Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"auto-inhibition"”.
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Das Interaktom der SH2-Domänen der Proteintyrosinphosphatase SHP2 und ihren krankheitsrelevanten Mutanten
… entry of substrates can be prevented. Due to the auto-inhibition, and the variety of interactions with other proteins which also influence the activity of SHP2, its regulation is complex. Since little is known about the interaction partners of SHP2, this projects aims to identify novel interaction …
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Conditional Protein Alleles and Regulation of Bacterial Transcription: A Thesis in Two Acts
… phase growth, known as the group 1 σ family are autoregulated by a poorly understood mechanism. Group 1 σ factors are unable to bind to DNA in the absence of core RNA polymerase. The N-terminal domain of group 1 σ factors, known as region 1.1 is responsible for the auto-inhibition of DNA binding …
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The Intracellular Kinetics of HIV-1 Replication
… there are stages at which there is active viral auto-inhibition of the rate of replication. We therefore sought to characterize the timing of each major stage of the viral life cycle and to determine how they are correlated with one another. Using a variety of techniques including quantitative …
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Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… of the pestivirus genome. Npro is a cysteine auto-protease that cleaves between its own C-terminus (Cys168) and the N-terminus of the core protein (Ser169). Npro is essential for initiation of viral polyprotein processing and generation of a viable core protein for viral assembly. The …
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Mechanism of APC/C activation and substrate specificity in mitosis
… and biochemical analysis, we found that an auto-inhibitory segment of the Apc1 subunit acts as a molecular switch that in apo unphosphorylated APC/C interacts with a coactivator-binding site (C-box binding site), thereby obstructing engagement of Cdc20. Phosphorylation of the auto-inhibitory …
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Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… model captured growth rate dependent killing and auto-inhibition of meropenem and - also for vancomycin exposure - regrowth of the bacterial cultures due to adaptive resistance development. Stochastic interaction surface analysis demonstrated the pronounced antagonism between meropenem and …
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Understanding the activation mechanism of the Chk1 kinase
… of Chk1 function. They support a model of Chk1 auto-inhibition mediated by the intramolecular interaction of its kinase and regulatory domains, and of Chk1 enhanced activity promoted by interaction with its replisome partner Claspin.