Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"asymmetric dimethylation"”.
-
Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… of a novel methylation site on histone H3, the asymmetric dimethylation of arginine 42 (H3R42me2a). H3R42 is conserved through evolution and is at the DNA entry/ exit position within the nucleosome core, with likely interactions with the DNA backbone. I show that methyltransferases CARM1 and …
-
The Regulation of Dna Methylation In Mammalian Development and Cancer
… an arginine methyltransferase responsible for asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a), negatively regulates maintenance DNA methylation by impairing the recruitment of the Dnmt1-Uhrf1 complex to chromatin, thereby identifying a novel crosstalk between histone arginine …
-
The Design, Synthesis and in vitro Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Degradation of Protein Arginine Methyltransferase 1
… 1 (PRMT1) is a protein responsible for the asymmetric dimethylation of arginine. PRMT1 is upregulated in a wide range of cancers and the reduction of PRMT1 activity reduces cell proliferation and tumour growth in cell and animal models of cancer. A reduction in PRMT1 can also sensitise …
-
Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… PRMT6 induction, both mouse models show elevated asymmetric dimethylation of H3R2 compared to wild type mice, demonstrating for the first time that PRMT6 methylates this residue <em>in vivo</em>. The ER*-PRMT6 mice die upon stabilization of the chimera and serum analyses have revealed elevation of …
-
Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… be modified in three different ways to produce asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and monomethylarginine (MMA). These modifications are catalyzed by a family of nine protein arginine methyltransferases (PRMT1-9), which are of three types (I, II, and III). The …