Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"autoantigens"”.
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AUTOANTIGENS IN PARKINSON'S DISEASE
… This thesis examines the role of two autoantigens, α-synuclein and the stress inducible phosphoprotein 1(STIP1) in PD. α-synuclein has been widely implicated in PD pathogenesis while STIP1’s role in PD remains to be determined. Here, we performed a detailed characterization of …
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Der Einfluß eines fötal exprimierten Autoantigens auf die Induktion von Autoimmunität während der Schwangerschaft
Ein Fötus exprimiert während der Schwangerschaft paternale Antigene, die für die Mutter fremd sind. Es wurde gezeigt, daß der Fötus eine spezifische, systemische Toleranz in der Mutter gegenüber diesen paternalen Antigenen induziert. Während der Schwangerschaft kommt es häufig zu Remissionen …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… protein antibodies (ACPA) to citrullinated autoantigens such as fibrinogen. Although RA pathogenesis has not been elucidated, genetic predisposition, environmental insults and viral pathogens are considered contributory factors. Human endogenous retrovirus K10 (HERV-K10) is one such virus as …
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THE ROLE OF THE MACROPHAGE IN ASBESTOS INDUCED AUTOANTIBODY PRODUCTION
… is generated through a two hit mechanism. First, autoantigens become visible to the immune system during apoptosis, which results in the accumulation of autoantigens on the cell surface. The subsequent uptake and processing of apoptotic cells by antigen-presenting cells in a pro-inflammatory …
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THE ROLE OF THE MACROPHAGE IN ASBESTOS INDUCED AUTOANTIBODY PRODUCTION
… is generated through a two hit mechanism. First, autoantigens become visible to the immune system during apoptosis, which results in the accumulation of autoantigens on the cell surface. The subsequent uptake and processing of apoptotic cells by antigen-presenting cells in a pro-inflammatory …
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Plant-delivered Cholera Toxin B subunit as an Immunomodulatory Molecule
… transgenic potato plants synthesizing the IDDM autoantigens, insulin and glutamic acid decarboxylase and their conjugate proteins with CTB. Transgenic potato plants synthesizing the fusion proteins significantly reduced pancreatic inflammation (insulitis) and clinical diabetes when fed to …
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Circulating Autoantibodies In Human Traumatic Spinal Cord Injury Subjects and Their Relationship to The Development of Neuropathic Pain
… has not been thoroughly characterized nor have autoantigens been identified. Glial fibrillary acidic protein (GFAP) and collapsin response mediator protein2 (CRMP2) were identified as candidate autoantigens. The hypothesis is that proteins from the injured spinal cord released by SCI trigger …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
… diseases such as T1D by mucosal delivery of autoantigens for immunotolerization have yielded only partial success. Attainment of satisfactory levels of sustained immunological tolerance remains to be accomplished. To restore self-tolerance requires delivery of sufficient amounts of …
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Untersuchung zur Spezifität von Autoantikörpern bei Patienten mit linearer IgA Dermatose
… Domäne des 180 kDa bullösen Pemphigoid-Autoantigens (BP180, Typ XVII Kollagen) dar. Die vorliegende Studie ging der Frage nach, ob LAD-Seren mit der immunodominanten Region von BP180 (NC16A Region) unmittelbar an der Zellmemran der basalen Keratinozyten reagieren. Diese Region ist das …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… factors that disrupt self-tolerance to myelin autoantigens but their identity and mode of action are unknown. This study reports that the epitope specificity of autoantibodies to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is heterogeneous and that …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… and, in particular, the specificity of target autoantigens was also evaluated in a lung transplant patients with either established grade 2-3 BOS (n=10), or without BOS (n=10). My work suggests that the presence of donor CD4 T cell chimerism in the peripheral blood of lung transplant recipients …
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An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers
… and 0.94, respectively. Furthermore, other top autoantigens, including COL6A1, THEG and CEACAM7, a homologue of CEACAM1, were also identified in this thesis by affinity purification-mass spectrometry (AP-MS) for patients from the same cohort, providing supporting evidence that these antigens are …
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Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
… of inflammation, the immune response to autoantigens and ultimately persistent tissue damage, and on the other - insufficient activation of the complement cascade leads to impaired clearance of immune complexes and apoptotic cells with their accumulation and development of autoimmunity. …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… a clear role for HERVs in RA pathogenesis, autoantigens implicated in disease pathogenesis were scanned for sequence homology to retroviral genes. Such epitopes would induce antibodies cross reactive with host proteins, resulting in disease. Short peptides mimicking these regions were …
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cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis
… could be greatly enhanced by linkage of β-cell autoantigens (Auto Ag) to adjuvant molecules such as the non-toxic cholera enterotoxin B subunit (CTB). To identify mechanisms responsible for CTB-autoantigen fusion protein suppression of diabetes autoimmunity, dendritic cells (DCs), a major class …
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Analysis of the Tumour Microenvironment in CLL
… of binding to these aberrantly expressed autoantigens. This study provides insights into the mechanisms that underpin the cytoprotection afforded by CLL cell-endothelial cell co-culture and identifies potential new targets for disrupting these signals in vivo.
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… can be used to identify autoantibodies and autoantigens that are targeted in SLE patients. Using this approach, we identified Stress Induced Phosphoprotein 1 (STIP1) as an autoantigen in a subset of SLE patients. Those patients with elevated levels of anti-STIP1 IgG autoantibodies in their …
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Engineering Secreted Proteins for Gene Transfer and DNA Vaccination
… potential of genes encoding engineered secreted autoantigens for the treatment of autoimmune disease using gene vaccination, human GAD65 was engineered to be secreted by mammalian cells. GAD65 is a major autoimmune antigen involved in the development of type I diabetes in both non-obese diabetic …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… activated neutrophils as the source of autoantigens. In addition, we identified and characterized deimination of linker histone H1 and found rare autoantibodies to deiminated H1 in SLE and Sjogren's syndrome patients. We also studied sera of autoimmune lupus prone mice to determine if …
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