Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"atorvastatin"”.
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The Effects of Weight Gain and Atorvastatin Treatment on Arterial Stiffness
… arterial stiffness in nonobese young males, and atorvastatin treatment reduces large artery stiffness in overweight and obese middle-aged and older adults. Consistent with our first hypothesis, weight gain increased arterial stiffness in nonobese young men. In addition, we demonstrated that, …
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Analysis of the effect of atorvastatin on the virulence of Fungal Pathogens
… virulence of a range of human fungal pathogens. Atorvastatin is a member of the statin drug family which are the main therapeutic agents used to decrease high serum cholesterol levels by inhibiting HMG-CoA reductase enzyme. HMG-CoA is an enzyme that is responsible for the production of farnesyl …
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Einfluß des HMG-CoA-Reduktase-Inhibitors Atorvastatin auf die chronische Transplantatniereninsuffizienz der Ratte
… des Hydroxy-Methylglutharyl-Coenzym-A-Inhibitors Atorvastatin nach Nierentransplantation bei Ratten(Fisher344/Lewis); Vergleich von drei Versuchsgruppen-jeweils acht Versuchstiere-bezüglich Gewicht, Diuresevolumen, Serum-Kreatinin, Serum-Harnstoff, Kreatinin-Clearance und Proteinurie nach 30, 60, …
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Effect of atorvastatin on asthma control and airway inflammation: a randomised controlled trial
… study was designed to test the hypothesis that atorvastatin improves asthma control and airway inflammation in adults with asthma. Methods Fifty four adults with allergic asthma were recruited to a 22-week crossover randomised controlled trial comparing the effect on asthma control and airway …
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Einfluss von Vitamin C und Atorvastatin auf die hämodynamische Wirkung von Isosorbid-5-mononitrat
… Vorbehandlung mit Antioxidantien (Vitamin C, Atorvastatin) auf die hämodynamische Wirksamkeit und Pharmakokinetik einer Einzeldosis von 80 mg IS-5-MN untersucht werden. <br> <br>Nach einer fünftägigen Vorbehandlung mit Vitamin C (3 x 500 mg/d), Atorvastatin (1 x 20 mg/d) oder Placebo wurde am …
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Einfluss der HMG-CoA-Reduktase-Inhibitoren Atorvastatin und Lovastatin auf die Regulation der Hepatischen Lipase
… dass die HL in vitro posttranslationell durch Atorvastatin bzw. Lovastatin reguliert wird. Dies geschieht durch die statininduzierte Aktivierung des Proteasoms, für das das HL-Protein als Substrat zu dienen scheint. Die Kompetition mit einem Hemmer des Proteasoms, MG-132, hebt den vorzeitigen …
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The Effects of Aqueous Atorvastatin on Steroidogenesis of <i>Xenopus laevis</i> at Environmentally Relevant Concentrations
… of mevalonic acid in the mevalonate pathway. Atorvastatin (Lipitor) is one of the most widely prescribed statin drugs and contamination of wastewater effluent is a growing environmental concern because of the potential to interfere with steroidogenesis in wildlife. Amphibians may be …
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Cardiovascular risk reduction in insulin resistant states
… controlled study on the pleotrophic effect of atorvastatin in patients with PCOS. Subsequent metformin therapy after atorvastatin treatment was undertaken. This study led to the investigation of the effect of simvastatin and atorvastatin on biological variation of lipids in patients with T2DM …
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Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
[color illustrations] We introduce a new class of bench-stable N-heterocyclic carbene nickel precatalysts for homogeneous nickel-catalysis. The nickel(II) complexes are readily activated to Ni⁰ in situ under mild conditions, via a proposed Heck-type mechanism. The precatalysts are able to …
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Der Einfluß von Atorvastatin auf die Serumlipide und den Aktivierungsstatus von Thrombozyten, Monozyten und Granulozyten bei Patienten mit Hyperlipoproteinämie; Typ IIa nach Frederickson
… Patienten erhielten für eine Dauer von 12 Wochen Atorvastatin 40 mg (Sortis®, Pfizer) bzw. Placebo. Um die Existenz pleiotroper Mechanismen nachzuweisen, untersuchten wir mit Hilfe durchflußzytometrischer Analysen am FACSCalibur® Veränderungen der Expression von Adhäsionsmolekülen auf der …
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Biomarkers and cell phenotypes in TB patients with minimal or persisting lung inflammation post-anti-TB treatment and ex-vivo atorvastatin immunomodulatory effects on M. tuberculosis-infected PBMC
… treatment to assess the safety and efficacy of atorvastatin in reducing post TB lung inflammation. At the end of TB treatment, Mtb culture-negative participants were stratified into minimal (Arm A, Total Lung Glycolysis (TLG) < 50 SUV) or persisting (Arm B/C, TLG ≥ 50 SUV) lung inflammation …
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IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
… broth dilution assays. Simvastatin, pravastatin atorvastatin, and rousuvastatin were used in this study. The minimum inhibitory concentration was considered to be the lowest concentration of statin that prevented bacterial growth, i.e. a clear test tube. Experiments were repeated twice for each …
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Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts
… enzyme. Fibroblasts were preincubated with atorvastatin or simvastatin for 24 hours in serum-free medium, and then incubated without a stimulus or with IL-1β for 6 days. OPG or RANKL in culture supernatants was measured by specific ELISA. Data were analyzed using ANOVA and Scheffe’s F …
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Statin-induced muscle mitochondrial toxicity
… clinical trial of high-dose simvastatin or atorvastatin versus placebo. Forty-eight hypercholesterolemic subjects were randomly assigned to receive placebo (N=16), high dose atorvastatin 40mg/day (N=16), or high dose simvastatin 80mg/day (N=16) for 8 weeks. Muscle mtDNA content was assessed …
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Analysis of patient drug usage trends in the POYC scheme
… valsartan (53), metformin (43), omeprazole (43), atorvastatin (34), bendroflumethiazide (32), and salbutamol (30). There has been an increase in the usage for 8 out of 10 drugs. The greatest rise observed was of atorvastatin, with 2,856 tablets dispensed in 2019 from 1232 dispensed tablets in …
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Cost-effectiveness analysis of alternative statin prescribing strategies for the secondary prevention of cardiovascular disease at a South African public sector tertiary hospital
… LDL-C concentration of <1.8 mmol/L; prescribing atorvastatin 80 mg without LDL-C monitoring; and the status quo, simvastatin 20 mg without LDL-C monitoring. I constructed a Markov model with annual cycles; a five-year timeline; starting age of 60 years; and the following health states: ≤1 year …
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Farmacijos specialistų žinios ir požiūris į gydymo statinais naudą ir jų sukeliamą nepageidaujamą poveikį /
… wort, less information had about interactions of atorvastatin with warfarin, and atorvastatin with macrolide group antibiotics, at least information had about amlodipine with simvastatin interaction. 3. Pharmacy specialists most commonly inform patients about the positive and negative effects of …
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The Multicomponent Synthesis of Pyrroles from Cylcopropane S Using a One Pot Pd(0) Catalyzed Dehydrocarbonylation Protocol
… into either BM 212 an anti-tuberculosis drug or Atorvastatin Calcium an anti-cholesterol drug. Each pharmaceutical will be derived using a three component coupling reaction and then conversion to a pyrrole followed by manipulations of the resulting functional groups.
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Earlier Detection of Antiphospholipid Syndrome
… of aortic stenosis. He was taking Valsartan, Atorvastatin, B-12, Folic Acid, and Vitamin D-3 before the episode. He was prescribed Xarelto after the episode. It was found that he had an optical stroke. Since the pressure in the eye was relieved, partial eyesight returned. He now has full …
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