Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 200 for “"autoimmune disease"”.
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The Gelatinases and Autoimmune Disease
… the same ones that contribute to their role in autoimmune disease. While MMPs are best known for being dysregulated in chronic disease states, they also have the ability to contribute to disease onset. There are highly specific regulatory differences among MMPs. This is how the proper MMP is …
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The modulation of autoimmune disease progression in mouse models
… roles in the development of the two human autoimmune diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are temporary and …
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Development of an efficient test for autoimmune disease using gold nanoparticles
Coeliac disease results because of an unusual immune response to the digestion of gliadin protein. Patients suffering from the disease show varying degrees of chronic inflammation within the small intestine ranging from mild lesions to completely flat mucosa. The immune response in turn, leads to …
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
… shown BAFF to be involved in the pathogenesis of autoimmune diseases, including Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis. In an effort to understand the role of BAFF in the pathogenesis of autoimmune diseases, extensive in vitro studies on primary B cells have been performed. A …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… destruction/disruption commonly associated with autoimmune disorders. Consistent with this, there is increasing evidence supporting an inverse relationship between worm infection and Th1/17-based inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes and …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
Multiple Sclerosis (MS) is a disease, which presents with neurological dysfunction and is believed to have an immunological etiology. Lesions in the central nervous system (CNS) are characterized by an inflammatory cellular infiltration and demyelination of neuronal axons. It is believed that …
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
… cell receptor and a cognate-ligand developed an autoimmune disease, the pathology of which was reminiscent of psoriasis. The disease was strictly dependent on the presence of both the T cell receptor and antigen. Interestingly, only certain inbred strains of mice developed the disease. The …
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Investigations into the role of exogenous estrogenic endocrine disrupting chemicals on immune dysregulation in autoimmune disease
… the immunomodulatory effects of this EEDC. Autoimmune diseases, such as systemic lupus erythematosus (SLE), are characterized by a dysregulated immune system that has lost tolerance to self-antigens. The pathogenesis of SLE is still poorly understood. However, it is likely that genetics, …
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Characterization of Anti-Dna Antibody Purified From Sera of Patients With the Autoimmune Disease Systemic Lupus Erythematosus
Made available in DSpace on 2014-12-11T18:16:58Z (GMT). No. of bitstreams: 1 7514140.pdf: 6330150 bytes, checksum: 186f6d46446050cc341de0aa6d50f312 (MD5) Previous issue date: 1975
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The TREX1 3' Exonuclease and Autoimmune Disease: Structural and Biochemical Analysis of Disease Mutants Involved in Autoimmune Dysfunction
… Trex1 gene are the underlying cause of multiple autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), and retinal vasculopathy and cerebral leukodystrophy (RVCL). Several cellular roles have been proposed for TREX1 …
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TREX1 AUTOIMMUNE DISEASE MUTANTS REVEAL DIMERIC STRUCTURE REQUIREMENTS AND THE C-TERMINAL REGION OF TREX1 CONTROLS CELL LOCALIZATION THROUGH UBIQUITINATION
… in the TREX1 3'' exonuclease cause a spectrum of autoimmune disorders in humans. In this study, we elucidate how structural features of TREX1 that are necessary for normal TREX1 biological function are perturbed and lead to disease. TREX1 is a homodimeric enzyme, and the Arg-114 residue …
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Biological effects of synthetic biomolecules that may either mimic or antagonise the function of hCG in the development of cancer and autoimmune disease
… tolerance, offering applications in treating autoimmune diseases. Conversely, antagonistic aptamers like A2 may block hCG-mediated immune suppression, providing a novel approach to treating hCG-secreting tumours by reactivating anti-tumour immunity.
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Interplay of Antibody Responses to Closely Related Viruses and Autoimmunity
… may also bind to self-antigens and contribute to autoimmune disease. While pathogen infections have been associated with development of autoimmune diseases, the precise contributions of viral infections to autoimmunity remain elusive. The presence of autoreactive antibodies is associated with an …
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How Rubies are Formed: The Overlap Between Sexual Violence Trauma and Autoimmunity
… relationship between sexual violence trauma and autoimmune disease in tandem with my probing of my relationship to my mother from childhood to adulthood. This work creatively extends upon the knowledge that approximately four-fifths of those afflicted by autoimmune diseases are women. The link …
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Role of biopsychosocial variables in predicting positive well-being and health-promoting behaviors in individuals with autoimmune diseases.
… health-promoting behaviors in individuals with autoimmune diseases. The predictors included disease severity, depression, arthritis self-efficacy, and social support. The dependent variables were positive well-being and health-promoting behaviors. Participants included 175 individuals with …
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Effect of tolerogenic peptide administration on pathogenic antigen-experienced T cells
… auto-reactive CD4+ T cells involved in driving autoimmune disease pathogenesis, whilst leaving the rest of the immune system intact. The prophylactic administration of soluble autoantigen-derived peptides has proven to be effective at inhibiting disease induction in various experimental models …
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The Association between Symptoms of Autoimmune Diseases and Circadian Clock Disruption: A Pilot Study Using Only Healthy Controls
Autoimmune disease occurs when the immune system attacks self-molecules. It ranges from organ-specific to systemic, including Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), and Sjogren’s Syndrome (SS). Evidence indicates disturbances of the circadian clock to demonstrate detrimental effects on …
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Somatic Mutations in Primary Sjögren’s Syndrome
… a complete understanding of the pathogenesis of autoimmune diseases continues to elude us. In this thesis, I explore the hypothesis that somatic mutations may underpin the development and progression of autoimmune disease, specifically primary Sjögren’s syndrome (PSS). PSS is a chronic, systemic …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
Systemic lupus erythematosus (SLE) is complex autoimmune disease in which autoantibodies form against double stranded DNA (dsDNA) and nuclear antigens. Autoantigen immune complexes form, deposit in the vasculature, and cause multisystem organ damage. Both genetic and environmental factors …
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