Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"atrial myocytes"”.
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The electrophysiological effects of Endothelin-1 in human atrial myocytes
… is associated with an increased incidence of atrial fibrillation (AF) and elevated levels of catecholamines and endothelin-1 (ET-1), each of which affects the atrial L-type calcium current (ICaL) and consequently action potentials. Hypotheses: ET-1 modulates the effects of isoproterenol (ISO) …
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Effects of relaxin on the electrophysiological properties of isolated atrial myocytes
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… are important sources of ROS in cardiomyocytes. Blocking NOX with apocynin or mitochondrial complex I with rotenone both completely suppressed ET-1-induced ROS generation and activation of ICl,swell, indicating that ROS from both NOX and mitochondria were required to activate ICl,swell, …
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Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
… to modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were inhibited by AS-$\rm\beta\sb{all}.$ These results support the idea that atrial T-type calcium channel is encoded by a member of the $\rm\alpha\sb{1E}$ calcium channel genes and is …
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Modulation of calcium channel expression in cardiac myocytes of rats during growth hormone-induced growth or normal postnatal development
Voltage-dependent Ca$\sp{2+}$ currents of cardiac myocytes were studied using patch-clamp techniques. T-type Ca$\sp{2+}$ current density of atrial myocytes was found to be positively correlated with the plasma growth hormone levels and the growth rate of atrial myocytes in normally developing …
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The Ultrastructural and Abnormal Calcium Handling in Pulmonary Vein Sleeve Cells, Atrial and Ventricular Myocytes During Ageing
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with age being a significant risk factor. It is well established now that electric activities originating from pulmonary vein sleeve cells (PVCs) initiate AF. Factors that are involved in maintaining AF include structural …
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Expression and Characterization of Calcium Channel Alpha1 Subunits in Atrial Tissue
… associated with growth and nuclear division. In atrial tissue, the LVA calcium current demonstrates developmental regulation and is upregulated in response to Growth Hormone (GH) and insulin-like growth factor I (IGF-1). It is unknown the alpha1 subunits responsible for producing the LVA current. …
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Molecular Characterization of the Regulatory Subunits of Voltage -Dependent Calcium Channels From Rat Heart
… level is upregulated upon IGF-1 stimulation in atrial myocytes, where IGF-1 also enhances LVA Ca2+ current density. Thus, the expression of cardiac LVA current stimulated by IGF-1 is probably regulated by the expression of alpha2delta-3. Multiple beta subunits and their splice variants are …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
… subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium currents regulate rhythmic activity and cell proliferation in the heart. Previous studies using heterologous expression systems showed that gamma6 …
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Molecular Interactions and Physiological Function of the Voltage-Dependent Calcium Channel Gamma6 Subunit
… of gamma6 and Cav3.1 in both HEK cells and atrial myocytes, and that the functionally critical domain and motif of gamma6 are not required for gamma6 interaction with Cav3.1. Furthermore, I describe the use of cell surface membrane protein biotinylation, purification, and quantitative …
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The role of intracellular Ca2+ in the arrhythmogenic activity of pulmonary vein cardiomyocytes
… of ectopic electrical activity that can cause atrial fibrillation. While the ectopic activity likely originates in the cardiomyocytes that form an external sleeve around the veins, the underlying mechanisms are unknown. Changes in intracellular Ca2+ signalling have been proposed to play an …
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The electrophysiological and molecular effects of chronic beta-adrenoceptor antagonist therapy on human atrium
… is associated with prolongation of the atrial cell action potential duration (APD), potentially contributing to the ability of these drugs to prevent atrial fibrillation (AF). The mechanisms underlying this APD prolongation are not fully understood but may involve pharmacological …
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The Role of the TBX5-driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with many well-known risk factors. Within the past decade, there has been a plethora of evidence to suggest that genetic factors also play an important role in the genesis of the arrhythmia, including the T-box …