Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"autoreceptor"”.
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Behavioural microanalysis of dopamine autoreceptor function
Low doses of dopamine autoreceptor (DA) agonists are presumed to act by stimulating DA autoreceptors on the sona/dendrites and axon terminals of DA neurons. Low doses of apomorphine reduced food Intake, in a microstructural analysis paradigm, by reducing both the time spent feeding and the rate of …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… control over endogenous 5-HT release and 5-HT1A autoreceptor activation. Whole-cell intracellular recordings of DRN 5-HT neurons in in vitro brainstem slices revealed that light-induced 5-HT1A autoreceptor-mediated currents in chronically treated mice (14 days) were smaller in amplitude but …
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THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE
… seeking behavior. Stimulation of dopamine D3 autoreceptor reduces extracellular levels of dopamine. We tested the hypothesis that dopamine D3 receptor (D3R) gene deletion or its pharmacological blockade counteracts alcohol preference and intake in a long-term voluntary ethanol intake paradigm. …
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Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball
… that speedball combinations likely induced DA autoreceptor feedback in attempt to regulate increased [DA]<sub>e</sub>, and that there is also a significant increase in baseline reuptake rate by DAT following chronic speedball SA. In order to deduce the potential mechanism by which DAT is …
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THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
… (Leggio et al., 2016). D3R, acting as autoreceptor, regulates the activity of DAergic neurons throughout the mesolimbic, mesocortical and nigrostriatal DAergic pathways (Gobert et al., 1995; Tepper et al., 1997; Diaz et al., 2000). D3 deficient mice (D3R-/-) exhibit extracellular levels …
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Towards a Better Treatment of Parkinson's disease
… may, by selectively blocking the dopamine autoreceptor-mediated feedback inhibition of dopamine neurons, potentiate L-DOPA's effect on individual basal ganglia neurons and its antiparkinsonian effects in Parkinsonian animals. Electrophysiology (extracellular single-cell recording in the …
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An analysis of the role of midbrain dopamine systems in the suppression of tonic pain
… in midbrain ascending systems, induced by a low autoreceptor-specific dose of apomorphine, prevents the analgesic effect of intra-VTA morphine. The findings revealed throughout the present thesis suggest that part of a pain-suppression system that serves to inhibit tonic pain depends, at least in …
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Aspects of tic like behaviour and serotonergic control
… as an antagonist at the 5-HTlA somatodendritic autoreceptor and that (S)W A Y -100135 acts as a partial agonist at this site. Aspects of tic like behaviour and serotonergic control are discussed.
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The G protein-coupling specificity of D2-like dopamine receptors
… This perhaps reflects the role of D3 as an autoreceptor. Of particular interest was the demonstration that S-(-)-3PPP has both a higher efficacy and potency at the D3 receptor when coupled to Gαo1. The investigations into dopamine receptor-G protein coupling highlighted the utility of the …
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Präsynaptische Wirkungen von Cholinesterase-Hemmstoffen im Neocortex des Menschen und der Ratte
Die Alzheimer'sche Erkrankung wird auch heute noch hauptsächlich mit <br>Cholinesterase-Hemmern (AChEI) behandelt. Diese könnten jedoch auch indirekt - <br>nach der angestrebten Erhöhung der endogenen ACh-Spiegel - über muskarinische <br>Autorezeptoren die ACh-Freisetzung im Gehirn verringern. Um …
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS
… the control of receptor heteromers containing D2 autoreceptors and non-alpha7 nicotinic acetylcholine receptors (nAChRs). This evidence encouraged an in-depth investigation of the biochemical and functional interactions between dopaminergic autoreceptors and nAChRs containing the beta2 subunit. …