Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"automated synthesis"”.
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Automated Synthesis of Duplex-Forming Recognition-Encoded Oligomers
… are a promising candidate for such a system. An automated solid-phase synthesis (SPS) route was optimised to yield high-purity REMOs with precise sequence control. Loaded Wang resin was reacted alternatingly with piperazine and dichlorotriazine monomers, appended with phenol donor (D) or …
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Toward the automated synthesis of carbohydrates and glycosaminoglycans
… with most complex polysaccharides, the chemical synthesis of glycosaminoglycan structures is challenging. This thesis describes efforts towards the construction of oligosaccharides with the ultimate goal of the automated synthesis of glycosaminoglycans. The use of glycosyl phosphates of …
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Automated synthesis of the Lewis blood group oligosaccharides
… monitoring of each glycosylation reaction during automated solid-phase oligosaccharide synthesis allowed for the rapid synthesis of three Lewis-type cell surface oligosaccharides. The assembly of the nonasaccharide adenocarcinoma marker Le[superscript]y-Le[superscript]x monosaccharide building …
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Automated synthesis of mixed-technology MEMS systems with electronic control
… of corresponding analogue and mixed-technology synthesis methodologies is still lagging behind. Therefore, there is an increasing need for automated synthesis techniques that can reduce the development cycle and facilitate the generation of optimal configurations. This research investigates and …
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Automated synthesis and evaluation of potential new anti-microbial agents
… was prepared in an automated fashion, and tested against Mycobacterium fortuitum in a rapid screen for antimycobacterial activity. Many of the compounds from this series were also tested against Mycobacterium tuberculosis, and the usefulness as M.fortuitum as a rapid, …
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Automated Synthesis Procedure Generation in Heterogeneous Catalysis via Fine-Tuned Language Models
The exploration of catalytic materials and their synthesis routes traditionally demands extensive iterative experimentation and significant time investment. To overcome these constraints, we have developed an advanced extraction workflow integrating language models and multimodal processing …
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Automated synthesis of low-rank stochastic dynamical systems using the tensor-train decomposition
… to events in real-time. Thus, the goal of automated synthesis is to construct a controller that provably implements a range of behaviors given by a specification of how the system should operate. Unfortunately, many approaches to automated synthesis are ad hoc and are limited to simple …
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Development of A Multi-Purpose Automated Synthesis Module For Production of Novel Pet Radiopharmaceuticals
… (<sup>18</sup>F-FDG) made from commercialized automated synthesis module is the most frequently used in tumor diagnoses. But the false positive findings, such as infectious tissues and post-operative surgical conditions, show strong uptake of <sup>18</sup>F-FDG in PET scans which requires extra …
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Automated synthesis and NULL cycle reduction optimization for asynchronous NULL convention circuits using industry-standard CAD tools
… for System-on-Chip (SoC) design, the lack of an automated design flow continues to prevent its widespread usage in the semiconductor industry. A novel circuit synthesis algorithm and an automated throughput enhancement technique have been developed and integrated into the industry-standard Mentor …
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Architecture synthesis for adaptive multiprocessor systems on chip
This thesis presents methods for automated synthesis of flexible chip multiprocessor systems from parallel programs targeted at FPGAs to exploit both task-level parallelism and architecture customization. Automated synthesis is necessitated by the complexity of the design space. A detailed …
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A small molecule synthesizer
… over the last two centuries, small molecule synthesis remains a relatively complex, unsystematized, and time-intensive process practiced almost exclusively by highly trained specialists. Collectively, these limitations represent a major bottleneck in the efforts to study, understand, and …
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Artificial Intelligence-Aided Synthesis and Characterization of 2D Materials
… an autonomous platform to accelerate 2D material synthesis with four distinct projects. First, we employ named entity recognition (NER) and extractive question-answering (EQA) models to extract experimental recipes, including categorical and numerical data, illustrating how to trace the …
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Studies of recognition and selectivity by fluorescent polymers imprinted with N1-benzylidene pyridine-2-carboxamidrazones
As part of a programme of automated synthesis and biological screening, new fluorescent polymers imprinted with various N¹-benzylidene pyridine-2- carboxamidrazones have been successfully constructed and evaluated for their recognition of the original template and cross-reactivity to similar test …
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Design, Synthesis And Characterization Of Lipidated Pna-Peptide Conjugates As Potentialtherapeutic And Diagnostic Reagents
… and biological properties. After solid-phase automated synthesis, PNA-CPPs: TAT/Arg9) were coupled with lipids or phospholipids before cleavage from the support and then purified by HPLC. The conjugates were characterized by UV-vis and MALDI, and by their ability to form vesicles in water and …
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Development of safety health monitoring device to prevent and control risk in confined space
… and provide a supporting platform for the automated synthesis of interoperability software artifacts. Such artifacts enable the interconnection between mobile Things that employ heterogeneous middleware protocols. Our platform further supports evaluating the effectiveness of the …
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Modeling middleware platform for supporting communication between IoT devices
… and provide a supporting platform for the automated synthesis of interoperability software artifacts. Such artifacts enable the interconnection between mobile Things that employ heterogeneous middleware protocols. Our platform further supports evaluating the effectiveness of the …
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Fluorescent anthracene tags for detection of base pair mismatches in DNA duplexes
… phosphoramidites 5a and 5b have been synthesised. 5b has been incorporated into oligonucleotide sequences (PrA, PrB, PrC, PrD, PrE, PrF and PrG) as a DNA base analogue using automated synthesis. Melting temperature (T\(_m\)) studies of double-stranded 15-mer / 14-mer deletion sequences …
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Learning Program Specifications from Sample Runs
… we present a recent line of work on automated synthesis of specifications that overcome many of the deficiencies that plague existing specification inference methods. Our main contribution is a formulation of the problem as a sample driven one, in which specifications, represented as …
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Intrinsic Hardware Evolution on the Transistor Level
This thesis presents a novel approach to the automated synthesis of analog circuits. Evolutionary algorithms are used in conjunction with a fitness evaluation on a dedicated ASIC that serves as the analog substrate for the newly bred candidate solutions. The advantage of evaluating the candidate …
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Design of a second generation MIDA boronate: iterating c(sp3) based Suzuki cross couplings
… society in general. Despite this, small molecule synthesis is still a time and cost intensive process practiced primarily by highly trained specialists. Inspired by the impact of general, automated synthesis platforms for peptides and other biomolecules, we have pioneered iterative cross coupling …
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