Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 706 for “"atypical"”.
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Specific Recognition of Atypical Ubiquitin Modifications
… are well-described, the remaining, so-called atypical Ub chains have largely resisted characterisation. The broad aim of this thesis was to better our understanding of atypical Ub modifications with a focus on Ub recognition by linkage-specific binders. In the first part, the UBD family of …
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Interaction Mapping of the Atypical Protein Kinase WNK3
… light, and together with WNK1, they comprise an atypical branch of the kinome--the functions and significance of which are still being elucidated. Of clinical significance, WNKs 1 and 4 have been implicated in a heritable form of hypertension (pseudohypoaldosteronism type II). WNK3 has been …
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A comparative analysis of atypical and typical spelling abilities
The spelling abilities of older students with atypical spelling were compared to younger spelling-age matched students with typical spelling. The purpose was to determine if older students performed similarly to the younger students when spelling errors were analyzed according to four spelling …
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Characterization of an ethanologenic yeast inhibiting atypical galactose metabolism
In the near future, biomass-derived energy is predicted to substantially complement that generated from petroleum. However, certain types of biomass employed as substrates in the microorganism-mediated production of renewable fuelethanol contain significant amounts of the recalcitrant hexose sugar …
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Imitation of atypical biological motion in autism spectrum disorders
… with autism exhibited low-fidelity imitation of atypical biological motion. In Chapter Three it was observed that when selective-attention instructions were provided, although eye movements recorded during action- observation was similar to controls, imitation of atypical biological motion was …
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… PDGFRB, FGFR1 and JAK2. However the majority of atypical MPDs still remain to be characterised and identification of patients harbouring fusions, particularly those involving the PDGF receptors is of increasing importance, as they are likely to be responsive to targeted therapy with …
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Tibial bone properties and mechanics under atypical loading conditions
… to a stress fracture. The response of bone to atypical loading conditions has been less studied and can help identify conditions that may place bone at increased risk of stress fractures. Therefore, the aim of this thesis was to (1) evaluate impact strength following fatigue loading of bone, …
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Synthesis, biological activity and mechanism of atypical carotenoid antilipoperoxidants
… the antilipoperoxidant activity of three highly atypical carotenoids, peridinin, synechoxanthin, and chlamydaxanthin. We synthesized each of these natural products utilizing an efficient and modular building block based approach. This strategy allowed for initial activity assays as well synthesis …
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Investigation of an atypical protoporphyric family in South Africa
… of this family revealed features that were atypical of erythropoietic protoporphyria. These included a highly penetrant disease, disease severity as expressed by more prevalent hepatic complications, a preponderance of protoporphyrin in its zinc chelated form, a therapeutic response to iron …
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
… of TGFβ signalling pathways and found that the Atypical PKC isoforms (aPKC; a subgroup of the PKC family) indeed can alter TGFβ receptor signaling. My work has shown that the modulation of aPKC expression or activity using inhibitors and/or small interfering RNA (siRNA) prolongs the temporal …
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DEFYING CONVENTION: ATYPICAL PERSPECTIVES OF SLAVERY IN ANTEBELLUM NEW ORLEANS
<p>During the first half of the nineteenth century, slavery became a vital economic component upon which the success of the southern states in America rested. Cotton was king, and slavery was the peculiar institution that ensured its dominance in the domestic and international markets of America. …
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Atypical workers: the quest for an inclusive workers protection regime
… a continuous evolution. The growth of · atypical or non-standard forms of employment is one such phenomenon. Regrettably, the juridical discipline does not always follow the dynamics of the development of socio-economic phenomena. Very often, new social phenomena are governed by old …
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Biological Consequences of Atypical Phage Conversion in Gram-Positive Pathogens
… phage-bacteria interactions, describing atypical mechanisms ("conversion events") by which phage shape the populations of Bacillus anthracis and Staphylococcus aureus, driving their increased diversity and likely impacting their natural behaviors. In B. anthracis, phage contributions to …
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Private Speech and Inner Speech in Typical and Atypical Development
… studies investigating the SDS of two groups of atypically developing children who show risk factors for SDS impairment—those with autism and those with specific language impairment. The research reported in Chapter 5 tests an important tenet of neoVygotskian theory—that the development of SDS …
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The role of blood-borne factors in triggering atypical astrocytes
… changes in astrocytic protein expression as an "atypical astrocyte response." Yet, the upstream mechanisms that induce this atypical astrocyte response after mTBI have yet to be elucidated. In models of more severe TBI, exposure to blood-borne factors triggers astrogliosis via upregulation in …
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