Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"autoantibody"”.
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Autoantibody Responses to Traumatic Brain Injury
… following TBI, and uses this to investigate the autoantibody responses which occur after TBI, both during the acute phase and at long-term time points up to many years post-injury. Two distinct responses appear to occur contemporaneously: 1) a broad “polyantigenic” upregulation of antibody …
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Germinal centre autoantibody responses following heart transplantation
… murine model, I show that antinuclear autoantibody responses were initiated upon graft-versus-host allorecognition of recipient B cells by donor CD4 T cells transferred within the heart allograft. Rejected allografts displayed features of chronic humoral vascular rejection, with …
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Aspects of autoantibody epitopes in type 1 diabetes
… aim of this thesis was to investigate the autoantibody epitopes of ZnT8 and NPY in newly diagnosed T1D patients as well as in patients with long-term T1D and T2D. Our data in paper I and IV suggests that the polymorphic 325 variant is a major determinant of a conformation-dependent ZnT8A …
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In Vivo Identification of SLE1B: LY108 Mediates Autoantibody Production
… of murine lupus, Sle1b mediates anti-nuclear autoantibody (ANA) production. Our goal is to determine the causative gene in the Sle1b locus. Seven members of the SLAM/CD2 family are located within the Sle1b interval, and previous work has shown that structural and expression polymorphisms in …
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The evolution of the autoantibody response in Graves’ disease
Graves’ disease (GD) is an antibody-mediated autoimmune disease caused by thyroid stimulating antibodies (TSAbs) activating the thyrotropin receptor (TSHR). Both genetic and environmental factors contribute to pathogenesis and one such factor is the infectious agent, Yersinia enterocolitica. Two …
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Cytotoxicity and DNA cleaving activity of Anti-DNA Autoantibody
"항-DNA 자가항체는 전신성 홍반성 낭창(SLE)의 유발에서 중요한 역할을 수행한다. 하지만 이러한 항체의 자가 면역질환에서의 잠재적인 표적물질과 병리학적인 역할은 아직 명확히 규명되어 있지 않다. 본 연구의 목적은 첫 번째로 항-DNA 자가항체의 DNA-절단 활성과 암세포와 정상세포에서의 세포독성을 분석하고 두 번째로 항체에 의한 세포사멸이 apoptosis를 통해 일어나는지 또한 어떠한 메카니즘이 관여하는지를 밝히고자 하는 것이다. "
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An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers
… curve (AUC)-values were identified as potential autoantibody-based biomarkers. The top 10 antigen biomarker candidates include CEACAM 1, COL6A1, GRWD1, MAGEA1, MAGEA5, MAGEA10, NY-CO-1, SGY-1, SPANXB1 and THEG. Using these biomarker candidates, distinct clusters of healthy controls (HCs) and CRC …
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THE ROLE OF THE MACROPHAGE IN ASBESTOS INDUCED AUTOANTIBODY PRODUCTION
Environmental exposure to silicate compounds such as silica and asbestos has been associated with increased autoimmune responses and the development of autoimmune disease in humans. Residents of Libby, MT have experienced significant asbestos exposure due to an asbestos contaminated vermiculite …
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THE ROLE OF THE MACROPHAGE IN ASBESTOS INDUCED AUTOANTIBODY PRODUCTION
Environmental exposure to silicate compounds such as silica and asbestos has been associated with increased autoimmune responses and the development of autoimmune disease in humans. Residents of Libby, MT have experienced significant asbestos exposure due to an asbestos contaminated vermiculite …
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Probing the sensitivity of autoantibody production to B cell depletion by Rituximab
… used in patients with autoimmune disease, IgG autoantibody titres often fall whilst serum IgG anti-tetanus toxoid antibody titres are unaffected. Antibodies of both these antibody specificities have features associated with production by long-lived CD20- plasma cells that should be resistant to …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
… route from local thymic dysfunction to systemic autoantibody production. TCs illustrated a different but targetable immune state, in which TRM-like cells retained cytotoxic programs but co-expressed multiple inhibitory receptors such as PD1, TIM3, CD38 and CD39, supporting the investigation of …
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A COHORT STUDY INVESTIGATING AUTOANTIBODY LEVELS DURING AND AFTER INFECTION WITH INFLUENZA A VIRUS
<p>Antinuclear autoantibodies (ANAs) are present in all individuals. In those with autoimmune diseases they are routinely present in elevated levels. Although the nature and development of autoimmune diseases are not fully understood there are many hypotheses as to possible causes of an autoimmune …
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Development and characterization of recombinant human autoantibody using cDNA made from peripheral blood mononuclear cells of patients with bronchial asthma
국문요약 ⅰ 차례 ⅲ 그림차례 vi Ⅰ. 서론 1 Ⅱ. 재료 및 방법 3 A. 대상 환자의 선별 및 채혈 3 1. 대상 환자 및 비알레르기성 천식의 임상적인 중증도 분류 3 B. 비알레르기성 천식 환자들의 말초혈액으로부터 total RNA 추출 3 1. 말초혈액 단핵구 세포 (peripheral blood mononuclear cell, PBMC) 분리 3 2. Total RNA 추출 4 3. mRNA 분리 4 C. Polymerase chain reaction (PCR)을 이용한 cytokeratin 18 (CK-18) 단백질에 …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… antigens such as DNA and chromatin, resulting in autoantibody production, immune complex deposition, inflammation, and end organ damage such as glomerulonephritis (GN). Currently, only non-specific, immunosuppressive therapies are approved for use in lupus patients. These have undesirable side …
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A B-cell or a key player?: The role of the humoral immune response in melanoma, highlighting the importance of method development
… explored in relation to potential drivers of autoantibody production. The reactivity profiles of patients with metastasised melanoma prior to receiving treatment were then compared to healthy controls to determine baseline autoantibody characteristics. The effect of treatment on autoantibody …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
… involved in the generation of autoantibodies. An autoantibody is defined as "pathogenic" if it fulfills the Witebsky-Rose-Koch criteria for classical autoimmune diseases: definition of the autoantibody; induction of the disease by transfer of the autoantibody; and isolation of the autoantibody …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… of class-switched anti-nuclear effector autoantibody responses was dependent upon provision of help from donor CD4 T cells that were passengers within the graft. However, the fate of the donor passenger CD4 T cells in clinical organ transplantation is unclear. To assess whether a similar …
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Preeclampsia, Autoimmunity and The At1 Receptor
… the angiotensin II type 1 receptor activating autoantibody (AT1-AA). These autoantibodies act as angiotensin II and stimulate the ubiquitous AT1 receptor. To elucidate the role of AT1-AA in the pathophysiology of PE, a model of adoptive transfer was generated wherein AT1-AA isolated from human …
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