Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"atheroma"”.
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Use of Echogenic Immunoliposomes For Delivery of Both Drug and Stem Cells For Inhibition of Atheroma Progression
… of both Drug and Stem Cells for Inhibition of Atheroma Progression </strong></p> <p>By Ali K. Naji B.S. Advisor: Dr. Melvin E. Klegerman PhD</p> <p><strong>Background</strong> and significance: Echogenic liposomes can be used as drug and cell delivery vehicles that reduce atheroma progression. …
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Multimodal Imaging of Inflammation at the Neurovascular Interface in Cerebrovascular Disease
… are histopathological features of atheroma at risk of rupture (so-called “vulnerable plaques”) that trigger thromboembolic stroke. While conventional clinical imaging simply measures the degree of vessel stenosis, it is a crude measure that reveals little of the metabolic processes …
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The relationship between intravascular ultrasound-derived percent total atheroma volume and fractional flow reserve in the intermediate stenosis of proximal or middle left anterior descending coronary artery
… ultrasound [IVUS]-derived percent total atheroma volume [%TAV]), correlates with functional severity of intermediate stenosis of left anterior descending artery (LAD). An IVUS study and fractional flow reserve (FFR) measurements performed in 130 patients with coronary angiographic …
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Numerical and experimental modeling of atherosclerosis related to MRI
… MRI has the advantage of being able to detect atheroma in blood vessels with no risk to the patient but is still limited in its application to large blood vessels by the low geometrical resolution obtainable. The capability of MRI to measure velocities as well leads to the idea of correlating …
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Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography
… of plaque rupture and to monitor the effects of atheroma-modifying therapies. This is important since recent studies strongly suggest that HMG Co-A reductase inhibitors promote plaque stability by decreasing plaque macrophage content and activity without substantially reducing plaque size and …
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Imaging microcalcium in thoracic aortic disease
… of the thoracic aorta occurs in two major forms; atheroma and aneurysm formation. Both disease processes progress silently before catastrophic complications occur, such as stroke or aortic dissection. Current management strategies focus on preventative interventions which can include high-risk …
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Investigation of the mechanisms underlying the development of atherosclerosis.
… is considered the driving force behind atheroma development and is regulated by the concerted activities of several cytokines, chemokines and adhesion molecules, expressed by vascular endothelial and smooth muscle cells. The chemokines CCL2 and CX[3]CL1, which influence the migration of …
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Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
… and accumulation causing plaque growth and atheroma formation. Hyperlipidemia and other risk factors for cardiovascular disease promote the conversion of LDL to ox-LDL, which causes insult to the vascular wall. One of the earliest events of atherogenesis is the adhesion of circulating …
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A Fluid Structure Interaction Model Of Intracoronary Atherosclerotic Plaque Rupture
… shed light on the mechanism that causes unstable atheroma, none has directly addressed the clinical observation that most myocardial infarction (MI) patients have moderate stenoses (less than 50%). Considering the important role the arterial wall compliance and pulsitile blood flow play in …
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Relationship Between Intravascular Ultrasound Parameters and Fractional Flow Reserve in Intermediate Coronary Artery Stenosis of Left Anterior Descending Artery
… plaque volume (r= -0.345, p<0.001) and percent atheroma volume (PAV) (r=-0.398, p<0.001). Lesions with significant ischemia (FFR <0.80) as compared to those with FFR >0.80 were associated with larger plaque volume (181.8±82.3 vs. 125.9±77.9 mm3, p<0.001) and PAV (58.9±5.6 vs. 53.8± 7.9 %, …
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LUMEN SEGMENTATION IN INTRAVASCULAR ULTRASOUND DATA
… minimum lumen cross-section area, and total atheroma volume. This information is crucial for making decisions such as whether a stent is needed to restore blood flow in an artery and to determine the characteristics of the stent. Other applications of IVUS include the study of mechanical …
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Development of a Passive Immunization Strategy Against Atherosclerosis
… The characteristic culprit of the disease is the atheroma, or atherosclerotic plaque, a patchy thickening of the arterial wall which affects the lumen, inducing various degrees of stenosis. The rupture of the atherosclerotic plaques, followed by local thrombosis, is the underlying cause of …
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Effects of nutrition and ultrasound imaging on the cardiovascular system
… contrast ultrasound on von Willebrand Factor and atheroma thickness were observed. Next, another rabbit study was performed to assess the effect of contrast ultrasound on Hsp70, a cellular stress protein. The ultrasound procedure was hypothesized to elevate Hsp70 protein levels. Hsp70 protein …
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X-ray phase contrast imaging of preclinical atherosclerosis
… coronary syndrome (ACS) following rupture of an atheroma, an event that is poorly predicted and remains the most common first indicator of cardiovascular disease. Current tools for determining atherosclerotic burden rely assessing a patient's risk factors, clinical symptoms, and biochemical …
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Impact of Percutaneous Transluminal Intervention on Vascular Hypoxia and the Role of Micro-calcifications on Atherosclerotic Plaque Rupture
… the endothelium, which evolves into a fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically stenotic) or become mechanically unstable with a higher chance of …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… double knockout (DKO) mice show accelerated atheroma development. The present thesis tested the hypothesis that inactivation of 11β-HSD2, allowing inappropriate activation of MR in cells of the vasculature, accelerates atherogenesis through promotion of a pro-inflammatory environment with …
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Characterization of native and bypass human coronary artery plaque deposits from the same heart: investigation of the chemical form of calcium in human coronary artery plaque deposits
Gradual deposits of lipids, proteins, and calcium on the coronary arterial walls cause atherosclerosis, leading to blockage of the blood flow and possible heart attack. Despite many studies, the mechanism underlying these processes remains unclear. In this research, differences between native and …