Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"autotaxin"”.
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
… Data from our laboratory demonstrate that autotaxin (ATX), also referred to as phosphodiesterase Iα/autotaxin (PD-Iα/ATX), is involved in all of these processes as a multifunctional protein by regulating lysophospholipid signaling and cell-extracellular matrix interactions. Previously, our …
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The Role of Autotaxin in Cancer
Autotaxin (ATX/ENPP2) is a secreted phospholipase D enzyme that converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA is the agonist for at least six G protein coupled receptors whose activation stimulates cell proliferation, survival and migration. Overexpression of ATX and …
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Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin
… and validated the lysophospholipase D enzyme, autotaxin, a promoter of migration, invasion, and tumorigenesis, to be down regulated after silencing galectin-3. Silencing galectin-3 significantly reduced the promoter activity of autotaxin. Interestingly, we also found the transcription factor …
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The Design and Synthesis of Autotaxin Inhibitors and Analogs of Lysophosphatidic Acid
… invasion, wound healing and angiogenesis. Autotaxin (ATX) was identified as an autocrine tumor cell motility factor from A2058 melanoma conditioned medium. ATX has lysophospholipase D enzyme activity and is responsible for the cleavage of lysophophatidylcholine (LPC) leading to the …
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The Biochemical Pathway Leading to Lpa Generation Upon Blood Coagulation
… regioisomeric preference of lysophospholipase D/autotaxin (ATX), which is the subsequent step in LPA production. To prevent acylmigration regioisomers of oleyl‑<em>sn</em>‑glycero‑3‑phosphocholine (LPAF) were synthesized. ATX preferred the <em>sn</em>‑<em>1</em> over the <em>sn</em>‑<em>2</em> …
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Contributions of viral and cellular gene products to the pathogenesis and prognosis of aggressive lymphomas
… that prognostic indicators including ATM, S1PR2, Autotaxin and EBV using immuno‐histochemistry techniques help with categorising aggressive lymphomas into different prognostic groups and does influence future management. In summary, my results showed there is a critical place for …
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Nfat1 Contributes to Melanoma Tumor Growth and Metastasis By Regulating Il-8 and Mmp-3
… have recently demonstrated that Gal-3 regulates autotaxin through NFAT1 and support melanoma progression. These findings prompted us to further study the role of NFAT1 in melanoma progression and metastasis. NFAT1 is a transcription factor that was first identified in immune cells, acting as a …
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The development of small molecule inhibitors for fibrosis drug discovery
… identified in recent years, including the enzyme autotaxin (ATX) and the RGD integrins, which are known to play a key role in the pathogenesis. In collaboration with GlaxoSmithKline, the projects detailed in this report were aimed to develop small molecule inhibitors with drug like physicochemical …
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The hypoxic tumor microenvironment regulates the LPA signaling axis to promote cancer cell invasion and metastasis
Le développement des métastases est la cause principale de mortalité des patients atteints de cancer, mais demeure un obstacle majeur aux traitements. L'hypoxie, une caractéristique commune des tumeurs solides, est fortement impliquée dans l'invasion cellulaire et le développement des métastases, …