Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"autoradiography"”.
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Autoradiography of Photomembrane in HEMIGRAPSUS NUDUS
… cells of Hemigrapsus nudus by light microscope autoradiography. Two hours before sunset, crabs were injected with a single dose of tritiated leucine and sacrificed at time intervals coincident with dynamic retinal changes observed in electron microscope (EM) studies of related Arthropods (Blest, …
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Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… cerebral glucose uptake using 2-Deoxy-D-glucose autoradiography. We discovered that olanzapine attenuated central insulin-mediated cerebral glucose uptake across various regions of the brain. We also investigated whether this was a class or dopamine 2 receptor (D2R) antagonism driven effect by …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… was then evaluated in preliminary in vitro autoradiography and in vivo microPET (µPET) study using healthy rats. Fluorescence imaging using a Rhodamine B-Quin C1 fluorescent probe was conducted in parallel. In vitro fluorescence imaging studies showed increased binding of the Rhodamine …
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… dissertation demonstrated using [3H] WIN55,212-2 autoradiography and agonist-stimulated [35S]GTPγS autoradiography that this CBl receptor-specific reorganization results in corresponding functional changes manifested by alterations in CBl receptor binding and G-protein activation. These regionally …
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The neurobiology of parental behaviour of the ring dove (streptopelia risoria)
… behaviour. Quantitative 2-deoxyglucose (2DG) autoradiography at the onset of incubation revealed an increase in uptake in the nucleus preopticus medialis (POM), nucleus tuberis (NT) and nucleus ovoidalis (Ov). Quantitative 2DG autoradiography at late incubation and following treatment with …
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Development of PET Radiotracers for Imaging Neurodegeneration: Targeting alpha-Synuclein Fibrils and TSPO
… also been developed, and preliminary in vitro autoradiography studies and an in vivo microPET scan has been performed. For project 2, an automated radiosynthetic method was developed to produce [18F]GE387, a lead compound identified through collaboration with GE Healthcare. This radiotracer has …
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Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys
… Brains were processed for in vitro receptor autoradiography using [125I] Sauvagine and appropriate blockers to measure CRH receptor binding.
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Identity and dynamics of the microbial community responsible for carbon monoxide oxidation in marine environments
… incubation with radiolabeled CO, and the use of autoradiography to screen colonies with the desired phenotype. Cell-specific CO-oxidation activity is determined for selected purified strains with a time-series 14CO-oxidation method. Molecular phylogeny based on 16S-rDNA gene sequence information …
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
… molecular weight of 43 kDa (TDP-43). Utilizing autoradiography, a putative CSF-1R binding radioligand, [3H]CPPC, did not localize to microglia in the brain tissue of a preclinical model of neuroinflammation and percent displacement did not exceed 50% of signal, requiring use of spleen in …
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ΜΕΛΕΤΗ ΤΩΝ ΠΟΛΥΤΑΙΝΙΚΩΝ ΧΡΩΜΟΣΩΜΑΤΩΝ ΤΩΝ ΚΥΤΤΑΡΩΝ ΤΩΝ ΣΙΑΛΟΓΟΝΩΝ ΑΔΕΝΩΝ ΤΗΣ DROSOPHILA AURARIA
… THE DEVELOPMENTAL PROFILES OF ITS PUFFS AND BRS. AUTORADIOGRAPHY HAS BEEN PERFORMED IN ORDER TO CONFIRM THE RNA SYNTHESIS OF THE BRS DURING DEVELOPMENT. INFORMATION IS PRESENTED ON THE EXISTENCE OF TANDEM INVERTED DUPLICATIONS INVOLVING THE BRS REGIONS AND OTHERS OF THE CHROMOSOMES, AND DATA ARE …
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Investigation of the functional effects of two novel ampakines in the CNS
… semi-quantitative model of [14C]-2-deoxyglucose autoradiography in the C57Bl/6J mouse The first study sought to develop and characterise a model of [14C]-2-deoxyglucose autoradiography, to allow measurement of regional alterations in local cerebral glucose use (LCGU) in the mouse CNS. Following …
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Absorption, translocation, and fate of the herbicide, 2-(3,4- dichlorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5-dione, in cotton
… L. 'Acala 4-42-77') were studied using autoradiography, thin-layer chromatography, and counting. Foliar penetration and acropetal distribution of 14C occurred within 3 hr and increased with time. No basipetal translocation of ¹⁴C out of treated leaves was detected after treatment. …
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ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΧΟΡΙΟΓΕΝΕΣΗΣ ΣΕ ΕΝΤΟΜΑ ΟΙΚΟΝΟΜΙΚΗΣ ΣΗΜΑΣΙΑΣ
… OF FOLLICLES, WITH A RADIOACTIVE AMINOACID, AUTORADIOGRAPHY WITH PULSE-CHASE EXPERIMENTS, ONE AND TWO DIMENTIONAL ELECTROPHORESIS,AUTOFLUOROGRAPHY, SILVER STAINING METHOD OF GELS, IMMUNOCALIZATION OF PEROXIDASE WITH WESTERN BLOTTING AND DOUBLE ANTIBODY STAINING, PEROXIDASE LOCALIZATION IN THE …
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The Membrane Polypeptides of the Vacuolar System: Composition and Recycling
… found in lipids. Cell viability remained> 99%. Autoradiography at both the light and EM level revealed that > 97% of the cells were labeled, and quantitative analysis demonstrated the localization of grains to LPO-latex containing PL. PL were separated on sucrose gradients, and their radiolabel …
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Autoradiographische Untersuchungen zur Toxikokinetik von Myosmin in Ratten
… and albino rats by quantitative whole-body autoradiography. One rat each was sacrificed by CO2 asphyxiation six and 15 minutes as well as 1, 4 and 24 hours after intravenous injection Zusammenfassung / Summary 91 of myosmine (5-3H: 1.4 µg/kg; 8.49 MBq/kg or 2’-14C: 0.27 mg/kg; 3.74 MBq/kg). …
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Investigating disturbances of brain 5-HT systems by experimental MRI and SPECT neuroimaging
… to interact with the serotonin system, in vitro autoradiography of SERT in mice with widespread hypomyelination was conducted in order to test this hypothesis. Lastly, in a rat model of SERT depletion, the relative abilities of a well established SPECT radioligand, [125I]βCIT …
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Studies on the Teichoic Acids of the Pneumococcus
… cells over several generations was followed by autoradiography. The results confirm the zonal growth model for Gram-positive coccal cells. In Part II, the pneumococcal Forssman antigen is identified as a membrane lipoteichoic acid. The following lines of evidence suggest that the teichoic acid …
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A Rat Model Examining Behavioral and Neurochemical Effects of Passive Exposure to Aggression on Observers
… over 16 days. Next, radioimmunoassay and autoradiography were used to test the levels of serum testosterone and corticosterone, as well as the densities of dopamine D2 receptors and 5-HT1B receptors, among observer rats chronically exposed to aggression or non-aggression. No differences in …
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Site Directed Mutagenesis of a Putative Protease Cleavage Site Within the 105 Kilodation Protein of Southern Bean Mosaic Virus
… and the cleavage patterns were detected after autoradiography. Two substitutions of the C60 QS pair-Pro-Val (PS) in mutant6, Gin-Pro (QP) in mutant19-reduced the yield of the 60 KDa protein by different levels. This result supports the hypothesis that the C60 QS is a cleavage site.
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Mechanistic investigation of polyhydroxybutyrate (PHB) synthases and elucidation of PHB biosynthesis and degradation process in Wautersia eutropha H16
… Westerns with PHA and PhaCPhaEAv antibodies, and autoradiography showed different migratory properties of the mutant synthase after its reaction with substrate at various substrate to enzyme ratios (S/E). These results indicate that PhaCAv has been modified with hydroxybutyrate oligomers ((HB)n). …
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