Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"assembly intermediates"”.
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The Evolution of Ribosome Assembly: Making Ribosomes in the Mitochondria
… a comprehensive understanding of their assembly pathways remains elusive. This thesis presents the first structural characterization of assembly intermediates of the mitochondrial small subunit (mtSSU) in eukaryotes. To gain mechanistic insight into the process of SSU assembly in the …
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Domain swapping as a molecular mechanism in amyloidosis
… suggesting a role of the oligomers as fibril-assembly intermediates. Furthermore, high molecular weight cystatin C immunoreactive components were detected in samples obtained from mice, expressing human L68Q cystatin C, while no such species could be observed in control mice.
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Investigating the early events in proteasome assembly
Proteasome assembly is a rapid and highly sequential process that occurs through a series of intermediates. While the quest to understand the exact process of assembly is ongoing, there remains an incomplete understanding of what happens early on during the process, prior to the involvement of the …
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Mechanisms and Evolution of Mitoribosomal Small Subunit Biogenesis
… between mRNA codon and tRNA anti-codon. The assembly of the ribosome is a complex process which is tightly controlled to generate functional subunits which exhibit high translational accuracy and processivity. During ribosome biogenesis, ribosomal proteins and a multitude of additional …
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The Role of BiP Co-chaperone SIL1 in Marinesco-Sjögren Syndrome Pathogenesis
… no significant accumulation of BiP-associated Ig assembly intermediates or evidence that another molecular chaperone system was used for antibody production in the LPS-stimulated splenic B cells from Sil1Gt mice. ER chaperones were expressed at the same level in wild-type and Sil1Gt mice, …
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Stochastic and physical modeling of fundamental biological processes
… and genome packing initiation during the self-assembly of the T4 bacteriophage. We then describe in detail two systems: an improved model of the lac genetic switch which includes DNA looping in its gene regulation mechanism, and a spatially resolved, whole-cell model of ribosome biogenesis in …
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Investigation of particulate Bluetongue virus vaccines made in plants
… of a mixture of core-like particles (CLPs), assembly intermediates and fully formed VLPs. These optimised methods were sufficient to produce high enough yields of BTV8 and BTV1/8 VLPs with protein yields of 35mg/kg fresh leaf weight (FLW) and 34mg/kg FLW, respectively, to be used in …