Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"astroglia"”.
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Biohybrid Neural Interfaces: Exploring the Role of Regional Astroglia in Neuronal Integration and Functionality
… potentially impacted either by co-transplanted astroglia immediately post-implantation or by those existing in the host neuronal tissue. Importantly, astroglia may exert diverse impacts on these neurons due to their regional heterogeneity, however, this aspect is less often addressed in current …
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Neuron-glial interactions in dendrite growth
… between central nervous system neurons and astroglial cells that regulate dendrite growth from cerebral cortical neurons. Embryonic (E18) mouse cerebral cortical neurons were cocultured with early postnatal (P4) rat astroglia derived from cerebral cortex, retina, olfactory bulb, …
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Advances in Two-Photon Fluorescence Microscopy for High-Resolution Anatomical and Functional Imaging of Cell Populations in the Intact Brain
… wurde eine Methode zur spezifischen Färbung von Astroglia entdeckt und die transgene Expression von fluoreszierenden Proteinen zur Mikrogliazellfärbung eingesetzt. Mit einem Standard-Zwei-Photonen Mikroskop konnte gezeigt werden, daß sich Neurone und Astroglia im adulten Gehirn morphologisch kaum …
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Analyzing The Role of Αvβ8 Integrin In Glioma-Induced Angiogenesis
… in glioma-induced angiogenesis. Primary mouse astroglia were cultured from wild type (WT) and β8 KO neonates and were immortalized (HPV:E6/E7) and transformed (HRas:G12V). WT and β8 KO transformed astroglia were intracranially injected into athymic mice. WT tumors displayed pathological …
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Immunomodulatory function of astrocytes characterization and regulation of postanoid metabolism and cytokine synthesis
… immunological processes in the brain. Thus, astroglial-derived immunomodulatory factors are integrated in the complex scenario of glia-glia and glia-neuron cell to cell communication during pathological processes. I have shown for the first time in detail that mouse neonatal cortical …
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Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
… weeks after MDMA discontinuation. Activation of astroglia and microglia by GFAP and CD11b immunohistochemistry in motor areas, as substantia nigra compacta (SNc) and striatum, limbic and cortical areas, as hippocampus and medial prefrontal cortex (mPFC), was assessed. Degeneration of dopaminergic …
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Traumatic Injury-Induced Cell Responses in Human Cortical Organoids
… results highlight potential differences in fetal astroglia-microglia interactions to that found for the adult brain and provide a unique platform for cell interaction-based studies with broad relevance to TBI pathogenesis and therapeutics.
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… amyloid plaques, activated microglia and astroglia, as well as hyperphosphorylated tau. In addition, our mechanistic <i>in vitro</i> experiments delineated SYK as a regulator of autophagic tau degradation via the mTOR pathway. These data were confirmed in an <i>in vivo</i> study, assessing …
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Exploring the potential for biomarkers to aid forensic diagnosis of traumatic brain injury (TBI) – a systematic literature review and meta-analysis
… interleukin (IL)-1β, IL-6, and IL-10 and astroglia-associated biomarkers S100 Calcium-Binding Protein B (S100β) and Glial Fibrillary Acidic Protein (GFAP), have been assessed as potential TBI biomarkers. The aim of this review was to evaluate recent articles that investigated these …
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Vigorous orientated fibre outgrowth of adult sensory axons after microtransplantation into the central nervous system grey matter : an investigation into orientation and possible growth substrates
… axons did not follow the random pattern of host astroglia and their processes, but demonstrated substantially orientated outgrowth, possibly directed towards certain thalamic nuclei. In an attempt to clarify the issue of the substrate responsible for supporting such strong axonal outgrowth, …
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Cytochrome c oxidase mediates the regulation of mitochondrial function in an in vitro model of Huntington's disease
… in astrocytes, which could affect proper astroglia function under pathological conditions and, in turn, indirectly contribute to reduction of neuronal survival. Along with this, the fact of different brain regions responding differently to toxic conditions was highlighted and could explain …
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Using Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice
… synaptically-interconnected neurons, astroglia and microglia. This CNS analogue of brain tissue provides for the emergence of a co-ordinated excitatory and inhibitory network, demonstrating a maturing pattern of activity involving single spikes developing into bursting behaviour driven …
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Generation and circuit development of zebrafish retinal horizontal cells
… of its synaptic circuits and associations with astroglia. HCs are a key component of the circuitry of the outer retina of vertebrates and they function to modulate information transfer from photoreceptors. I examined the genesis of HCs using in vivo multiphoton time-lapse microscopy in the …
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Jagged1 regulates adult neural stem cell maintenance and multipotency through activation of Notch1
… Stammzellen noch in <br>der Lage, Neuronen, Astroglia und Oligodendrozyten zu bilden in vergleichbaren <br>prozentualen Anteilen wie Wildtyp-Zellen. Mittels semiquantitativer RT-PCR konnte aufgezeigt werden, daß die direkten Ziele des Notch-Signalwegs, die Transkripte von Hes1 und Hes5 ein …
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CNS Neural/Glial Progenitors as Targets of HIV-1 and Opiates: Effects on Proliferation and Population Dynamics May Alter Behavior Outcomes.
… Tat and opiates have interactive effects on astroglial chemokine secretion, but this interaction did not occur in progenitors. We also examined effects of Tat and morphine on proliferation and lineage progression of NPCs in vitro and in vivo. In vitro, Tat and morphine independently reduced …
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Radial Glia and the Migration of Young Neurons in the Adult Avian Brain
… The same antibody also stained a subset of brain astroglia and reacted with non-brain material such as mesenchyme, Sertoli cells and the Z-line of muscle. A weaker reaction was obtained with erythrocytes and some endothelial cells. 40E-C also reacted with radial glia of developing rat brain but …
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Optical Analysis of Mitochondrial Function and Heterogeneity in Cultured Hippocampal Astrocytes
Diese Dissertation beschreibt die Untersuchung mitochondrialer Heterogenität in kultivierten Astrozyten des neonatalen Rattenhippocampus. Im Rahmen der Neurophysiologie und Pathologie erfuhren sowohl die Rolle von Astrozyten als auch jene zerebraler Mitochondrien während der vergangenen zwei …
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Development and application of correlative STED and AFM to investigate neuronal cells
Over the past three decades in cellular neuroscience there has been a shift towards the view of the ``tripartite synapse'', where, astrocytes -- as well as the pre-synapse and post-synapse -- are involved in synaptic signalling. The migration of astrocytes to form branched networks in the brain is, …