Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"axon pathfinding"”.
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… reveal a specific programme for zebrafish motor axon pathfinding I established a method to selectively block motor axon pathfinding by interfering with LIM domain transcription factor signaling. LIM homeodomain proteins (LIM-HDs) are an important class of transcriptional regulators and involved …
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The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… EphB1 mediated signaling in retinal and callosal axons while attempting to reach their targets. EphB receptor tyrosine kinases direct axonal pathfinding through interactions with ephrin-B proteins following axon-cell contact. Since EphB:ephrin-B binding leads to bidirectional signals, the …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… in altered GMC4-2a cell fate and faulty RP2 axon pathfinding. In addition to the RP2 motoneuron, hkb also regulates axon pathfinding of two other motoneurons deriving from NB4-2.
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
… in altered GMC4-2a cell fate and faulty RP2 axon pathfinding. In addition to the RP2 motoneuron, hkb also regulates axon pathfinding of two other motoneurons deriving from NB4-2.
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
… signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral nervous system. Owing to their role in axon pathfinding during development it is …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… system development, growing neurons extend axons over long distances to defined targets. Despite decades of research dedicated to understanding how neurons are guided along the correct pathways, we still do not fully understand the mechanisms underlying axon pathfinding. In this project, I …
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In vivo and in vitro guidance of developing neurons by mechanical cues
During nervous system development, growing axons navigate towards their targets using signals from their environment. These signals may be biochemical or mechanical in nature; however, the role of mechanical cues in axon pathfinding in vivo, and the spatiotemporal dynamics of embryonic brain …
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The mechanical regulation of Semaphorin3A signalling in the developing Xenopus laevis brain
… the functioning of the mature brain. Failure of axons to connect to their correct downstream targets is linked to a host of neurodevelopmental disorders. Axons extending through the developing brain interpret gradients of both chemical and mechanical cues for navigation. In this thesis, I …
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Role of Laminin gamma 1 in Cortical Development
… layer was affected in the mutants. Furthermore, axon pathfinding was impaired with developing axons projecting along the abnormally structured cortical plate. Laminin γ1 also plays a role at the cellular level, as disturbances in normal neuronal morphology were observed in mutant animals, but …
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Analysis of Postsynaptic Morphology During Neuromuscular Synaptogenesis in Drosophila Melanogaster
… neuromuscular system during the period of axon pathfinding and synaptic targeting. Embryonic Drosophila muscle cells extend numerous actin-based microprocesses (myopodia) during these stages of development. While the initial extension of myopodia appears random, their spatial distribution …
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Repulsive axonal pathfinding requires the Ena/VASP family of actin regulatory proteins in vertebrates
… the highly motile "growth cone" at the tip of an axon must sense extracellular embryonic cues and respond through a number of intracellular interactions leading ultimately to coordinated changes in cytoskeletal morphology and modulation of the axonal path. Here I describe axon pathfinding defects …
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Novel EphB Receptor Forward Signaling Pathways in the Development of Major White Matter Tracts of the Mammalian Brain
… and subsequent developmental steps, including axon guidance, establish the functional circuitry between young neurons. Axon guidance is characterized by the growth of axonal processes that sprout from neuronal cell bodies and navigate within the developing brain to reach target synaptic zones. …
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The Reinnervation of Sensory Hair Cells Following Lesion of the Lateral Line Cranial Nerve
… accessible model for studying the mechanisms of axon pathfinding and target selection. The posterior portion of the lateral line is composed of superficial sensory hair cells, genetically and functionally similar to hair cells of the inner ear, clustered into organs called neuromasts that are …
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Deep vertebrate roots for mammalian krab zinc-finger transcription factors
… best known for their roles in neurogenesis and axon pathfinding, but also recently shown to play critical roles in placental development. Since ZNF777 is also expressed in embryonic brain, we sought to further investigate the functional role of this ancient gene in neuron development. In chapter …
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
… in many developmental processes including axon guidance. In the nervous system, concentration gradients of Ephs and ephrins are crucial in guiding retinal ganglion cell (RGC) axons from the retina to the right targets in the visual area of the brain, the optic tectum. However, despite …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
During brain development, neurons extend axons to distant regions. These axons are guided towards their correct targets by various chemo-mechanical signals. Major chemical signals include semaphorins, slits, netrins and ephrins/Eph, whereas mechanical signals include tissue stiffness, viscosity and …
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The role of tissue viscoelasticity in axon guidance during Xenopus brain development
During nervous system development, axon bundles grow over large distances along well-defined pathways, guided by gradients of chemical cues in their environment. In addition, axons mechanically interact with their environment and respond to stiffness gradients they may encounter in the developing …