Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"autoinducers"”.
-
The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates
… using a similar approach, but using bacterial autoinducers instead of siderophores. Autoinducers are required for coordination of bacterial behaviours and are involved in the control of swarming, virulence factor production and biofilm formation. The quorum sensing molecules produced by …
-
Mutant analysis of luminescence and autoinduction in a marine bacterium
… the mutants revealed the presence of multiple autoinducers and autoinducer synthases in V. fischeri. One of the autoinducers (autoinducer-2, or AI-2) was chemically purified and shown to be Noctanoyi- L-homoserine lactone. The genetic locus encoding the AI-2 synthase was cloned and designated …
-
Identification of Quorum Sensing Genes in Halococcus Hamelinensis SP. Nov. 100Na1
… releasing chemical and protein signals called autoinducers in order to control and regulate specific gene expression. The process of cell-to-cell communication is termed quorum sensing (QS). According to cell density, if a specific threshold concentration of autoinducers is reached, the …
-
Identification of Quorum Sensing Genes in Hypersaline Microbial Mats
… diffusible signaling molecules referred to as autoinducers. This pathway ultimately coordinates gene expression among the bacterial community leading to synchronized behaviors in a multicellular fashion. Quorum sensing is known to be controlled by synthases of autoinducers and transcriptional …
-
Studying the Competence Regulon Quorum Sensing Circuity in Streptococcus mitis
… and release chemical signal molecules known as autoinducers, which increase in concentration as cell density increases. To determine the cell density and initiate the group behaviors such as virulence factor production, biofilm formation, and competence development bacteria rely on the …
-
Sympatric Soil Microbe Interactions between Streptomyces and Fusarium Isolates
… to conditioned media which likely contained autoinducers from mature S2-2 culture was shown to cause a significant increase in antifungal production earlier than control groups. Simultaneous inoculation of S2-2 and <em>Fusarium</em> isolate F10-8 was shown to cause a significant decrease in …
-
Biochemical Evaluation of SRH Analogs as Potential LuxS Inhibitors
… facilitated by small molecules called autoinducers. Interspecies quorum sensing is facilitated by the autoinducer AI-2. The enzyme LuxS catalyzes the formation of AI-2 from <em>S</em>-ribosyl homocysteine (SRH) in a wide variety of bacterial species. Inhibition of LuxS would therefore …
-
The ecology of prophages at the microscale
… community members – namely, quorum sensing autoinducers. Through a large-scale genomic survey of prophages and their hosts across the bacterial domain, I estimated the extent to which prophages co-opt quorum sensing systems by encoding their components as auxiliary genes. Collectively, this …
-
Mathematical Models of Quorum Sensing
… communication are mediated by molecules called autoinducers that are both synthesized and collected by quorum sensing bacteria. We employ differential equations to investigate and understand the dynamics of underlying signaling processes. The first two models of this study were constructed with …
-
Characterization of QSEA and QSED in the Quorum Sensing Cascade of Enterohemorrhagic Escherichia Coli
… by which bacteria use chemical signals, termed autoinducers, to regulate key genes. In the gastrointestinal tract, EHEC responds to AI-3 produced by the endogenous gastrointestinal microbial flora and epinephrine/norepinephrine produced by the host to regulate expression of virulence genes. In …
-
I. Stereochemical Control of Chiral Assembly and Liquid Crystal Phase Formation of Nonamphiphilic Molecules in Water II. Control Bacterial Quorum Sensing and Quorum Sensing-mediated Activities Using Small Unnatural Molecules
… lactones (SHLs) as analogues to the natural autoinducers N-acyl homoserine lactones (AHL) in Gram-negative bacteria. These SHLs were shown to have no or minimal impact of the growth of P. aeruginosa and V. fischeri, but maintain the abilities to modulate quorum sensing and inhibit biofilm …
-
Controlling Biofouling by Surface Engineering and Molecular Inhibition
… for a class of organic molecules called autoinducers secreted by bacteria, which are responsible for regulating bacterial group behavior such as biofilm formation. Chapter 6 reports the synthesis of derivatives of a class of molecules called brominated furanones, which are known to …
-
The Influence of Changes In theMolecular Structure of N-Acylhomoserine Lactones On the Complexation and Dna-Binding of Luxr Protein
… to surrounding chemical signals known as autoinducers. A wide range of Gram-negative Proteobacteria possess LuxR-type transcriptional regulatory proteins which can perceive and bind cognate autoinducer N-acylhomoserine lactones (AHLs), thereby inducing a conformational change and …
-
The Functional Characterization of the LysR-Type Transcriptional Regulator QseD and the SorC-Type Transcriptional Regulator LsrR in Enterohemorrhagic Escherichia coli
… through the recognition of bacterially produced autoinducers (AI) AI-2, and 3 by LsrR, and QseBC respectively [1, 3]. Through the interpretation and integration of these multiple regulatory signaling networks that often involve intracellular regulatory proteins, such as the lysine regulator …