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Showing 1 to 20 of 72 for “"autoregulation"”.
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A Dynamical Nephrovascular Model of Renal Autoregulation
… responses along the afferent arteriole, autoregulation under physiologic as well as pathophysiologic conditions, and renal oxygenation. A first attempt to model the impact of diabetes mellitus on renal hemodynamics is also made. Further, an application with clinical significance is …
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Mechanisms of Cerebral Autoregulation in Traumatic Brain Injury
… single centre studies. Studying Trends in AutoRegulation in Severe Head Injury in Paediatrics (STARSHIP) is the first multicentre prospective trial and aimed to characterise PRx in 135 children with pTBI. Firstly, I investigate the duration and magnitude of PRx disturbance following pTBI, …
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Pressure, Compliance, and Autoregulation Studies in Intracranial Dynamics
Advancements in neuromonitoring technologies and techniques have led to novel explorations into the physiology and management of traumatic brain injury and normal pressure hydrocephalus. This thesis investigated these pathologies, under approved ethical procedures, with the aid of advanced …
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The role of Ultrabithorax negative autoregulation in Drosophila melanogaster
… size. In Chapter 2, we describe how Ubx negative autoregulation establishes different Ubx levels in two different spatial domains of the developing haltere: the proximal haltere (which forms the joint and body wall in the adult) and the distal haltere (which forms the capitellum - the appendage …
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Autoregulation of the Glial Gene reversed polarity in Drosophila melanogaster
… while RBS2 and RBS3 appear to have no role in autoregulation of repo expression.
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Optimization of the assessment of cerebral autoregulation in neurocritical care unit
Introduction Cerebral autoregulation (CA) refers to the physiological mechanisms in the brain to maintain constant blood flow despite changes in cerebral perfusion pressure (CPP). It plays an important protective role against the danger of ischaemia or oedema of the brain. Over the years, various …
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The Baroreflex And Neurogenic Control Of Cerebral Autoregulation In Cerebral Blood Flow
Introduction The neurogenic component of cerebral autoregulation (CA) refers to those mechanisms controlling cerebral blood flow under the influence of the nervous system, and which rely on the innervation of the cerebral blood vessels. The neurogenic control of CA is incompletely understood. …
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Structural and Functional Basis for the Autoregulation of the Adaptor Protein TOM1
… the structural and functional basis of the autoregulation mechanism of TOM1 to switch from endosomal protein trafficking to the bacterial survival signaling pathway. Our thermal denaturation and spectroscopic studies demonstrate that PtdIns5P reduced thermostability, interhelical contacts, …
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Modeling and estimation for non-invasive monitoring of intracranial pressure and cerebrovascular autoregulation
… methods for the assessment of cerebrovascular autoregulation, which is the innate ability of the vasculature to maintain cerebral blood flow in the face of changes in cerebral perfusion pressure. Cerebrovascular autoregulation is often impaired in patients with brain trauma or stroke, and also …
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EVALUATION OF CEREBRAL AUTOREGULATION: FROM THE TRADITIONAL PRESSURE-FLOW INDEXES TO A DIRECTIONAL MULTIVARIATE ANALYSIS
L'autoregolazione cerebrovascolare (CA) è essenziale per la vita, poiché garantisce una stretta regolazione del flusso ematico cerebrale e, di conseguenza, un adeguato apporto di ossigeno al cervello. Il sistema cerebrovascolare funziona in modo bidirezionale: la pressione arteriosa media (MAP) …
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Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog
Thesis (M.S.)--Michigan State University. Dept. of Physiology, 1971
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Autoregulation of blood flow during sympathetic nerve stimulation in the arteriolar network on cat sartorius muscle.
Autoregulation is the tendency for blood flow to remain constant despite a change in arterial perfusion pressure. Flow regulation is achieved by adjustment of arteriolar caliber to the pressure change. The responses of arterioles are most commonly explained by either the metabolic or myogenic …
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Quantifying methodological uncertainties and navigating feasibilities in monitoring of cerebral autoregulation - Towards individualised management of TBI.
… advantage of such technologies like cerebral autoregulation (CA) monitoring, has the potential to improve outcomes by tailoring interventions to the unique physiological responses of each patient. However, a significant barrier to the widespread clinical use of CA-based metrics is the current …
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Autoregulation of Cortical Blood Flow in Response to Phenylephrine Induced Hypertension in the Normocapnic and Hypercapnic Cat
… of this research was to determine the degree of autoregulation of cortical blood flow in the cat, and to evaluate the usefulness of the heated thermocouple technique for measurement of local cortical blood flow. We determined the relationship between local flow and voltage output from our …
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Autoregulation of Xenopus estrogen receptor gene expression is mediated by a novel estrogen response element in the protein coding region
The induction of the Xenopus estrogen receptor mRNA by its ligand, estradiol-17$\beta$ (E$\sb2$), results in the establishment of a permanent autoregulatory loop. In order to identify the element(s) responsible for the long term regulation of the estrogen receptor gene, we cloned the estrogen …
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The impact of ischaemic preconditioning on cerebrovascular function in healthy individuals.
… CBF, cerebrovascular reactivity, cerebral autoregulation, and autoregulation during hypercapnia. Methods: Nine healthy participants (age 32.6±11.1 yrs; BMI 25.9±4.4 kg/m2) underwent two laboratory visits; RIPC and SHAM. RIPC consisted of 4 x 5 min periods of cuff inflation (to 200 mmHg) …
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Cerebral autoregulation in children with traumatic brain injury: Comparing the autoregulatory index (ARI) to pressure reactivity index (PRx) and their associations with cerebral physiological parameters
As an important hemodynamic mechanism, pressure autoregulation protects the brain against inappropriate fluctuations in cerebral blood flow subject to changing cerebral perfusion pressures. In acute neurological illnesses, including traumatic brain injury in children, impaired autoregulation is …
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Continuous Multi-Modal Monitoring of Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Impaired cerebral autoregulation following traumatic brain injury (TBI) in adults has been linked to worse global outcome. Continuously updating indices of cerebrovascular reactivity provide a convenient and continuous metric regarding an individual patients’ autoregulatory status. To date, the …
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Multimodality monitoring in paediatric severe traumatic brain injury : the contributions of brain oxygen, transcranial doppler and autoregulation monitoring to conventional methods on monitoring
Traumatic brain injury (TBI) is a highly complex clinical condition in the most complex organ of the body. The foundation of care of the patient with severe TBI is the prevention of secondary insults to the brain. This relies on conventional monitoring tools to identify patients at risk, but often …
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The BOLD MRI response of the brain to alterations in arterial blood pressure
… an important area of investigation. The cerebral autoregulation mechanism acts to maintain blood supply to the brain, despite changes in blood pressure. Blood flow alterations are closely linked to neuronal activation, and this activity can be visualised using blood oxygenation level dependent …
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