Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"asymmetric dimethylarginine"”.
-
Characterizing The Recognition Motif and Novel Substrates of Carm1
… role in transcriptional regulation. It deposits asymmetric dimethylarginine (ADMA) marks on both histone and non-histone proteins. We performed a comparative proteomic screen with Pan-methylarginine (Rme2a) antibodies and identified that Nuclear Factor I-B (NFIB) is a major CARM1 substrate. …
-
Nitric oxide in airway inflammation
… (CSE) induced significantly higher NOx and asymmetric dimethylarginine (ADMA) levels in A549 cells when compared with control media. The anti-oxidant, NAC pre-treatment partially reversed the elevated NOx levels but not the ADMA levels. This thesis is the first to report FENO and EBC NOx in …
-
Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity
… important means of NO downregulation is through asymmetric dimethylarginine (ADMA), an endogenous NO inhibitor, which is largely metabolized by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). The activity of DDAH is impaired by oxidative stress, thereby permitting ADMA to accumulate …
-
Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… be modified in three different ways to produce asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and monomethylarginine (MMA). These modifications are catalyzed by a family of nine protein arginine methyltransferases (PRMT1-9), which are of three types (I, II, and III). The …
-
Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… forward by Ahmetaj-Shala et al., suggests that asymmetric dimethylarginine (ADMA) may serve as a mechanistic bridge between COX-2 inhibition and HF. However, the ADMA-COX-2 hypothesis was developed based on findings in a constitutive mouse model of COX-2 knock-out (KO), which is compromised by …
-
Der Einfluss von diätetisch verabreichten Sojaisoflavonen auf den Homocysteinmetabolismus und die Endothelfunktion bei gesunden, postmenopausalen Frauen
Homocystein (tHcy) gilt als unabhängiger kardiovaskulärer Risikofaktor und korreliert eng mit einer endothelialen Dysfunktion, welche nichtinvasiv mittels der flussinduzierten Vasodilatation (FMD) messbar ist. Experimentelle Hyperhomocysteinämie ist mit einer reduzierten Bioverfügbarkeit von …