Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"axon branching"”.
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Eph-Ephrin Signaling and the Role of EFN-4 in Caenorhabditis Elegans Nervous Systems Development
… aspects of nervous system development including axon outgrowth, synaptic plasticity, and the formation of topographic maps in the visual system. The <em>Caenorhabditis elegans </em>ephrin-A, <em>efn-4</em>, has a defined role in hypodermal patterning but its role in nervous system development is …
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Molecular genetics of the imprinted gene - SPROUTY3 (SPRY3)
… proteins are key regulators of cell growth and branching morphogenesis during development. Human SPRY3 which maps to the pseudoautosomal region 2, undergoes random X-inactivation in females and preferential Y-inactivation in males, behaving as though genetically X-linked. Spry3 is widely …
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The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
… development cortical neurons extend a primary axon and multiple collateral branches to connect to numerous synaptic targets. While many guidance cues and their receptors have well-characterized roles in cortical axon guidance, the pathways that link these signals to cytoskeletal remodeling …
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Dissecting the Development and Function of C. elegans Glia with Mutations of the mls-2 and vab-3 Genes
… roles for CEPsh glia in dendrite extension and axon branching and guidance, and show that these latter functions are mediated, at least in part, by the UNC-6/Netrin protein. During the course of this study, I also confirmed that C. elegans CEPsh glia are not required for neuronal survival. …
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Regulation by ERK1/2 of Novel Substrates, Kinesins KIF2A and KIF2C
… as KIF2A-/- neurons exhibit abnormal axon branching. Though protein kinases are known to regulate the mitotic function of KIF2A, how KIF2A is regulated in interphase cells has not been studied. In a yeast-two hybrid screen, designed to preferentially uncover interactors of the active …
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EphB: Ephrin-B Bidirectional Signaling in Retinocollicular Mapping
Retinal ganglion cell axon exit into the optic disc and formation of the optic nerve and termination in the superior colliculus is critical for integrating both the visual field and head orientation to mediate appropriate eye movement. Expression of EphB receptor tyrosine kinases and ephrin-B …
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Microtubule Dynamics in Neuronal Morphogenesis
… dynamics include failure to specify the axon and dendrite of neurons, and can lead to neurological defects due to failed neuronal migration. Inhibited microtubule dynamics in neurons also lead to morphological defects and dampened synaptic plasticity. This review discusses the current …
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The role of the RNA-binding protein FUS in axonal organisation and disease
The role of the RNA-binding protein FUS in axonal organisation and disease In this thesis, I discuss the role of the RNA-binding protein Fused in sarcoma (FUS) in axonal organisation and disease. FUS aggregates in forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and …