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Showing 1 to 12 of 12 for “"asymmetric transfer hydrogenation"”.
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Asymmetric Transfer Hydrogenation of Secondary Allylic Alcohols
… a ruthenium catalyzed tandem isomerization and asymmetric transfer hydrogenation reaction. This reaction is a one pot, two-step process, which utilizes the unique ability of a transition metal catalyst to effect a combined reduction of the C-C double bond and the carbonyl group in a selected …
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Applications of Green Chemistry in Asymmetric Transfer Hydrogenation and Chiral Separations
… In this thesis, I report the first Ru-catalysed asymmetric transfer hydrogenation (ATH) of prochiral allylic alcohols. This reaction provides chiral secondary alcohols in excellent enantioselectivities and yield. This new reaction is much safer, more economical and environmentally friendly for …
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Design and modification of rhodium and iridium N-heterocyclic carbene complexes for asymmetric transfer hydrogenation and antimicrobial activity
… design of iridium NHC amino acid complexes for asymmetric transfer hydrogenation (ATH) of prochiral ketones. Iridium(I) bis-NHC complexes were found to undergo oxidative addition with a variety of alpha-amino acids, generating chiral iridium(III) complexes of the form Ir(NHC)2(aa)(H)(X) (aa = …
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Increasing the Stability and Turnover Number of a Highly Active Iron Catalyst for the Asymmetric Transfer Hydrogenation of Ketones
A highly active iron catalyst for the asymmetric transfer hydrogenation (ATH) of ketones was reported by the Morris group in 2013. This catalyst surpassed the activity of platinoid metals by reaching TOFs up to 200 per second, but the highest reported turnover number (TON) was only 6060. To compete …
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Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
… (aa = α-amino carboxylate), and their utility as asymmetric transfer hydrogenation catalysts of ketones. Variation of the metal center, the n-ring, and the aa was used to tune these systems for specific sets of ketones. Upon reaction with homochiral]s, the ligand environment in all of these …
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Development and application of calibration free techniques for reaction profiling
… problems, which include the rhodium catalysed asymmetric transfer hydrogenation reaction of a prochiral imine, the pyridine catalysed esterification reaction of acetic anhydride and the vinyl acetate monomer process. These chemical systems are typically deficient in a priori information leading …
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Activating Aldehyde C-H Bonds: Applications to Hydroacylation and Transfer Hydroformylation
… with high enantiomeric excess by using Noyori's asymmetric transfer hydrogenation catalyst. This overall-oxidative reaction is inhibited by oxidant (acetone) and autocatalytic in a reductant (iso-propanol). Chapter 4 describes the development of a transfer hydroformylation protocol. Reactivity at …
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METAL CATALYSED TRANSFER HYDROGENATION, DEHYDROGENATION AND RACEMISATION OF AMINES
… study of the fundamental mechanisms relating to asymmetric transfer hydrogenation (ATH) of imines and the transfer dehydrogenation and racemisation of secondary amines by Cp*Rh and Cp*Ir complexes. A series of 16-electron complex of the type Cp*M(XNC6H4NX’) (where M = Rh or Ir and X, X’ = H or …
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Design and Application of Transition Metal Complexes for Catalysis
… and its application in the transition-metal asymmetric transfer hydrogenation (ATH) reaction of converting ketones to chiral alcohols in good yields and high enantiomeric excess. The third chapter highlights some of the unexpected observations encountered from several of our peptide designs …