Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 725 for “"autoimmune"”.
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The Gelatinases and Autoimmune Disease
… the same ones that contribute to their role in autoimmune disease. While MMPs are best known for being dysregulated in chronic disease states, they also have the ability to contribute to disease onset. There are highly specific regulatory differences among MMPs. This is how the proper MMP is …
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Examining autoimmune sequelae during cancer immunotherapy in a combined autoimmune thyroiditis and tumor mouse model
… cancers have resulted in the development of autoimmune sequelae, including autoimmune thyroiditis. It has been suggested that the immunotherapy resulted in an alteration in the immunoregulatory mechanism(s). Using experimental autoimmune thyroiditis (EAT), a mouse model of Hashimoto's …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
Multiple Sclerosis (MS) is an autoimmune-mediated demyelinating and neurodegenerative disease of the central nervous system. Most MS patients experience a disease course characterized by periods of symptom exacerbation (relapses) followed by periods of partial recovery (remission). Relapse …
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The TREX1 3' Exonuclease and Autoimmune Disease: Structural and Biochemical Analysis of Disease Mutants Involved in Autoimmune Dysfunction
… Trex1 gene are the underlying cause of multiple autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), and retinal vasculopathy and cerebral leukodystrophy (RVCL). Several cellular roles have been proposed for TREX1 …
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Biologic therapy in patients with autoimmune arthritis /
… drugs (BD) have been used in the treatment of autoimmune arthritis (AA) for over 15 years. In spite of the many randomized clinical trials on BD, there is a lack of data on the special aspects of long-term application in everyday rheumatology clinical practice; for this reason the aim of our …
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… to be manipulated for therapeutic benefit in autoimmune and inflammatory disorders, such as neurodegenerative diseases.</p> <p>Foxp3-expressing regulatory T (Treg) cells are specialized immunosuppressive cells that establish immune tolerance to prevent the development of autoimmune and other …
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Autoimmune Susceptibility Imposed by Public TCRβ Chains
… TCR, those present in most individuals, modulate autoimmune risk. High resolution analyses of autoimmune encephalomyelitis-associated T-cell receptor β chain (TCRβ) showed preferential utilization of public TCR sequences, implicating them in pathogenesis. Disease-associated public TCRβ, when …
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Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is …
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Biomarker Discovery in Autoimmune Diseases: A Proteomics Approach
… profiling studies were performed on two autoimmune diseases. Protein profiles with high mass peak fidelity were obtained with high discriminatory power. Selective differential peaks were further investigated and confirmed to display differential levels in clinical samples. Validation in a …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… questions for the understanding and treatment of autoimmune diseases. Evidence implicates cell death and autoantigen modifications in the initiation of autoimmune reactions. One form of neutrophil cell death deserves attention because it occurs as a consequence of neutrophil activation, requires …
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
In studies on the pathophysiology of the autoimmune neuropathy, Miller Fisher syndrome (MFS), monoclonal antibodies to the disialosyl epitopes on GQ1b, GT1a and GD3 gangliosides have been produced. Antibodies to these complex gangliosides are thought to be crucial in the pathogenesis of MFS. These …
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Genetic Control of Experimentally Induced Reproductive Autoimmune Phenotypes
… phenotype while others may affect multiple autoimmune diseases. Sequencing of candidate genes for Aod2 and Aod5 showed polymorphisms between resistant and susceptible strains. Multiple congenic strains of mice encompassing Aod1 were constructed and demonstrated that Aod1 primarily influences …
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Hematopoietic Stem Cells and Progenitors in Murine Autoimmune Arthritis
… HSCs) and Progenitors, in a spontaneous murine autoimmune arthritis model. We found that these mice have a systemic increase in myeloid cells, which correlated with an increased frequency of granulocyte-monocyte progenitors relative to other committed progenitors in arthritic marrow. Gene …
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Association of autoimmune thyroid disease and type 1 diabetes
Overt autoimmune hyperthyroidism and hypothyroidism were found three times more commonly in insulin-dependent than in non-insulindependent diabetics. Similarly, clinically unrecognised primary autoim¬ mune thyroid failure, as evidenced by elevation of the serum thyrotro¬ phs concentration, was …
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Identifying a Target Protein and Ligands for Autoimmune Disorders
<p>Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by unprovoked inflammatory responses that lead to tissue degradation. Patients suffering from SLE display an overexpression of master regulatory protein HIF-1 HIF-1is a transcription factor for pro-inflammatory cytokine …
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central nervous system (CNS) that is more prevalent in genetically susceptible women compared to men. Alteration in the level of CysC in the CNS of MS patients …
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The modulation of autoimmune disease progression in mouse models
… roles in the development of the two human autoimmune diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are temporary and …
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