Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"atypical hemolytic uremic syndrome"”.
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Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS)
Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy characterized by renal failure and determined by genetic and acquired defects of alternative pathway (AP) of the complement system. Autoantibodies against factor H (anti-FHs), a regulator of the AP, were reported …
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Investigation of Phosphatidylinositols and Phosphoinositides Using Matrix- Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
… are implicated in various diseases, including atypical hemolytic uremic syndrome (aHUS), necessitating a deeper understanding of their spatial distribution and abundance. Given the low concentration of PIs and PIPs, the study aimed to optimize MALDI-MSI for their detection. Thus, various …
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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
… been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional assays. The mutations are homozygous or compound heterozygous in patients with complete FI …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
… convertase leads to a secondary C3 deficiency. Atypical hemolytic uremic syndrome: aHUS) is a thrombotic microangiopathy that primarily affects the kidneys. This disease is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Heterozygous mutations in …
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Studies of EHEC and the complement system in renal diseases
… and clinical course of specific renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD). HUS may be associated with infection caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, …