Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"astrocytic activation"”.
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The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration
… I hypothesized that FUS induced a transient activation of microglia and astrocyte that is consistent with pro-regenerative functions. Firstly, I developed a method, MORPHological assessment of Outlier clusters (MORPHIOUS), to quantify microglial and astrocytic activation. MORPHIOUS is a …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… chronic pain. Although injury models have shown activation of both astrocytes and microglia following insult, research in other CIPN models has shown astrocytic activation in the absence of microglial activation. The central hypothesis of this dissertation is that the activity of astrocytes is …
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Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
… as drug targets. Microglia and astrocyte activation, first observed by Alois Alzheimer in 1907, have been reevaluated as potential contributors to AD progression rather than bystanders. Recent studies indicate that microglial dysfunction and neuroinflammation, likely play significant roles …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… investigating neuroinflammatory signalling and activation of microglia and astrocytes in the brain. To validate this model of neuroinflammation, OBSCs from neonatal mice were treated with the pro-inflammatory stimulant lipopolysaccharide (LPS) for 24 hours and compared to untreated control …
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The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… many of detailed mechanisms of astrocyte activation remain to be elucidated, a number pathways have been implicated in astrocyte activation including p21<sup>Cip1</sup> and the NF-kB pathway. Astrocytic activation induced by p44/WDR77 gene deletion was associated with a significant …
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The role of the cold shock protein, RBM3, in cooling, synaptic structural plasticity and neuroprotection
… well understood. Alongside neuronal pathology, astrocytic activation is a hallmark of many neurodegenerative diseases. Astrocytes play a key role in support of synapses and in regulating structural plasticity. In this thesis, I use in vitro and in vivo approaches to examine the hypothesis that …
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Functions of Mediodorsal Thalamic Astrocytes in Cue-Based Learning
… relays, the precise mechanisms underlying its astrocytic activity, its contribution to synaptic plasticity, and the subsequent effects on cognitive processing remain poorly understood. Emerging data highlights the pivotal role of astrocytes in regulating synaptic transmission, with astrocytic …
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COGNITIVE TRAINING AND FUNCTIONAL RECOVERY IN AN AGED MODEL OF TRAUMATIC BRAIN INJURY
… measures of blood - brain barrier compromise or astrocytic activation. These findings indicate that cognitive training can confer positive results, even in the most aged or cognitively impaired individuals. These effects were achieved even though the olfactory discrimination cognitive training …