Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"auxiliary subunits"”.
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Understanding Voltage -Gated Ion Channels via Molecular Archeology
… voltage. These channels are composed of multiple subunits. There are 11 families of auxiliary subunits included in this study. Each family of channels and auxiliary subunits was tabulated and analyzed phylogenetically. A phylogenetic tree is derived from sequence alignment of each family. …
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The voltage gated calcium channel β2 protein is required in the heart for control of cell proliferation and heart tube integrity
… entry into cardiomyocytes. CACNB2 (β2) LTCC auxiliary subunits traffic the pore-forming CACNA subunit to the membrane and modulate channel kinetics. β2 is a Membrane Associated Guanylate Kinase (MAGUK) protein. A major role of MAGUK proteins is to scaffold cellular junctions and multi-protein …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
… contain a pore-forming alpha1 subunit and auxiliary alpha2delta, beta and gamma subunits. Of the three auxiliary subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium currents regulate rhythmic …
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AMPA receptor diversity and dynamics during excitatory synaptic transmission
… as well as their association with various auxiliary subunits. Using results from a combination of electrophysiology and light microscopy, this thesis probes the synaptic trafficking and short-term and long-term plasticity behaviour of GluA1-4. The sequence diverse N-terminal domains (NTD) …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… post-translational modifications of Navs and/or auxiliary subunits as well as protein-protein interactions as Nav-trafficking mechanisms. Here, I tested if post-translational modifications of a novel Nav1.7-interacting protein, the axonal collapsin response mediator protein 2 (CRMP2) by small …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… kinetics of the channels and their modulation by auxiliary subunits. Cell biological questions such as trafficking and clustering of the channels at the presynaptic site, however, have remained largely unanswered, partly due to a lack of an in vivo assay system to monitor calcium channel …
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MECHANISMS OF CHROMATIN REMODELING BY ISWI FAMILY OF REMODELERS: A FUNCTIONAL AND STRUCTURAL INSIGHT INTO THE ROLE OF THE Itc1 SUBUNIT OF ISW2 REMODELING COMPLEX
… complexes have a relatively small number of subunits (2-4) as compared to other classes of remodelers such as SWI/SNF, RSC and INO80/SWR-C. The accessory subunits of some of the ISWI remodelers from yeast have been shown to contact extensively extranucleosomal or linker DNA and appear to be …
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Structural and Functional Effect of Phosphorylation On Ampa Receptors
<h1>Structural and Functional Effect of Phosphorylation on AMPA Receptors</h1> <p>Cailtin Edmunds show you, BA</p> <p>Advisory Professor: Vasanthi Jayaraman, Ph. D.</p> <p>The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is the primary contributor to neuronal fast excitatory …