (TCAs) in the region of the somatosensory cortical barrel field. In the forebrain, Pb appears to decrease 5-HT levels in general. This differs from its effect in the brainstem where Pb appears to specifically target central auditory …
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Behaviorally-Induced Structural Remodeling of the Hippocampus
… of metal such as zinc in newly formed axon terminals. A repeated measures ANOVA was conducted to determine if there was a significant difference between radiation and water maze performance. There were no other significant differences in spatial or probe performance. Hippocampal tissue …
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Optimization-Based Methods for Reconstruction and Structural Quantification of Neurons and Glia from Microscopic Images
… structures formed by dendritic spines, axon terminals, and astrocyte processes, which are crucial for understanding and predicting the functions of neural circuits. However, most methods for segmenting dendritic spines from electron microscopy images focus solely on surface information …
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Mechanisms of pain processing: spinal protein translation in the rat
… messenger ribonucleic acid (mRNA) in dendrites, axons, axon terminals as well as cell bodies, is essential for long-term synaptic plasticity and may therefore be important in pain processing. The protein kinase mammalian target of rapamycin (mTOR) is a key regulator of protein translation and can …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
… remaining dopaminergic neurons, serotonergic terminals, and striatal intemeurons.</p> <p>Studies have shown that serotonin (5-HT) neurons are capable of DA synthesis following exogenous L-dopa administration. In addition, striatal hyperinnervation by serotonergic dorsal raphe nucleus (DRN) …
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In vivo and in vitro approaches to characterising axon growth and metabolic alterations in Parkinson’s disease
… before dying. The preposition that dopaminergic axons degenerate initially and predominantly in PD offers new critical opportunities for the development of neuroprotective and restorative therapies. However, we know little about how dopaminergic neurons innervate their target areas. Because of …
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The midbrain reticular formation in flexible visual decision-making
… that context-coding neurons and cortical axon terminals both contain non-uniform distribution patterns and are spatially aligned (Chapter 5). Altogether, our results establish MRF as a key node in the circuitry underlying flexible visual decisions and provide fundamental insights into how …
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