Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"astrogliosis"”.
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Cyclic AMP and the Induction of Reactive Astrogliosis
… referred to as reactive astrocytosis. Reactive astrogliosis can be modeled in vitro using mechanical (scratch wound) or chemical stimuli to activate F98 rat glioblastoma cells from a quiescent state to a reactive-like state. Studies have shown monoclonal antibody (mAB) Jl-31 may recognize a …
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Role of JAK2 in the Proliferation of Activated Astrocytes
… have some regenerative properties, the astrogliosis is thought to be a barrier to repair in the central nervous system. The activated astrocytes secrete many types of cytokines and inflammatory mediators, which might be associated with JAK2/STAT pathway. Although the inhibition of JAK2 …
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Regulation of Astrocyte Functions by a Parkinson's Disease Gene, DJ-1
… . 7 2. Reactive astrocytes : function of astrogliosis in neural protection . 8 3. Reactive astrocytes : function of astrogliosis for regeneration and repair . 9 4. Reactive astorycytes : functin of astrogliosis for regulation of inflammation . 11 E. Astrocyte dysfunction in …
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The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
<p>Astrogliosis is induced by neuronal damage and is also a pathological feature of the major aging-related neurodegenerative disorders. The mechanisms that control the cascade of astrogliosis have not been well established. In a previous study, we identified a novel androgen receptor …
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Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury
… upregulated, edema was prominent, and reactive astrogliosis occurred. When siAQP4 was administered after jTBI, there was functional improvement, decreased edema, and decreased reactive astrogliosis. When siCx43 was administered, there was functional improvement and decreased reactive …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
… spinal cord injury. Importantly, the extent of astrogliosis and extracellular matrix remodelling that could limit or enhance neural progenitor cell (NPC) graft efficacy in DCM is unknown. The first aim of this project was to examine changes in the extracellular matrix in DCM. …
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The Combined Effect of In-Situ Tumor and Irradiation on Peritumoral Brain Vasculature
… protein expression in the peritumoral region. Astrogliosis, an increase in reactive astrocytes associated with inflammation, was detected in the peritumoral region and contralateral to the tumor. </p> <p>RT of the implanted tumors caused a significant increase in BBB permeability and in adhered …
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Modulating System xc- Activity As A Treatment For Epilepsy
… SAS in reducing seizure burden in vivo using an astrogliosis-mediated epilepsy mouse model. In this dissertation we show that (1) SXC inhibition, using SAS, is able to decrease induced epileptiform activity in multiple models of chemically induced hyperexcitability (2) this is due to a …
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A STUDY ON THE BIOCHEMICAL AND CELLULAR EFFECTS OF ENVIORMENTAL TOBACCO SMOKE ON ADULT AND DEVELOPING RAT BRAIN BIOCHEMISTRY
… ETS exposure study, we focused on markers of astrogliosis , oxidative stress, and cell death. We observed altered GFAP suggestive of reactive astrogliosis. Yet, markers of oxidative and cell stress were unaffected by ETS exposure in the brain regions examined. Increased degradation of …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… granule cell dispersion, volume reduction and astrogliosis. Amygdalar volume and neuronal loss was observed in the ipsilateral nuclei which was accompanied by astrogliosis. In addition, a decrease in Y1 receptor expressing cells in the ipsilateral CA1 and CA3 sectors of the hippocampus, ipsi- …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… alleviated the strong neuroinflammation and astrogliosis in AD model APP/PS1 mice. NOB also significantly improved glucose utilization and insulin signaling in these mice. Furthermore, I report initial evidence for a possible NOB-ROR downstream mechanism through Ephrin signaling and the NF-κB …
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Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System
… microglial activation. Moreover, increased astrogliosis, and elevated CNS expression of pro-inflammatory cytokine mRNA were observed in SDEL recipient mice. Additionally, SDEL injected directly into the cerebral ventricles resulted in significant microgliosis as well as, astrogliosis. …
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Endosomal Trafficking and Exosomal Secretion of Egfrviii
… induce changes in astrocytes that mimic reactive astrogliosis including an increase in glial fibrillary acidic protein (GFAP) and altered astrocyte morphology.</p> <p>These results reveal novel aspects of the endocytic trafficking of EGFRvIII that underlie its reduced degradation and the mechanism …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… blood vessels with enhanced perivascular astrogliosis. Additionally, β8 integrin dependent defects in NSC proliferation, survival, and differentiation, as well as neuroblast migration in the RMS were observed both in vivo and in vitro. The defects correlated, in part, with diminished …
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… signaling in neuropsychiatric disorders 41 F. Astrogliosis 41 Ⅱ. MATERIALS AND METHODS 44 1. Animals 44 2. Brain section preparation and Immunohistochemistry 44 3. Stereological analysis 45 4. Western blot analysis 45 5. Statistical analysis 46 Ⅲ. RESULTS 47 Ⅳ. DISCUSSION 64 Ⅴ. CONCLUSION 66 …
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EPIGENETIC AND FUNCTIONAL ASSESSMENT OF ENHANCEROPATHIES ACROSS HUMAN MODELS: FOCUS ON GABRIELE-DE VRIES SYNDROME
… synaptic disparities, sufficient to induce astrogliosis-like features in surrounding astrocytes, both shown to be critical for proper brain function and plasticity forms in the CNS. Instead, in cortical organoids we recapitulated features of abnormal ventricle formation, pathological …
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
The process of astrogliosis, or reactive gliosis, is a typical response of astrocytes to a wide range of physical and chemical injuries. The up-regulation of the astrocyte specific glial fibrillary acidic protein (GFAP) is a hallmark of reactive gliosis and is widely used as a marker to identify …
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The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… astrocyte reactivity, inflammatory response and astrogliosis. In addition, I demonstrated that on stiff substrates astrocytes phenocopy aged cells on both transcriptional and functional level. Consequently, astrocytes on stiff substrates secreted ECM that significantly inhibited OPC proliferation …
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Generation of focal Depdc5 knockout mouse model and implications for focal epilepsy
… identified, such as hypomyelination, reactive astrogliosis, and microglial activation. Our focal Depdc5 knockout mouse model recapitulates clinical, pathological, and biochemical features of human DEPDC5-related epilepsy and brain malformations. Our study reveals that postnatal DEPDC5 loss …
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The role of blood-borne factors in triggering atypical astrocytes
… TBI, exposure to blood-borne factors triggers astrogliosis via upregulation in markers, such as glial fibrillary acidic protein (GFAP), but how exposure to blood-borne factors affects astrocyte protein expression in the context of mTBI is not well understood. Therefore, we hypothesized that …
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