Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"autoubiquitination"”.
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Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma
… function of HDM2, as confirmed in a cell-free autoubiquitination assay. Interestingly, these results report for the first time a novel mechanism of HDM2 antagonism by MI-219 in wt-p53 lymphoma cells that stimulates HDM2 autoubiquitination. Additionally, it corresponds with biological response …
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Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI
… Analytical size-exclusion chromatography, autoubiquitination, and electron microscopy reveal consistent behavior for this triple-mutant. Future structure-based studies will help elucidate the mechanism of the unsolved mystery of RBR activation and its interaction with NEDD8ylated cullin …
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Uncovering the Complexity of RAS Signaling Networks
… predicted UBP-ZnF was examined for regulation of autoubiquitination. Together, these data point to the existence of multiple regulatory inputs that control IMP activity. Finally, we discuss the importance of establishing true binding relationships between associated proteins for the …
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Function of Znf668 In Cancer Development
… p53. By binding to MDM2, ZNF668 regulates MDM2 autoubiquitination and prevents MDM2-mediated p53 ubiquitination and degradation; ZNF668 deficiency impairs DNA damage-induced p53 stabilization. Notably, ZNF668 effectively suppresses breast cancer cell proliferation and transformation <em>in vitro …
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IAP antagonist Grim mediates cell death through divergent pathways
… caspases from IAP-binding, and to promote IAPs autoubiquitination. Herein, we demonstrate that a Drosophila IAP antagonist, Grim, induces cell death through divergent mechanisms: an IBM-dependent pathway, requiring a crosstalk with Drosophila IAP1 (DIAP1), and an IBM-independent manner, …
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Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding
… to promote PFV VLP release correlated with their autoubiquitination activity, but not with their ability to ubiquitinate a Gag substrate containing late domain-proximal lysine residues. Importantly, direct fusion of ubiquitin to the C-terminus of lysine free PFV Gag rescued budding in the absence …