Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 229 for “"autoimmune diseases"”.
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… to be manipulated for therapeutic benefit in autoimmune and inflammatory disorders, such as neurodegenerative diseases.</p> <p>Foxp3-expressing regulatory T (Treg) cells are specialized immunosuppressive cells that establish immune tolerance to prevent the development of autoimmune and other …
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Biomarker Discovery in Autoimmune Diseases: A Proteomics Approach
… profiling studies were performed on two autoimmune diseases. Protein profiles with high mass peak fidelity were obtained with high discriminatory power. Selective differential peaks were further investigated and confirmed to display differential levels in clinical samples. Validation in a …
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Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases
… a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis with both anticitrullinated protein antibodies (ACPA) and …
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Identification of viral and bacterial triggers for human autoimmune diseases
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
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Statistical Techniques to Fine Map the Related Genetic Aetiology of Autoimmune Diseases
… many genetic regions which are associated with autoimmune disease risk. In this thesis, I present methods which I have developed to build upon these studies and enable the analysis of the causal variants of these diseases. Colocalization methods disentangle whether potential causal variants are …
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The Use of Surface Cytokines as Biomarkers in B Cell Mediated Autoimmune Diseases
<p>RA and SLE are B cell-mediated autoimmune diseases dominated by autoantibodies that affect over 1.5 million Americans. Together RA and SLE contribute to over 29 billion in healthcare costs, therefore due to the high financial burden and physical toll of these diseases on the population, there is …
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Spiritual Direction with Women Who Have Autoimmune Diseases: A Model of Psychospiritual Care
… lupus erythematosus (lupus) are incurable autoimmune diseases affecting a growing number of people in the U.S. Women typically receive medical care for the physical effects of these diseases, but psychospiritual dimensions of illness experiences are often neglected. Common autoimmune …
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POPULATION GENETIC APPROACHES FOR THE STUDY OF COMPLEX TRAITS: FOCUS ON INFECTIOUS AND AUTOIMMUNE DISEASES
It is commonly believed that infectious diseases have represented one of the major threats to human populations and have therefore acted as a powerful selective force. Therefore, several human genes have evolved in response to infectious agents. Indeed, it has been suggested that human populations …
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Drug design strategies for modulating immune activity for the treatment of autoimmune diseases and cancer
… to normal tissue, and lead to the development of autoimmune diseases. Moreover, damaged cells may utilize these self-tolerance mechanisms to avoid detection and suppress the immune response, resulting in the development of cancer. In this dissertation, we considered the physiochemical properties …
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The Association between Symptoms of Autoimmune Diseases and Circadian Clock Disruption: A Pilot Study Using Only Healthy Controls
Autoimmune disease occurs when the immune system attacks self-molecules. It ranges from organ-specific to systemic, including Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), and Sjogren’s Syndrome (SS). Evidence indicates disturbances of the circadian clock to demonstrate detrimental effects on …
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Role of biopsychosocial variables in predicting positive well-being and health-promoting behaviors in individuals with autoimmune diseases.
… health-promoting behaviors in individuals with autoimmune diseases. The predictors included disease severity, depression, arthritis self-efficacy, and social support. The dependent variables were positive well-being and health-promoting behaviors. Participants included 175 individuals with …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… cells have been linked to the development of autoimmune diseases. The glycoprotein CD1d plays an integral part in the recognition and presentation of lipid antigens such as α-galactosylceramide (α-GalCer) to iNKT cells, producing a variety of anti-inflammatory (T\(_H\)2) cytokines, such as …
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FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… mortality rates, systemic sclerosis (SSc) is an autoimmune disorder characterized by vasculopathy, inflammation, progressive perivascular and interstitial fibrosis. SSc pathogenesis is largely unknown, however strong evidences suggest that genetic predisposition may contribute to SSc development. …
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… for environmental factors in the pathogenesis of autoimmune diseases in humans and animals. Correlations have been made between mercury (Hg) exposure and the prevalence human autoimmune diseases. The rodent model of Hg-induced autoimmunity is useful for the analysis of systemic autoimmunity that …
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How Rubies are Formed: The Overlap Between Sexual Violence Trauma and Autoimmunity
… relationship between sexual violence trauma and autoimmune disease in tandem with my probing of my relationship to my mother from childhood to adulthood. This work creatively extends upon the knowledge that approximately four-fifths of those afflicted by autoimmune diseases are women. The link …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
The ultimate goal in the treatment of autoimmune diseases is to reestablish tolerance to self antigens. One strategy to induce tolerance is to express the target autoantigen by DNA vaccination. In this work, the potential of vaccination with a DNA construct encoding the myelin oligodendrocyte …
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Where Birds Go to Die, a Memoir
… cope with his father's suicide and his mother's autoimmune diseases, which finally claimed her life after a 14-year fight.</p>
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An Immunologic Investigation of Bisalbuminemia : A Genetically Transmitted Serum Protein Anomaly
… and connective tissue (collagen) and/or autoimmune diseases. Physiochemical properties of the anomalous albumin fraction were compared to normal serum albumin. Procedure. Cellulose acetate electrophoresis was used to determine the genotypes from which was established the genetic pedigree …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
… are associated with antibody-mediated autoimmune diseases in humans including systemic lupus erythematosus (SLE). Numeral and functional aberrations of T regulatory T (Treg) cells are common in patients with autoimmune diseases. Although different types of immunosuppressive agents have …
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A COHORT STUDY INVESTIGATING AUTOANTIBODY LEVELS DURING AND AFTER INFECTION WITH INFLUENZA A VIRUS
… are present in all individuals. In those with autoimmune diseases they are routinely present in elevated levels. Although the nature and development of autoimmune diseases are not fully understood there are many hypotheses as to possible causes of an autoimmune disorder. One possible cause is …
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