Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 379 for “"axon"”.
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Gene therapy for axon regeneration
… many factors that contribute to the failure of axon regeneration in the CNS. Generally speaking, the problem of axon regeneration can be subdivided in at least two aspects: 1) the growth-repulsive environment surrounding the injured axon and 2) the low intrinsic regeneration potential of adult …
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Deciphering the biology of axon stretch-growth
… occurs primarily during embryogenesis. Early axons continue to grow from the end distal to the soma, seeking targets on which to synapse. It is believed that once the axons synapse, stretch-growth takes over and is responsible for the great lengths achieved by nerves of the central and …
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Axon Guidance In The Mouse Olfactory System
… drive microarray based method to identify novel axon guidance molecules expressed by the target of this process, the olfactory bulb. This method is designed to identify genes that are differentially expressed within the developing olfactory bulb during the developmental stages when olfactory …
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Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in Netrin-Dcc/Frazzled Axon Attraction
… the stepwise process of neural specification, axon guidance and synaptogenesis. Axon guidance, the process by which neurons extend axons to their final targets, relies on the presence of extracellular cues, and their respective guidance receptors. Intracellular molecules that transduce these …
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Design of three-dimensional axon stretch growth device
… (SCI) causes destruction and degeneration of axons in the white matter of the spinal cord, resulting in functional loss and paralysis. A successful treatment of SCI requires axons to regenerate across damaged regions. Current studies focus on identifying mechanisms to promote axon regeneration …
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Mechanisms of plasticity at the axon initial segment
The axon initial segment (AIS) is a highly specialised neuronal subcompartment located within the proximal axon that has a crucial role in the generation of action potentials. Recent research has shown that this structure is plastic and can undergo changes in its length or location over a period of …
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Axon-glia interactions during central nervous system myelination
… speeds up action potential propagation along axons, which is fundamental for the correct function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control myelination, as …
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Compartmentalization and axon guidance in the Drosophila brain
… cell mispositioning and aberrant photoreceptor axon targeting. Thus, Slit and Robo proteins are required to restrict movement of cells across the lamina/lobula boundary. Additionally, I have characterized Ptpmeg, a highly conserved protein tyrosine phosphatase (PTP). In addition to the …
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Using Lipid Bilayers in an Artificial Axon System
… component failure. In this thesis, an artificial axon system using droplet on hydrogel bilayers (DHBs) in conjunction with alamethicin channels was developed to show properties of action potential signal propagation that occur in myelinated nerve cells. The research demonstrates that the …
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Axon Development and Synapse Formation in Olfactory Sensory Neurons
… sensory neurons (OSNs) that project their axons to the olfactory bulb (OB) where they establish connections to the central nervous system. The olfactory epithelium is therefore an attractive model for the study of axonal growth and synapse formation. The present set of studies attempts to …
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Chronic activation and downstream mechanisms of programmed axon death
Axon loss is a characteristic feature shared among various neurodegenerative disorders, regardless of their distinct primary causes. Programmed axon death is a conserved, well-characterised pathway of axon degeneration activated by physical injury and in disease states. The two main regulators of …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic obstacles. Following injury, chondroitin sulfate proteoglycans (CSPGs) accumulate within the glial scar that forms at the lesion site in response to the insult. CSPGs inhibit …
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …
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Repulsive cues and signalling cascades of the axon growth cone
… of action of repellent cues for growing axons. In particular I try to resolve the controversy in the literature regarding the need for protein synthesis in the growth cone in response to external guidance cues. My results resolve the conflicting data in the literature on Semaphorin-3A …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… neuraxis to undergo neuronal replacement and axon targeting following injury, has led to scrutiny concerning the molecular and physical determinants of this growth capacity. This is because injury to the central nervous system, in contrast, leads to permanent disconnection of neurons with …
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Retrograde Activation of a Somatic Transcriptional Program Regulates Distal Axon Degeneration
… of the peripheral nervous system, sensory axons extend to the periphery in excess where they compete for limiting target-derived neurotrophic support. Local neurotrophin insufficiency triggers axon degeneration, resulting in the pruning of over half of all sensory axons during development. …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… mutant esrom shows that it is required for axon fasciculation, targeting, branching and skin pigmentation. In the visual system esrom is necessary for the formation of topographic map along the A-P and D-V axis, correct innervation of the pretectal targets and axon bundling in the optic …
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Analysis of Growth Cone Signaling During Axon Development in Drosophila Melanogaster
… that Cdc42 controls filopodial activity in axonal growth cones independently of its effects on their guidance. Furthermore, my studies begin to suggest that actin reorganization alone cannot mediate proper axon outgrowth or guidance.
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