Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"atazanavir"”.
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… characterized the DDI between ritonavir-boosted atazanavir (ATV/r) and rifampicin, both in plasma and within peripheral blood mononuclear cells (PBMCs). Rifampicin increased the clearance of ATV/r by threefold, and doubling the dosing frequency of ATV/r was sufficient to counteract this …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… drug transporters in the tissue distribution of atazanavir and observed that P-glycoprotein/breast cancer resistance protein (Mdr1a/1b-/-. Abcg2-/-) knockout mice and wild-type mice pre-treated with the P-glycoprotein and breast cancer resistance protein inhibitor, elacridar, have enhanced …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… retroviral protease inhibitors Ritonavir, Atazanavir and Lopinavir which could be potentially repurposed for the treatment of Merlin-deficient schwannoma and grade I meningioma. Ritonavir and Lopinavir effectively decreased the proliferation of Merlin-deficient primary schwannoma cells at …
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… the stability of supersaturated solutions of atazanavir, a weakly basic PWSD, relative to trihydroxy species. In addition, the crystallization onset of atazanavir in media designed to mimic a range of representative healthy subject intestinal fluids exhibited a bile salt …
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Evaluating individuals with extreme phenotypes of HIV-1 contributes towards better healthcare management of all HIV-1 positive individuals
… initiating boosted protease inhibitor, atazanavir might be preferable compared to lopinavir, with 30% lower mortality risk, and 9% lower virological failure risk, which could lead to lower transmitted drug resistance (TDR). We found TDR was significantly decreasing throughout Europe, but …
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… that HIV protease inhibitors, such as lopinavir, atazanavir, saquinavir and ritonavir, significantly enhanced the antifungal activity of azoles (fluconazole, voriconazole, itraconazole, and posaconazole) and polyene (AmB). Mechanistic studies showed that the HIV protease inhibitors inhibited the …