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Showing 1 to 18 of 18 for “"autologous bone"”.
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In-vivo-Testung eines neuartigen bFGF/TCP-Composite
Autologous bone graft is the golden standard for bone replacement materials. Unfortunately it is limited and has side effects in about 10%. Aim of the study was to determine bone-regenerative effects of a new bFGF/TCP-composite, consisting of basic fibroblast growth factor and a newly developed, …
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Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow
The current gold standard for bone graft material is autologous bone, which provides mechanical support, possesses factors that promote bone formation, and contains connective tissue progenitors (CTPs), a heterogeneous population of connective tissue stem and progenitor cells that contribute to …
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In-vivo-Testung eines neuartigen BMP-2/TCP-Composite
The aim of the study was to determine bone-regenerative effects of an in situ setting tricalcium phosphate (TCP) cement combined with rhBMP-2 and to compare it with autologous bone graft. A trepanation defect of 1.5 mm in the femur diaphysis of Sprague-Dawley rats was filled with TCP cement …
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Terapia celular na pseudo-artrose
… cell therapy for pseudoarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemnporaneously using the Sepax® equipment. Seven patients with nonunion of the tibia or femur were treated. Five received a percutaneous infusion of autologous bone marrow aspirated …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
Autologous bone marrow grafting has been shown to aid in the healing of bone defects since the 1950s. Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative to harvest and transplantation of autologous bone for treatment of large …
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Bone Marrow-Derived Buffy Coat Can Supplement the Bone Marrow Stimulation Technique for Articular Cartilage Repair
" Bone Marrow-Derived Buffy Coat Can Supplement the Bone Marrow Stimulation Technique for Articular Cartilage Repair Bone marrow stimulation (BMS) has been used as a popular operating technique to repair defect of knee articular cartilage. However, the regenerated tissue from BMS is known as a …
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Engineering Musculoskeletal Tissue: In vitro and in vivo evaluation of novel scaffolds and growth factors for bone regeneration
… The management of bony non-unions and large bone defects due to congenital deformities, trauma, degenerative disease, and oncological resection remains a complex challenge for orthopaedic surgeons. Currently, autologous bone grafting is the ‘gold standard’ treatment for non-unions and large …
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In vitro and in vivo assessments of PCL-TCP composites for bone tissue engineering
Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. Autologous bone graft poses no issues of rejection but will result in donor site morbidity and is limited by defect size. Allografts and xenografts are …
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TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING
… trauma, but better options for treatment of bone injuries resulting in bony defects are still needed. Autologous bone grafts remain the standard treatment for segmental defects and non-unions. Engineered bone graft substitutes have failed to promote sufficient bone formation in large defects. …
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Management of cartilage deficiency by applying extracellular matrix membrane on bone marrow stimulation technique and evaluating the quality of repaired cartilage
… using extracellular matrix (ECM) membrane on bone marrow stimulation (BMS) techic and development of a novel analytic method for detection of engineered cartilage. Chapter Ⅰ: BMS has been regarded as a first line procedure for repair of articular cartilage. However, repaired cartilage from BMS …
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Hyaluronsäure als Trägersubstanz für bioaktive Proteine zur Optimierung der Knochendefektheilung
… years the progress made in the understanding of bone metabolism and the possibility of producing macromolecules have led to new methods being used in the treatment of bone defects. Basic fibroblast growth factor (100µg), an extremely potent mitogen or bone morphogenetic protein (100µg), whose …
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Exercise and activity patterns in cancer patients after recent allogeneic bone marrow transplatation
Exercise following autologous bone marrow/ peripheral blood stem cell transplants (BMT/PBSCT) may decrease fatigue and loss of physical function that usually occur post-transplant. However, there is little empirical data regarding the effect of exercise on activity levels and symptom severity …
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Exercise and activity patterns in cancer patients after recent allogeneic bone marrow transplatation
Exercise following autologous bone marrow/ peripheral blood stem cell transplants (BMT/PBSCT) may decrease fatigue and loss of physical function that usually occur post-transplant. However, there is little empirical data regarding the effect of exercise on activity levels and symptom severity …
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Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
… uneventfully but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are …
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Put Your Back Into It: A Structural and Mechanical Characterization of Iliac Crest and Cervical Spine Autograft for ACDF Surgeries
… procedures performed worldwide. ACDF utilizes autologous bone graft (autograft) from the iliac crest to induce fusion between neighboring vertebrae following the procedure. The iliac crest is widely considered the gold-standard autograft for ACDF procedures due to its osteoinductive, …
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Preclinical Evaluation of 3D Printed Biomaterials for Repairing Critical-Size Bone Defects
… of patients each year suffer from non-healing bone defects secondary to trauma, cancer, osteomyelitis, or congenital anomalies. The standard of care for managing these cases necessitates bone reconstruction surgery. Although using autologous bone (autograft) or banked cadaveric bone (allograft) …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… multi-agent chemotherapy, radiation, and autologous bone marrow transplant. Novel therapeutic modalities are under development. The camptothecin analogs topotecan and irinotecan have been identified as successful cytotoxic agents. For topotecan, pharmacokinetically guided dosing to achieve …
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NETWORK META-ANALYSIS OF ORAL AND MAXILLOFACIAL REGENERATION PROCEDURES
… effective grafting/sealing biomaterial for new bone formation after alveolar ridge preservation; 3. to determine the most effective biomaterial for soft tissue regeneration after tooth extraction; 4. to determine the most effective biomaterial for gingival recession treatment in adjunct to …