Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"autophagy-lysosome pathway"”.
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An integrated multi-omics approach to improve our understanding of ageing and neurodegeneration
… data types along with their integration at the pathway level. From our transcriptomics analysis on 84 healthy individuals across the human life span, we identified that the astrocytes in prefrontal cortex assist in brain development and switch their function from being neuroprotective to …
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Investigation of selected autophagic proteins and the effect of tPS1-GFP expression.
… for the cell to exist. One of the most important pathways by which the largest number of cytosolic and misfolded proteins is degraded is the autophagy-lysosome pathway. A defect in this process may result in accumulation and aggregation of proteins leading to cellular toxicity and subsequently …
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A NOVEL RIT2-LRRK2 AXIS MODULATES LYSOSOME FUNCTION: INSIGHT FOR PARKINSON'S DISEASE PATHOPHYSIOLOGY
La disfunzione lisosomiale è un fattore determinante nella patogenesi della malattia di Parkinson (PD). L’attività chinasica di Leucine-rich repeat kinase 2 (LRRK2) modula autofagia e funzionalità lisosomiale, e la sua inibizione farmacologica è protettiva per neurodegenerazione e patologia di …