Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"axon degeneration"”.
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …
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Retrograde Activation of a Somatic Transcriptional Program Regulates Distal Axon Degeneration
… of the peripheral nervous system, sensory axons extend to the periphery in excess where they compete for limiting target-derived neurotrophic support. Local neurotrophin insufficiency triggers axon degeneration, resulting in the pruning of over half of all sensory axons during development. …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
After peripheral nervous system injury, axons degenerate through a process termed Wallerian degeneration and Schwann cells transform into a repair phenotype. Axon degeneration is regulated by a signalling pathway controlled by the pro-degenerative axon death molecule sterile-alpha and …
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Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
… bleibende Sehbehinderung verursacht durch eine Degeneration von Sehnerv-Axonen. In Vorarbeiten konnten wir zeigen, dass die experimentelle autoimmune Enzephalomyelitis (EAE), ausgelöst durch Immunisierung mit Myelin-Oligodendrozyten Glykoprotein (MOG), in braunen Norweger-(BN)-Ratten in 90 % der …
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Chronic activation and downstream mechanisms of programmed axon death
Axon loss is a characteristic feature shared among various neurodegenerative disorders, regardless of their distinct primary causes. Programmed axon death is a conserved, well-characterised pathway of axon degeneration activated by physical injury and in disease states. The two main regulators of …
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The Apoptotic and Wallerian Degeneration Pathways Regulate Disease Onset and Progression in the SOD-1G93A Transgenic Mouse Model of ALS
… by progressive muscle denervation, motor axon degeneration and the death of motor neurons. The molecular mechanisms that mediate axon degeneration in ALS remain unknown, but motor neuron cell body death occurs through apoptosis. Genetic deletion of the pro-apoptotic gene Bax delays muscle …
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Mutational and Structural Investigation of SARM1, a Protein that Mediates Axon Loss
… NADase that executes the programmed axon degeneration pathway after nerve injury and in diseases including polyneuropathies. The ARM domain of SARM1 plays a crucial role in regulating its NADase activity. By attenuating this activity, axon degeneration is delayed, making SARM1 an …
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Biochemical and Cellular Characterization of NMN Adenylyltransferase 2: A Brain Specific Isoform of an Essential NAD Synthesizing Enzyme
… overexpression in neurons slows the rate of axon degeneration. This phenotype requires Nmnat activity and is caspase-independent suggesting that neuronal NAD metabolism regulates a novel program of self-destruction in axons. Nmnat2 is detected exclusively in the brain, unlike Nmnat1 and …
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Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
Programmed axon death is a well-characterized, preventable pathway leading to axon degeneration. Programmed axon death is regulated by SARM1, a pro-degenerative, multi- functional enzyme that consumes NAD and NADP, with dramatic consequences for neuron energy metabolism. Accumulating evidence in …
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Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses
… alignment with an intact epineurium, loss of axons (axon drop out), axon degeneration, fibrosis and inflammation in alcohol- and formaldehyde-injected nerves compared to control nerves. Formaldehyde injection induced greater fibrosis and inflammation than alcohol.Conclusions and Clinical …
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Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival
… that when myelin contacts aberrantly growing axons, it activates on those axons the p75 neurotrophin receptor (p75NTR), which in turn causes the local degeneration of those axons. I further identified the signal transduction pathway required for axon degeneration consisting of p75NTR and …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
… and inflammation damages nerves, leading to axon degeneration distal from the site of injury. While peripheral nerves can regenerate axons, if axonal degeneration continues to occur due to inflammation, then axonal regeneration cannot proceed. Ultimately, axonal regeneration can be an …
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Cellular Interactions During Motor Nerve Regeneration
… nerves can regenerate, enabling severed axons to reconnect with their original synaptic targets. The interactions between injured nerves with cells in their environment, as well as the functional significance of these interactions, have not been determined in vivo and in real time. Here …
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Longitudinal Evaluation of Retinal Capillaries in Experimental Glaucoma
… to play a role in retinal ganglion cell axon degeneration in glaucoma. Previous histological work has shown that structural alterations and losses of RPCs are associated with glaucomatous pathology. However, the lack of longitudinal in vivo data characterizing RPC alterations in …
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A DLK And JNK Dependent Axon Self-Destruction Program Promotes Wallerian Degeneration
Axon loss is a debilitating consequence of a wide range of neurological conditions. As axons degenerate, they go through a stereotyped sequence of morphological changes termed Wallerian degeneration. It has long been hypothesized that there is an active axonal breakdown program, conceptually …
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
… Additionally, ASICs mediate neuron death and axon degeneration during pathological conditions such as ischemic stroke, inflammation, and traumatic injury. My thesis work began focused on ASICs in the peripheral nervous system. In rodent sensory neurons ASICs contribute to sensory transduction …
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Mitofusin 2 Regulated Transport of Mitochondria is Necessary for Axonal Integrity
The ubiquitous finding of axonal degeneration in a number of the most prevalent neuropathologies marks the importance of understanding axonal biology and the axonal self-destruct mechanism. Though our understanding of axonal degeneration remains largely incomplete, several down-steam steps of the …