Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"atherosclerotic plaques"”.
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Fibre Microstructure and Mechanics of Atherosclerotic Plaques
… in the mechanics and rupture risk of atherosclerotic plaques. Fibre structures in human atherosclerotic plaques were characterised through scanning electron microscopy, histology, and image processing. Local primary fibre orientation and the fibre dispersion were calculated. Plaque …
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Estimation of nonlinear mechanical properties of atherosclerotic plaques
… to estimate the mechanical properties of atherosclerotic plaques by combining genetic algorithm with finite element methods. Plaque images derived from optical coherence tomography were employed to construct finite element models which were subsequently used in conjunction with a genetic …
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Ultrasonic Characterization of Human Coronary Arteries and Atherosclerotic Plaques
… ultrasound interacts with arterial tissue and plaques may provide benefit to patients with coronary artery disease. The two-fold goal of the studies presented in this thesis was to better understand the fundamental physics of the relationship between ultrasound and coronary artery tissue and to …
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Development of multimodal spectroscopy for the detection of vulnerable atherosclerotic plaques
… information useful in detecting vulnerable atherosclerotic plaques, that is, plaques most prone to rupture and causing sudden death. Early detection of these vulnerable plaques is critical to reducing patient mortality associated with cardiovascular disease. In developing MMS into a clinical …
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Investigation Into The Role Of Biomechanical Forces In Determining The Behaviour of Coronary Atherosclerotic Plaques
… histological work has demonstrated that ruptured plaques are associated with higher stress compared to non-ruptured controls, with in vivo VH-IVUS studies linking higher plaque structural stress (PSS) with the presentation of acute coronary syndrome. Wall shear stress (WSS) on the other hand has …
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Biomechanical Analysis of Human Coronary Atherosclerotic Plaques in Response to Pharmacotherapy, and in Predicting Adverse Clinical Events
… histological work has demonstrated that ruptured plaques are associated with higher stress, with in vivo intravascular studies linking higher plaque structural stress (PSS) with the presentation of acute coronary syndrome. Endothelial shear stress (ESS) on the other hand has been implicated in …
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Application of magnetic resonance elastography to atherosclerosis
… of MRE to image the mechanical properties of atherosclerotic plaques. The cardiac cycle, lumen boundary, size and inhomogeneous nature of atherosclerotic plaques pose additional complications compared to more well-established MRE applications. Computational modelling allowed these …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either legumain or MMP-2/9 were synthesized. This was achieved via a combination of both solid and solution phase …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
… smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and display phenotypic plasticity that influences both plaque growth and stability. The fibrous cap, a stabilising feature of plaques, contains an abundance of VSMC-derived cells. However, the cellular transitions and …
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Elastography using optical coherence tomography : development and validation of a novel technique
… studies have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid-rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex vivo plaque geometry have found that most plaques rupture at sites of high circumferential …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… was not affected prior to the development of atherosclerotic plaques. Developed human carotid atherosclerotic plaques were dissected into defined regions including healthy media, shoulder region, fibrous cap and core and their respiration was investigated. The respiratory reserve capacity …
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Magnetic Resonance Imaging of Atherosclerosis
… strokes resulting from underlying carotid atherosclerotic disease. The clinical management of carotid artery disease relies primarily on the evaluation of the severity of carotid artery luminal stenosis. However, there is growing evidence that morphological and functional information about …
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Centrinių ir periferinių arterijų struktūrinių ir funkcinių pakitimų ypatumai sergant metaboliniu sindromu /
… mass index were found. However, higher number of atherosclerotic plaques in carotid artery was found only in females. Risk of cardiovascular disorders in males and females with metabolic syndrome is different. Nor in males, neither in females metabolic syndrome had no direct influence on pulse …
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Intravascular Optical Coherence Tomography Image Analysis
… and sudden deaths are due to the rupture of atherosclerotic plaques inside the arteries. Intravascular Optical Coherence Tomography (IVOCT), a high resolution (10-20µm) imaging modality that performs cross-sectional imaging of coronary arteries by measuring echoes of backscattered light, is …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
… in injury-induced neointimal lesions and in atherosclerotic plaques are oligo-clonal, derived from few expanding cells, within mice. Lineage tracing also revealed that the progeny of individual VSMCs contribute to both alpha Smooth muscle actin (aSma)-positive fibrous cap and Mac-3-expressing …
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Gamma-Glutamyltransferase- Is it a Biomarker of oxidative stress?
… of LDL and active GGT has been observed in atherosclerotic plaques. Prospective studies have also recently shown that plasma GGT levels may be correlated with cardiovascular disease, however the mechanism remains unclear. This research examines the hypothesis that it is due to an increased …
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Factors affecting the binding of lecithin:cholesterol acyltransferase with interfacial substrates
… cholesterol diffusion from cell membranes and atherosclerotic plaques and plays a critical part in the maintenance of cholesterol homeostasis. The principal protein of HDL, apolipoprotein A-I (apoA-I) is a major physiological activator of the LCAT reaction. Despite the importance of this …
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Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease.
… is a cardiovascular disease which forms plaques which narrow the arteries, restricting blood flow and thus increasing blood pressure. As this can lead to more serious conditions, such as myocardial infarction, it is important that atherosclerosis is treated to prevent dangerous levels of …
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Identification of potential clinical indicators of carotid plaque disruption using patient specific finite element modelling
… the arterial wall may provide an indicator of atherosclerotic plaque disruption. Many studies have used patient specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. This thesis …
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Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients
… VH and VL sequences of the Fab produced from the plaques and comparison them with those from PBMC. This study will improve the knowledge of the mechanism which are related to the pathogenesis of atherosclerosis and provide a basis for developing of new therapeutics which can regulate the …
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