Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"atropisomers"”.
-
SYNTHESIS OF PHARMACOLOGICALLY ACTIVE MOLECULES THROUGH BIOCATALYTIC APPROACHES: STUDY OF THEIR STEREOCHEMISTRY AND POLYMORPHISM BY MEANS OF SPECTROSCOPIC AND CRYSTALLOGRAPHIC METHODS.
… this drug exists in solution as a mixture of two atropisomers, which belong to class 2 due to an estimated interconversion rotational barrier of 22.3 kcal/mol. This finding could help to face the great challenges in the drug discovery and development of this class of compounds, caused by the …
-
Environmental biotransformation of chiral polychlorinated biphenyls and their metabolites
… for the different environmental fate of PCB atropisomers. Other affecting factors, such as presence of nanoparticles and changes in feeding ecology of organisms, also affect the fate of chiral contaminants. In vitro incubations of rat cytochrome P-450 2B1 (CYP2B1) isozyme with chiral PCBs …
-
Conformation and Stereodynamic of Hindered Aromatic System
… second chapter, the structures of axially chiral atropisomers of hindered biphenyl carbinols are studied. In the third chapter, the steric barriers and the -barrier of 1,8-di-aylbiphenylenes are determined. Interesting atropisomers are found in the cases of arylanthrones, arylanthraquinones and …
-
Sintesi e coordinazione di leganti Ciclopentadienilici O-Multifunzionalizzati
… in driving the equilibrium between the observed atropisomers 1a and 1b, by varying the planar chirality on the two π-complexes.
-
Control of selectivity in palladium-catalysed cross-coupling reactions using a sulfonated phosphine ligand
… coupling: desymmetrisation, and formation of atropisomers. Desymmetrisation was investigated on protected benzyhydrylamines resulting in good to excellent enantioselectivities being observed. The formation of atropisomeric biaryls was investigated with a wide range of coupling partners, with …
-
Efficient & Novel Approaches to Relay Chirality in the Synthesis of Planar Chiral Metallocenes
… were observed which could be conformational atropisomers arising from hindered rotation between two interacting aromatics as a result of conformational flexibility inherent of the lactone architecture e.g. (P,aR), (R,aS), (M,aR), (M,aS). With respect to the 5,5–membered cyclic ether complex …
-
Molecularly Imprinted Polymers--New Insights and Strategies
<p>Solvent programmable polymers (SPPs) were developed based on restricted rotation with the ability to respond and remember the stimuli-induced properties. The SPP was prepared via Ring Opening Metathesis Polymerization (ROMP). The recognition properties of SPPs can be modulated by heating in …