Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"autoantibodies"”.
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The optimisation of the enzyme linked immunosorbant assay (ELISA) for thyroid peroxidase autoantibodies (TPO) autoantibodies (aAbs)
… Assay (ELISA) for Thyroid Peroxidase (TPO)autoantibodies (aAbs) is a useful clinical test for diagnosing human thyroid conditions. In this study experiments were carried out in order to improve two aspects of the TPO ELISA produced by The Binding Site Ltd. Firstly, modifications were made …
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Identification and characterisation of cardiolipin autoantibodies
The aim of this study was to develop a method to isolate and identify anticardiolipin antibodies found in human serum samples obtained from patients with antiphospholipid syndrome (APS) APS is a disorder with clinical manifestations that include venous and arterial thromboembolism, …
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Modulatory effects of GluN1 autoantibodies on brain function
… high affinity to the GluN1 glycine-binding site. Autoantibodies to brain antigens including GluN1 are also commonly found in humans with neurological disorders and whether these antibodies could affect neuronal function is unclear. We generated epitope binding profiles for 14 human stroke sera …
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The identification of diagnostic serological autoantibodies for Cutaneous Melanoma
Abstract not available.
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Development of a Chemiluminescent Assay for Autoantibodies to Thyroid Peroxidase
The presence of antibodies to thyroid peroxidase (i.e. TPOAb) in human serum has been measured using an immunoradiometric assay (IRMA), an enzyme-immunometric assay, and three other immunoassay systems which incorporated the chemiluminescent label acridinium ester (AE).<br/><br/>The IRMA …
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Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.
… is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic factors (C3 NeF), cause partial C3 deficiency and are associated with increased susceptibility to bacterial infections. By analysis of samples from 20 patients …
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Structure-function and gene analysis of anti-DNA autoantibodies from BW mice
Anti-DNA autoantibodies in both autoimmune murine strains and in humans have been implicated in the pathogenesis of the autoimmune disorder SLE (systemic lupus erythematosus). The primary goal was to examine the structural features of monoclonal anti-DNA autoantibodies derived from the BW mouse …
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Specificity and structure-function analysis of lupus-derived monoclonal anti-DNA autoantibodies
… relationships of the monoclonal anti-DNA autoantibodies, BV 04-01 and BV 17-45, derived from the NZB/NZW F1 lupus-prone murine strain were examined. A single-chain Fv derivative of BV 04-01 was constructed and a series of site-specific mutants were engineered. A sensitive …
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Pathogenicity of autoantibodies to type VII collagen from patients with epidermolysis bullosa acquisita
Die Epidermolysis bullosa acquisita (EBA) ist eine subepidermal blasenbildende Autoimmundermatose, die mit Autoantikörpern gegen Typ VII Kollagen, den Hauptbestandteil der Verankerungsfibrillen der dermo-epidermalen Junktionszone (DEJ), assoziert ist. Bislang war jedoch unklar, ob diese …
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Autoantibodies From Patients With Nonallergic Asthma Cause Cytotoxic Injury To Airway Epithelial Cells.
RATIONALE: Increased levels of IgG autoantibodies to airway epithelial cells in serum samples of nonallergic asthma compared to allergic asthma and healthy controls have been reported. And a possible involvement of autoimmune response against bronchial epithelial cell antigen in the pathogenesis of …
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Characterization of Homogeneous and Heterogeneous Anti-Nucleic Acid Autoantibodies in Systemic Lupus Erythematosus
Three murine monoclonal anti-ssDNA autoantibodies were generated by fusion of spleen cells from autoimmune diseased NZB/NZW F1 hybrid mice with Sp 2/0-Ag 14 murine myeloma cell line. These monoclonal antibodies were purifed by affinity chromatography, and their immunochemical properties were …
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Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS)
… pathway (AP) of the complement system. Autoantibodies against factor H (anti-FHs), a regulator of the AP, were reported in 10% of patients, and are associated with the deficiency of factor H related 1 (FHR1), a FH homologous protein. <br></br><br></br> The aim of this thesis was to …
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NZB/NZW F1-Derived Monoclonal Anti-Dna Autoantibodies: Dual-Specificity and Immune Complex Formation
… of DNA, complement components and anti-DNA autoantibodies, with the primary pathogenic antibodies being dsDNA specific. Recent studies had identified a subpopulation of anti-DNA autoantibodies that possessed dual-specificity and appeared to form very avid immune complexes. The dual-specific …
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Circulating Autoantibodies In Human Traumatic Spinal Cord Injury Subjects and Their Relationship to The Development of Neuropathic Pain
… to NP. However, the relationship between autoantibodies and NP after SCI in humans has not been thoroughly characterized nor have autoantigens been identified. Glial fibrillary acidic protein (GFAP) and collapsin response mediator protein2 (CRMP2) were identified as candidate autoantigens. …
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