Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"autotransporter"”.
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Characterisation and secretion mechanism of Bordetella pertussis autotransporter proteins
… identified as a new member of the B. pertussis autotransporter family of proteins that includes PRN, BrkA, TCF and Vag-8, largely due to its homology at the C-terminus and some other similar regions such as the RGD (integrin-binding) and SGXG (glycosaminoglycan-binding) motifs. The bap-5 gene …
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Polarity and secretion of Shigella flexneri IcsA: a classical autotransporter
The classical autotransporter IcsA is an essential virulence factor for the enteropathogen Shigella flexneri as it provides adherence properties and allows intra- and intercellular spreading in the colonic mucosa. IcsA is an outer membrane surface protein that specifically hijacks host-cell actin …
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Genetic analysis and characterisation of the BapC autotransporter of bordetella pertussis
The autotransporters are a family of extracellular proteins, found in various Gram-negative bacteria, that have many different functions but appear to have a similar mechanism of export. In B. pertussis, the virulence-regulated proteins Pertactin, BrkA, Tcf, and Vag8 have structural homology at …
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Investigating the Role of Trimeric Autotransporter Adhesins in Fusobacterium nucleatum Pathogenesis
… adhesins called Type 5c secreted trimeric autotransporter adhesins (TAAs), which are a family of proteins that are historically known for their contributions to bacterial pathogenesis. This dissertation encompasses the use of recombinant protein expression systems and newly developed gene …
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Cha-Cha-Cha: Variable Adhesive Activity of the <italic>Haemophilus</Italic> Cryptic Genospecies Trimeric Autotransporter Cha
… called Cha that shares homology with trimeric autotransporters. Trimeric autotransporters are composed of an N-terminal signal peptide, an internal passenger domain that harbors adhesive activity, and a short C-terminal membrane anchor domain and are classically characterized by …
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Characterisation of the virulence-related, outer-membrane proteins of B. pertussis
At the beginning of this study, knowledge of autotransporter proteins was in its infancy and the B. pertussis proteins pertactin, BrkA and tracheal colonisation factor (Tcf) had not been recognised as members of this family. However, the sequence similarity between these Bordetella proteins and a …
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From "wet biology" to statistical analysis of structural features with bioinformatics tools
… that a sixth—YfaL—may be an outer membrane autotransporter.
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Decoding novel virulence strategies in Fusobacterium invasion and survival
… the first insight into the roles of the type 5a autotransporters. Using a deletion library of genes encoding for the type 5a autotransporter proteins in F. nucleatum ATCC 23726, we systemically characterized altogether 12 type 5a proteins with a focus on the invasion of colorectal cancer cells. …
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Beschreibung und Charakterisierung einer neuen Pathogenitätsinsel, integriert in das selC-Gen von "Locus of enterocyte effacement"-negativen, Shiga-Toxin-produzierenden Escherichia coli
… ist charakteristisch für sogenannte Autotransporter-Proteine. Trotz der hohen Sequenzhomologie zur IgA1-Protease von Neisseria gonorrhoeae, die als Prototyp der Autotransporter-Proteine gilt, konnte für EspI keine Proteaseaktivität gegenüber IgA gezeigt werden. EspI weist auch hohe …
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Biofilm Formation by Moraxella Catarrhalis
… and Hag, which are all putative members of the autotransporter protein family. The Hag protein of strain O35E was shown to be necessary for hemagglutination, autoagglutination, and binding of human IgD. A crystal violet-based assay utilizing 24-well tissue culture plates was also used to …
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In vitro-Untersuchungen zum Sekretionsmechanismus von Pathogenitätsfaktoren mit einer N-terminalen Extension in Escherichia coli
… flexneri gehören. Hierbei handelt es sich um Autotransporter bzw. TpsA Proteine, die sich einerseits durch eine enorme Proteinlänge, andererseits durch eine stark positiv geladene und lange N-Region innerhalb der Signalsequenz, sowie durch eine N-terminale Extension, die der Signalsequenz am …
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Studies on the architecture and on transferability of pathogenicity islands of uropathogenic Escherichia coli strain 536
… a phosphoglycerate transport system, an autotransporter, as well as for hypothetical proteins. Downstream of 'pheV, the K15 capsule determinant (kpsK15) of this strain is located. Structural analysis of the 20-kb kpsK15 locus revealed a so far unknown genetic organisation indicative of …
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Laying the Genetic and Molecular Foundation for the Study of Fusobacterium Nucleatum in Relation to Human Health and Disease
Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium that is a member of the human oral microbiota. Although it is a normal resident of the mouth, it is associated with a number of human diseases including: sepsis, inflammatory bowel disease (IBD), and colorectal cancer (CRC). Despite …