Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"association study"”.
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A Family-Based Association Study of Conduct Disorder.
… We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data is gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE).</p><p>Using COGA data, we identified 20 markers which …
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Genome-wide association study of persistent developmental stuttering
A genome-wide association study (GWAS) is an approach that involves scanning markers across complete sets of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who …
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Genome-wide association study for sperm motility in pigs
A qualidade do sêmen de reprodutores suínos pode ser avaliada de acordo com vários critérios, sendo a motilidade espermática o mais utilizado e importante. A motilidade, essencial para a fertilização, refere-se ao movimento retilíneo dos espermatozóides. Apesar da importância da avaliação de …
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Genome-wide association study of muscle traits in Icelandic sheep
… Erfðamengis-tengslagreining (e. genome-wide association study) var framkvæmd annars vegar með BLUP einkunn sem eiginleika og hins vegar með öll sýnin skipt í tvo hópa; valið vöðvafé og óvalið fé sem tilfelli og viðmið (e. case/control). Fáir einbasabreytileikar voru tölfræðilega marktækt …
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Genetic Association Study of Osteoporotic Vertebral Compression Fractures in Postmenopausal Women
… fractures in postmenopausal Korean women. The study subjects consisted of 82 patients with osteoporotic vertebral compression fractures and 117 control postmenopausal Korean women. PCR-RFLP and real-time PCR assay were used to analyze VEGF, MTHFR, and TS polymorphisms. Homocysteine levels were …
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Functional Genome Wide Association Study in Susceptibility and Resistance of Malaria
… and various functional analysis across three study populations in Africa ( Kenya, Malawi and Gambia ). Method and Materials: Our first analysis is directed to the Genome Wide Association Study (GWAS) of three study populations (Kenya, Malawi and Gambia) using the Emmax tool to identify the …
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Association Study of CHRM2 Polymorphisms with Substance-Use Pathology and Personality Traits
A growing literature exists on the association of CHRM2 (the gene coding for cholinergic muscarinic receptor 2) with alcohol dependence (Wang et al., 2004), with the broader phenotype of substance dependence in general (Luo et al., 2005; Dick, Agrawal, et al., 2007), and with the still-broader …
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A Genome-Wide Association Study on Widespread Pain using the UK Biobank Cohort
… to other sitespecific pains. The aim of this study was to explore the genetic variants associated with widespread pain in a cohort of UK Biobank participants who had completed a pain phenotyping questionnaire.<br/><br/><b>Method</b>: Cases and controls were determined by a question answered by …
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Genome-wide association study of Pseudomonas aeruginosa adaptations to the cystic fibrosis lung
… changes that occur. I performed a genome-wide association study inP. aeruginosausing a variety of analysis methods and several datasets of gene and SNP presence/absence. I determined that the machine learning algorithms random forest and support vector machines performed well on gene …
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Network-based approach for post genome-wide association study analysis in admixed populations
… some existing pathway-based approaches for GWA study analyses, by exploring different implemented methods for combining effects of multiple modest genetic variants at gene and pathway levels. We then propose a graph-based method, ancGWAS, that incorporates the signal from GWA study, and the …
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Genomic Selection and Genome-Wide Association Study in Populus trichocarpa and Pinus taeda
… have important roles in a trait. Genome-Wide Association Studies (GWAS) approaches are therefore complementary to GS, enabling identification of these genes, which may be useful for marker-assisted selection in some traits. In this study, we first estimated heritability for several adaptive …
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A pan-genome wide association study to identify genes associated with invasive Streptococcus pneumoniae
… uncharacterized. In the accessory genome, the study detected the presence of genes from Regions of Diversity (RDs), including Subunits of V-type ATPases and Sodium/solute symporter from RD8a. Enzymes from RD3 catalyzing the capsule synthesis. Subunits of PsrP secY2A2 pathogenicity island from …
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Genetic association study of interleukin 6 receptor and liver X receptor in systemic lupus erythematosus
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. The human interleukin 6 receptor (IL6R) consists of 2 membrane-bound glycoproteins interacting with IL6, which is a …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… risk-stratification following PE. A genome-wide association study (GWAS) was performed in 1250 CTEPH patients, 1492 healthy controls and ~7 million single-nucleotide polymorphisms to identify novel disease loci. The ABO locus was identified as the most significant common variant genetic …
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A Genome Wide Association Study for Fusarium Head Blight Resistance in Southern Soft Red Winter Wheat
… on infected seed heads. The objectives of this study are: 1) evaluate soft red winter wheat (SRWW) lines for resistance to FHB in terms of resistance to initial inoculum (incidence); resistance to spread within the head (severity); resistance to DON accumulation; and resistance to Fusarium …
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Genome-wide association study for non-normally distributed traits: A case study for stalk lodging in maize
… increased the ability of computational tools to study the genetic basis of agricultural traits, notably with the application of the Genome-Wide Association Study (GWAS). A limitation of GWAS is that the assumptions underlying the linear model typically used to conduct the analysis are often …
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GENOME-WIDE ASSOCIATION STUDY OF NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN MASLD: EVIDENCE FROM AN ITALIAN POPULATION
… by performing a cross-sectional genome-wide association study (GWAS) using non-invasive fibrosis markers in a large biobank environment. The analysis was performed in the Milan Biobank, a multicenter cohort of 7,025 individuals encompassing healthy blood donors, metabolic dysfunction …
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A Genome-wide Association Study of Schizophrenia in the South African Xhosa and Generalizability of Polygenic Risk Score across African populations
… not, however, been previously investigated. This study had two aims: the first was to investigate the contribution of common variants to the risk of schizophrenia in the South African Xhosa (SAX) population through genome-wide association study (GWAS) analysis, and to determine if PRS derived from …
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A genome-wide association study of resistance to the yellow rust pathogen (Puccinia striiformis f. sp. tritici) in elite UK wheat germplasm
… Pauline G. M. Bansept-Basler, 2013 A genome wide association study of resistance to the yellow rust pathogen (Puccinia striiformis f. sp. tritici) in elite UK wheat germplasm Identification of marker-trait associations (MTA) in germplasm relevant to breeding program via association mapping (AM) …
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