Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"atypia"”.
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Ipsilateral and concurrent breast cancer and atypical ductal hyperplasia: Does atypia also need surgical excision?
… not affected by the size of the cancer, size of atypia, or distance between the ipsilateral malignancy and atypia. This suggests that omission of surgical excision for ADH in patients with concurrent breast cancer may be appropriate, like those with isolated ADH, when a select low risk subset …
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How Diet Influences Breast Cancer Risk: Analysis of Tissue Fat, Nutrients, and a Dietary Pattern among High-Risk Women
… breast tissue analyzed for evidence of cytologic atypia, which is a biomarker for short-term risk of breast cancer development. The fatty acid composition of several lipid compartments of their blood and breast tissue was analyzed by gas chromatography. Their nutrient and food consumption was …
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Morphological and Immunocytochemical Investigation of Canine Oligodendrogliomas
… histomorphologic features (mitoses, cellular atypia, necrosis, vascular hypertrophy, and vascular proliferation), and three immunocytochemical markers (GFAP, EGFR, and Ki-67 labeling index) and the degree of malignancy, as defined by WHO grading criteria, of 15 canine oligodendroglial tumors. …
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Deep Learning in Oesophageal Cancer Development: Integrating Multi-Stain Histopathology Images of the Capsule Sponge
… clinically relevant cases are not missed. The atypia model, however, performed poorly. Finally, Shiv Sakthivel and I developed an interpretable algorithm that detects atypia based on glandular and nuclear features already used in pathology practice. Together, these methods establish a scalable, …
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Predicting risk of malignancy in patients with indeterminate thyroid nodules
… FLUS nodules due to AUS nodules having nuclear atypia and FLUS nodules having architectural atypia.
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Early diagnosis of cancer using light scattering spectroscopy
… structures, such as cell nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs, …
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The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma
… (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, …
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Genetic and Molecular Studies of Endometrial Cancer
… endometrial carcinomas with prominent nuclear atypia, DNA damage, and aneuploidy, resembling human type II tumors. These studies thus lend support to the hypothesis that dysfunctional telomeres play a critical role in type II endometrial carcinogenesis.
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International Academy of Cytology Yokohama System for reporting Breast Fine Needle Aspiration Biopsy (FNAB) cytology: A Retrospective Study in a Single South African Tertiary Institution
… insufficient (9.09%), benign (4.46%), atypia (45.28%), suspicious for malignancy (72.5%) and malignant (91,09%). Conclusion: Breast aspiration cytology performed at GSH has shown good correlation with histopathology as well a high sensitivity and specificity comparable to international …
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Expression of E-cadherin and HGF in Hypopharyngeal Cancer
… degrees of mucosal changes and cellular atypia occur over large areas of epithelium. Hypopharyngeal squamous cell carcinoma(SCC) is well known as a aggressive cancer which has relatively poor prognosis. E-cadherin is a large family of Calcium dependent intercelluar Adhesion Molecule(CAM) …
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Deep learning on whole-slide images for early detection and risk prediction of oesophageal cancer
… two features prognostic of progression to EAC: atypia, a kind of cellular irregularity, and P53 aberrance. These models automate patient stratification and drastically reduce the time it takes to screen for these progression markers. I have also identified a clinically relevant correlation …
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
… we saw an increase in adenomas with atypia and adenocarcinomas in 3B-1 irradiated mice but not in 3B-2 and H irradiated mice. We also found that a non-toxic anti-inflammatory, anti-oxidative radioprotector (CDDO-EA) reduced 3B-1 induced oxidative stress and cancer initiation almost …
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Role of Sox9 In Uterine Gland Development and Disease Initiation
… presence of simple and complex hyperplasia with atypia, metaplasia, thick-walled blood vessels, and stromal fibrosis; all “hallmarks” that indicate overexpressing Sox9 leads to development of a polyp-like morphology. Therefore, we can propose the use of Sox9-cOE mice to study development of …
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Molecular Studies on Pathogenesis, Prognostic Factors, and New Treatment Options for Ovarian Granulosa Cell Tumors
… with higher tumor stage (II-III) and nuclear atypia. These results suggest that GATA4 can be used as a new prognostic marker for GCT. Human Epidermal Growth Factor Receptor 2 (HER2) is a known oncogene and a target for treatment in breast and gastric cancer. We found that high expression of …
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Συμβολή εις την μελέτην των χορδωμάτων
… cells in cases did not show either significant atypia or mitotic activity. The histologic picture of one case which gave metastases was similar with the histologic picture of the other cases which did not give metastases. 5. The sacrococcygeal chordomas were larger than the chordomas of the …
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Stem cells and neoplasia a study of acquired melanocytic naevi
… passes through defined stages of increasing atypia due to the accumulation of mutational events. The newly proposed tumour stem cell hypothesis, however, advocates melanoma may arise from a mutated tissue-resident precursor cell, and not froma terminally differentiated melanocyte. The overall …
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Tumour suppression mediated through DPC4, p53 and APC
… foci were characterised by morphological nuclear atypia. These studies suggest functional co- operation between TGF -(3 and Wnt signalling pathways in the suppression of pancreatic tumourigenesis in the mouse. In order to investigate TGF -ß signalling in WT murine primary pancreatic acinar cells …
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Enhancing Early Detection of Oesophageal Squamous Cell Carcinoma Through Shallow Whole-Genome Sequencing and Non-Endoscopic Sponge Sampling
… haematoxylin & eosin (H&E) staining for atypia detection and p53 immunohistochemistry (IHC). For the first time, I demonstrated the feasibility of detecting CNAs indicative of OSD and early cancer from non-micro-dissected, pan-oesophageal Cytosponge samples. My novel genomic approach …