Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"autoantigen"”.
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… to induce tolerance is to express the target autoantigen by DNA vaccination. In this work, the potential of vaccination with a DNA construct encoding the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in multiple sclerosis, to induce tolerance and protect against …
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Das Protein La/SS-B: Vom Autoantigen zur Zielstruktur für die Immuntherapie
Das La-Protein wurde als Autoantigen bei Autoimmunpatienten, die an SLE oder Sjögren-Syndrom erkrankt sind, entdeckt. Es kommt in phosphorylierter Form im Zellkern aller Eukaryonten vor und nimmt Aufgaben bei der Faltung, Prozessierung und nukleären Retention von RNA-Polymerase III-Transkripten …
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Ex vivo Charakterisierung von humanen Autoantigen-spezifischen CD4+ T-Zellen mit Fokus auf Multiple Sklerose
… nicht. Ein deutlicher, aber variabler Anteil der Autoantigen-spezifischen T-Zellen wies einen Memory-Phänotyp (CD45RO+) auf. Interes¬santerweise korrelierte der Anteil an autoreaktiven Memory-T Zellen in beiden Probandengruppen mit dem Anteil an CD4+ Memory T-Zellen innerhalb der Gesamt-T …
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cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis
… insulin. Later experiments showed that insulin autoantigen induced immune tolerance could be greatly enhanced by linkage of β-cell autoantigens (Auto Ag) to adjuvant molecules such as the non-toxic cholera enterotoxin B subunit (CTB). To identify mechanisms responsible for CTB-autoantigen …
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
… Tconv cell TCR repertoires were distinct, and autoantigen-specific Treg and Tconv cells were enriched in diseased tissue. Autoantigen sensitivity and fine specificity of these cells intersected, implying that differences in responsiveness were not responsible for lineage specification. Notably, …
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Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
… for lymphocyte activation in the context of the autoantigen is key to developing successful ASITs. Antigen-drug conjugates represent a novel class of therapeutics for the induction of immune tolerance designed to direct the effects of small molecule immunosuppressants through conjugation to the …
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Design of Novel Antigen-Specific Immunotherapies for the Treatment of Autoimmune Disorders
… to treatments in which a disease-causing autoantigen is known seek to leverage antigen specificity through the development of antigen-specific immunotherapies (ASIT). In this research, we explore different novel approaches to ASIT focused on chemical conjugation, including the design and …
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Autoimmune Susceptibility Imposed by Public TCRβ Chains
… could further endow unprimed T cells with autoantigen reactivity. Enforced expression of two of six public but no private TCRβ further provoked spontaneous, early-onset autoimmunity in mice. These findings implicate public TCR in skewing repertoire response characteristics and autoimmune …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
… diseases such as T1D by mucosal delivery of autoantigens for immunotolerization have yielded only partial success. Attainment of satisfactory levels of sustained immunological tolerance remains to be accomplished. To restore self-tolerance requires delivery of sufficient amounts of …
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Der Einfluß eines fötal exprimierten Autoantigens auf die Induktion von Autoimmunität während der Schwangerschaft
… Hypothese aufgestellt, daß die Expression von Autoantigenen durch den Fötus zu den beobachteten Remissionen beiträgt. Um diese Hypothese zu prüfen, sollte ein neues transgenes Mausmodell entwickelt werden. Als Autoimmunkrankheit wurde EAE (Experimentelle Autoimmune Enzephalomyelitis) als …
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Innate and humoral immune responses to HIV-1
… dysregulation, consistent with recognition of autoantigen/s by 4E10 and the presumption that tolerance mechanisms may hinder the elicitation of 4E10 or 4E10-equivalent responses. The previously proposed candidate 4E10 autoantigen was the mitochondrial lipid cardiolipin. However, using …
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Autoimmune Responses to Atherosclerotic Lipids: A Study In Murine Models of Atherosclerosis and Obesity
… were identified and characterized as potential autoantigen for CD1d-restricted T cells. Derived from phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine by oxidization, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) is v commonly found in atherosclerotic plaques. …
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CHARACTERIZATION OF CD4+ T CELL-INDUCING EPITOPES OF ISLETSPECIFIC GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT-RELATED PROTEIN (IGRP) THAT PREVENT AUTOIMMUNITY
… protein (IGRP) is an important β cell autoantigen recognized by a majority of cytotoxic CD8+ T cells. This study investigates two IGRP peptides (P3 and P7) which contain MHC class Il-specific CD4+ T cell epitopes. Amino acid residues critical for the activity of P3 and P7 were …
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Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
… (Tr1) cells and immuno-suppression of autoantigen-loaded antigen presenting cells (APCs) in an IL-10 and TGF-beta-dependent manner. We have established that suppression is disease- and organ-specific and effective in different autoimmune diseases (EAE and CIA) and genetic background …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… factors that disrupt self-tolerance to myelin autoantigens but their identity and mode of action are unknown. This study reports that the epitope specificity of autoantibodies to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is heterogeneous and that …
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Aspects of autoantibody epitopes in type 1 diabetes
… and affinity of ZnT8A are poorly understood. The autoantigenicity of the ZnT8 polymorphism is unique and comparable protein sequence variations are not found for insulin, GAD65 or IA-2. Neuropeptide Y (NPY) was reported as a minor autoantigen in T1D. This neurotransmitter has a SNP, rs16139, at aa …
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Expression von rekombinanten Antigenen zur Untersuchung der Autoantikörperspezifität bei Goodpasture-Syndrom
… von Immunkomplexen zu sehen. Das Goodpasture-Autoantigen ist Bestandteil eines speziellen Kollagennetzwerkes, das nur in der glomerulären und alveolaren Basalmembran vorkommt. Das Goodpasture-Autoantigen ist von diskontinuierlicher Struktur. Für die Antikörperbindung sind vor allem die …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
… class-switched plasmablasts that respond to autoantigen. CGS treatment of mice after the early onset of mild arthritis also had a therapeutic benefit and blocked disease progression. CGS therapy reduced the number pathogenic GC-Tfh cells and autoantibody titers, suggesting that A2aR …
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Nova Regulation of Alternative Splicing in the CNS
<p>Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder associated with gynecologic cancer and CNS motor dysfunction, is a neuronspecific nuclear RNA binding protein. The work presented here confirms that Nova-1 acts as a regulator of alternative splicing in vivo. …
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EpitopeAnalysisofCytokeratin 18Protein binding withAutoantibodiesin SeraofPatientswith NonallergicAsthma.
… 18 (CK18) protein was identified as an autoantigen associated with nonallergic asthma. In this study, epitope of CK18 protein binding with autoantibodies in sera of patients with nonallergic asthma was analyzed. METHODS: We used sera of 3 patients with nonallergic asthma who had …
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