Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 274 for “"autoimmunity"”.
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Preeclampsia, Autoimmunity and The At1 Receptor
<p>Preeclampsia (PE) is a disease of late pregnancy characterized by maternal hypertension and proteinuria. It is associated with preterm delivery and significant perinatal morbidity and mortality. Despite affecting ~7% of first pregnancies, there is no effective screening method to identify women …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
<p>Humoral autoimmunity is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus …
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Triggers of autoimmunity. Studies on gestational events.
… to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of developing celiac …
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Aspects of T cell development contributing to autoimmunity.
Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. …
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Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
The goal of a therapy against autoimmune diseases would be to blunt immune responses against self antigens, without impairing systemic immunity. Our lab has been developing a nanoparticle-based therapy which consists of disease-relevant peptide-MHC complexes coated on iron-oxide nanoparticles …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
As a means to understand the significance of transcriptional regulation of Th cells in MS pathogenesis, we investigated the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a …
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… proband had not only TB but also multi-organ autoimmunity and died of autoimmune pneumonitis at age 11 years. His older brother also had type 1 diabetes and died of pneumonitis of undocumented etiology at age 3 years. Moreover, I had an opportunity to study another two siblings with inherited …
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GENETIC REQUIREMENTS OF DANGEROUS MIX AUTOIMMUNITY IN ARABIDOPSIS THALIANA
Autoimmunity is often found in hybrid plants due to uncontrolled immune responses without obvious pathogenic attacks. Due to the characteristic strong phenotype of hybrid necrosis, it has been successful in identifying DANGEROUS MIX (DM) genes in Arabidopsis thaliana, consisting of two incompatible …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human counterparts; experimental autoimmune encephalomyelitis (EAE) – a model for MS, and collagen induced arthritis (CIA) and antigen induced arthritis (AIA) – models for RA. A …
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The bi-directional relationship between gut microbiota and autoimmunity
… thus modulating immunological function. Autoimmunity is a state in which there are aberrant immune responses produced against host tissue. Intestinal bacteria are directly impacted by instances of inflammation brought on by autoimmunity. The complicated nature between autoimmunity and …
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Nasal Associated Lymphoid Tissue in health, infection and autoimmunity
The immune system exists in three core components - epithelial surface barrier immunity to prevent entry of foreign antigens from the environment; innate immunity to provide an immediate but non-specific cellular immune defence response to foreign antigens; and an adaptive immune response providing …
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Structural and Biochemical Studies of Nisin *Biosynthesis and Autoimmunity
… well as insights into how L. lactis demonstrates autoimmunity to the lantibiotic nisin.
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… diseases. The rodent model of Hg-induced autoimmunity is useful for the analysis of systemic autoimmunity that is both environmentally and genetically modulated. In susceptible mice, Hg treatment induces both polyclonal activation of B cells, as well as the production of highly specific …
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The Biology of Dendritic Cells in the Context of Autoimmunity
… behind how exactly how pDCs contribute to lupus autoimmunity is unknown, contributing to the current dearth lack of disease modifying treatments; current treatments only succeed in suppressing symptoms, and do not halt disease progression. In this study, we take a multifactorial approach to …
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Interplay of Antibody Responses to Closely Related Viruses and Autoimmunity
… the precise contributions of viral infections to autoimmunity remain elusive. The presence of autoreactive antibodies is associated with an increased risk of developing autoimmune disease. Thus, analyzing the impact of viral infection and vaccination on the development of autoreactive antibodies …
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The Role of Drak2 in T Cell Function and Autoimmunity
… Drak2 plays an important role in eliciting autoimmunity, rather than preventing it. This is demonstrated by the finding that <em>Drak2<sup>-/-</sup></em> mice are resistant to autoimmune disease in mouse models of T1D and MS. This resistance is due to reduced accumulation of …
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The Hu Syndrome: At the Intersection of Cancer and Autoimmunity
… behind both tumor immunity and neuronal autoimmunity. The Hu syndrome is an example of PND that affects patients with small cell lung cancer (SCLC). Hu patients are diagnosed by the presence of antibodies in the blood that recognize the HuD antigen. HuD is normally restricted in …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of …
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The Function of LAT in T Cell Activation and Autoimmunity
<p>LAT (linker for activation of T cells) is an important transmembrane adaptor protein in TCR-mediated signaling. Upon TCR engagement, LAT associates with multiple proteins which allows for the activation of downstream signaling pathways. The interaction between LAT with phospholipase C …
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Mathematical models of immune responses during external challenges and autoimmunity
… immune system and its response to infection and autoimmunity is crucial for understanding and predicting disease outcomes and evaluating potential interventions at multiple scales. While data provide a snapshot of certain biological phenomena, they cannot capture the underlying dynamics. Despite …
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