Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"atopic dermatitis (AD)"”.
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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the disease has increased by two to three-fold in industrialized countries, with higher incidences in …
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ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS
Atopic dermatitis (AD) is a common inflammatory skin disease, which is characterized by skin barrier defect and immune dysregulation. In this study, we investigated the role of microRNA in AD pathogenesis. We found miR-335 to be highly expressed in the differentiating layers of normal epidermis but …
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Determinants of systemic treatment response in atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense pruritus and recurrent eczema. Its heterogeneous pathophysiology involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted …
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Ex-vivo Untersuchungen zur Arzneimittelwirkung topischer Tacrolimus (FK-506) Anwendung auf epidermale dendritische Zellen in läsionaler Haut bei Patienten mit atopischem Ekzem
Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which antigen-presenting epidermal dendritic cells (DCs), ie, …
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Environmental factors associated with atopic dermatitis in children in urban and rural South Africa
… contribute to the high prevalence of childhood atopic dermatitis (AD). Objectives: To identify environmental exposures associated with AD in children living in three residential areas of South Africa. Methods: A total of 3144 children aged 3 to 11 years participated in 1999 in a cross-sectional …
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… a healthy skin barrier by replenishing dead keratinocytes lost during daily turnover, injury, or pathological disturbances. In atopic dermatitis (AD) and psoriasis (PS), there is marked psoriasiform hyperplasia of the epidermis, suggesting a hyperproliferation of keratinocytes and …
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The prevalence and patterns of IgE-mediated food allergy and sensitisation in South African children with atopic dermatitis
… risk of food allergy such as children with atopic dermatitis (AD). This study aimed to determine the prevalence of, patterns and risk factors for, IgE-mediated food allergy in South African children with moderate to severe AD. It is the first food allergy prevalence study in South Africa to …
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Skin barrier dysfunction in common genetic disorders
… Europe have shown that null mutations in FLG lead to the loss of the filaggrin protein; this is the underlying genetic cause of ichthyosis vulgaris (IV) and is a significant predisposing factor for atopic dermatitis (AD) and other atopic conditions such as asthma, allergic rhinitis and food …
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A systematic review of treatments for atopic dermatitis
Atopic dermatitis is a very common inflammatory skin disease, particularly in children. A systematic review of randomised controlled trials of treatments for atopic dermatitis (AD) was carried out to assess how many trials exist, what they cover, what they do not cover, the research gaps, provide a …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposition factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the disease. …
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Bacteriome interactions in pediatric atopic dermatitis in a rural and urban South African cohort
… bacterial dysbiosis is common in children with atopic dermatitis (AD). However, there is limited data of these bacterial changes in sub-Saharan children with AD. Therefore, this study investigated the bacterial alterations in skin and nasal bacterial communities in AD compared to healthy …
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Staphylococci of the Skin: Consequences for Host Health
… host to inflammatory skin diseases. On healthy adults with an intact skin barrier, the skin microbiome is relatively diverse and stable. When the skin barrier is disrupted – either by daily stressors or genetic factors – the composition of the microbiome abruptly shifts to a less diverse state …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… from itchy skin. Among participants affected by atopic dermatitis (AD, 6%), a relapse-remitting, inflammatory skin disease, 96.8% complained about chronic itch, making it a hallmark symptom. Some forms of itch (e.g., histaminergic, resulting from an insect bite) are well-understood and treatable, …
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건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… AMPs, and vitamin D receptor (VDR) compared with atopic dermatitis and healthy control and whether an association exists between the serum 25(OH)D concentration and the TLRs, AMPs, and VDR expression of skin sample of psoriasis. Materials and Methods: From January 2008 to June 2008, a total of 12 …
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Improving the self-management of atopic dermatitis: the efficacy of a pictorial patient education tool
Background: Atopic dermatitis (AD) is a chronic relapsing skin condition that requires persistent self-management. Patient education is a key component in the self-management of many chronic diseases as it facilitates disease understanding and patient empowerment. Objective: The purpose of this …
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Improving the skin barrier function in atopic dermatitis
Atopic dermatitis, AD (synonym eczema) is a chronic inflammatory skin disease. It affects between 10 to 20% of children and 1 to 3% of adults worldwide. It is an important cause of morbidity and is estimated to cost £465 million per annum to the UK. AD is part of a family of Th-2 driven diseases …
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Investigating the effect of Staphylococcus epidermidis on the growth dynamics of Staphylococcus aureus in atopic dermatitis
Background: In atopic dermatitis (AD), studies have demonstrated inconsistencies in the interactions between Staphylococcus epidermidis and Staphylococcus aureus concerning growth and biofilm formation outcomes. This suggests that there might be a strain-level role played by the bacteria that …
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Investigating the effect of Staphylococcus epidermidis on the growth dynamics of Staphylococcus aureus in atopic dermatitis
Background: In atopic dermatitis (AD), studies have demonstrated inconsistencies in the interactions between Staphylococcus epidermidis and Staphylococcus aureus concerning growth and biofilm formation outcomes. This suggests that there might be a strain-level role played by the bacteria that …
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Molecular Mechanisms of Itch Sensations
… itch happens in various skin diseases such as atopic dermatitis: AD) and psoriasis. Chronic itch usually continues for over six weeks and is resistant to commonly used anti-histamine drugs. While pain has caught an early attention due to its severity, the molecular mechanism of itch has not …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… known as allergens. Both allergic asthma and atopic dermatitis (AD) are said to be induced by elevated levels of immunoglobulin E (IgE) and T helper 2 (Th2) immune cells and inflammatory associated cells such as eosinophils, mast, and basophils. Globally, asthma is affecting more than 300 …
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