Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"autoimmune diabetes"”.
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Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is …
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Natural killer T cell subsets and regulation of autoimmune diabetes
… of pathogens, tumor rejection and regulation of autoimmune reactions. The broad spectrum of their activities suggested that functionally different subsets of NKT cells might exist. We have been able to demonstrate two functionally distinct splenic NKT cell populations identified by their surface …
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Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
Autoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. The much more prevalent …
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Exploring the Grey Zone between Type 1 and Type 2 Diabetes
… and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune …
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Epidemiology of diabetes in a well defined population in Sweden: the Skaraborg Diabetes Registry
… their ability to distinguish type 1 from type 2 diabetes, and factors associated with the prognosis of diabetes were explored. The incidence and the age at onset remained stable but the prevalence of diabetes increased due partly to improved survival, partly to changed criteria for diagnosis. At …
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Plant-delivered Cholera Toxin B subunit as an Immunomodulatory Molecule
… and rotavirus toxin-induced diarrhea and for autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM).</p> <p>Mice fed with transgenic potato tubers synthesizing 0.3% of CTB as total tuber protein generated serum and mucosal antibodies with toxin neutralizing capability. The …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
… and preventing disease in the experimental autoimmune encephalomyelitis model. However no halt or delay in onset of autoimmune diabetes was observed when insulin was targeted to DCs in the non-obese diabetic (NOD) mouse model. Also, foreign antigen-specific T cell responses could not be …
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Translating autoimmune genetic risk scores into improved prediction and classification of disease
… of established genetic risk for type 1 diabetes is hindered by a lack of standardisation and understanding of disease heterogeneity. This thesis aims to address these issues by utilising genetic risk scores (GRS) to enhance type 1 diabetes prediction, differential diagnosis, and …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… +]T cells are stimulated to cause autoimmune disease using a TCR transgenic mouse model of autoimmune type 1 diabetes (T1D). These mice harbor CD8[superscript +]T cells that express transgenic P14 TCR (P14 cells), which recognizes an antigenic peptide derived from the glycoprotein …