Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"atenolol"”.
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Pharmacodynamic evaluation of beta-blockade associated with atenolol in healthy dogs
… Dosing intervals of 12 and 24 hours for atenolol have been recommended, but an evidentiary basis is lacking. To test the hypothesis that repeated, once-daily oral administration of atenolol attenuates the heart rate response to isoproterenol for 24 hours, we performed a double-blind, …
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Comparative effects of calcium channel antagonism and beta-1 selective blockade on exercise performance in physically active hypertensive patients
… calcium channel antagonist, to those of atenolol, a β₁-selective antagonist, on maximal and submaximal exercise performance and on short duration high-intensity exercise in physically active hypertensive patients. The study design was a crossover trial where drug treatments were double …
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Effects of Portuguese Man-of-War (PHYSALIA PHYSALIS) Venom on Isolated Rabbit Atria
… attenuated by diltiazem (0.8 µM) and atenolol (10 µM). Atenolol, a β1-adrenergic antagonist, completely blocks the increase in heart rate. Dantrolene (10 µM) did not significantly block the venom's effects. Ryanodine binding increases in the presence of venom showing that the venom is …
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Investigating human pharmaceutical compounds present in municipal and hospital wastewaters and options for their removal
… (> 1 μg/L), followed by carbamazepine, atenolol, lidocaine, sulfamethoxazole and NACS (<1 μg/L). In hospital wastewater treatment plants (HWWTPs), the highest concentrations measured were for paracetamol and caffeine (> 10 μg/L), followed by ciprofloxacin and NACS (1–6 μg/L), and finally …
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Effect of ivabradine, a novel I<sub>f</sub> current inhibitor, on dynamic obstruction of the left ventricular outflow tract in cats with preclinical hypertrophic cardiomyopathy: a single-dose study
… outflow tract obstruction received one dose of atenolol at approximately 2 mg/kg PO or one dose of ivabradine at 0.3 mg/kg PO. Baseline and 3-hour post-treatment heart rate, echocardiographic variables, and blood pressure were recorded. Statistical comparisons were made using analysis of …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
… two widely used antihypertensive drugs, atenolol and hydrochlorothiazide that are cleared predominantly by the kidney but the molecular mechanisms involved in its renal secretion are virtually unknown. Using a panel of HEK cell lines stably expressing major renal drug transporters and …
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Arrhythmogenic potential of alpha-adrenoceptor stimulation in the rat heart
… of the beta-adrenoceptor antagonist agent, atenolol; furthermore no accumulation of cyclic AMP, the proposed arrhythmogenic second messenger of beta-adrenoceptor stimulation, occurred. Similarly no alteration in heart rate, coronary flow rate or myocardial high energy phosphate content …
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Essential Function of Ghrelin in Chronic Starvation
… or epinephrine, an effect blocked by atenolol, a selective β1-adrenergic antagonist. Treating WT mice with atenolol or reserpine, a drug that depletes adrenergic neurotransmitters from sympathetic neurons, blocked the fasting-induced increase in plasma ghrelin. Thus, ghrelin secretion …
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Sublingual drug delivery: In vitro-in vivo correlation
… (3.95±0.29)×10 –5 , (4.75±0.81)×10 –5 and Atenolol: (2.01±0.68)×10 –6 , (2.95±0.32)×10 –6 cm/s, respectively (p>0.05). The discrepancy between in vitro and in vivo system was hypothesized in this study to be due to the difference in thickness and role of extensive microcirculation in the …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… [GCDCA-S], levocetirizine, ergothioneine, and atenolol) for the major renal uptake transporters (OAT1–4, OCT2, OCTN1/2) and for renal efflux transporters (P-gp, BCRP, MRPs, MATE1/2-K) using transporter-overexpressing HEK293 and MDCK-II cells and Sf9 membrane vesicles. Cidofovir, levocetirizine, …
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Ocorrência e distribuição de fármacos, cafeína e bisfenol-a em alguns corpos hídricos no Estado do Rio de Janeiro
… carbamazepina, diazepam, lorazepam, venlafaxina, atenolol, metoprolol, nadolol, propanolol, sotalol, furosemida, torasemida, glibenclamida, irbesartan, losartan, valsartan, warfarina, tiabendazol, xilazina, sulfametoxazol, trimetoprim), cafeína e bisfenol-a, empregando a técnica analítica de …
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Hemodynamic outcomes of weaning intraaortic balloon counterpulsation in heart failure
… closed chest model of heart failure using atenolol and halothane was induced prior to the weaning treatment. Subjects were randomly assigned to one of two groups (RV or VR). For Group RV, the assist rate was weaned first (Pattern R) followed by the balloon volume (Pattern V). For Group VR, …
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Deactivation and regeneration of immobilized titanium dioxide photocatalysts during treatment of pharmaceutical micropollutants in groundwater
… (GW). GW spiked with four model PPCPs (5 µg/L atenolol, sulfamethoxazole, carbamazepine, and 10 µg/L iopromide) was treated with immobilized thin films of TiO2 coated on glass slides under UV-A light in a serpentine plug-flow reactor. Initially, catalysts achieved 50-75% degradation of influent …
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Síntesis y caracterización de hidrogeles de alginato y n-isopropilacrilamida para aplicaciones biomédicas
… Estudios preliminares de liberación de atenolol empleando hidrogeles termosensibles, preparados a partir de los copolímeros de injerto obtenidos por irradiación, mostraron una liberación de aproximadamente un 70 % del contenido inicial del fármaco en el hidrogel en la primer hora de …
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Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
… to reduced sensitivity to beta-blockers such as atenolol and consequently reduced efficacy. The NEDD4L rs4149601A allele results in a non-functional NEDD4L, impacting antihypertensive drugs with renal mechanisms, such as hydrochlorothiazide and amiloride. Conclusion CYP3A5 rs776746T>C, NOS3 …
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CYTO-GENOTOXIC EFFECTS OF SOME PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) ON THE FRESHWATER BIVALVE ZEBRA MUSSEL (DREISSENA POLYMORPHA)
… the potential in vitro cytotoxicity of atenolol (ATL), carbamazepine (CBZ), diclofenac (DCF) and gemfibrozil (GEM) and to discriminate the most sensitive cell type for further applications. On overall, DCF was the more cytotoxic compound for zebra mussel cells, followed by GEM, CBZ and …