Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"aspirin"”.
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Aspirin Resistance
Aspirin is a non-steroidal anti-inflammatory drug. It is used for the prevention of thrombo-embolism in patients at risk for getting them.Aspirin resistance is a term coined from people who take aspirin and still get thrombo-embolism. This discusses on the possible causes of aspirin resistance and …
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Adherence to aspirin treatment during pregnancy
… aimed to investigate treatment adherence to aspirin among Icelandic pregnant individuals and how well they understand the purpose of aspirin use. Also, explore knowledge of risk factors and identify factors contributing to inadequate adherence to aspirin. Preeclampsia is a life-threatening …
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Assessment of the in vitro efficacy of aspirin and aspirin analogues in combination with standard chemotherapeutics in glioma cell lines
… beneficial effect on the prognosis of patients. Aspirin, one of the most commonly used drugs reduces the viability and proliferation of glioblastoma both in vitro and in vivo. This study examined the combination of aspirin or its analogue PN517 with the standard chemotherapeutic (cisplatin) and …
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Genetic Effect of ALOX15 Polymorphisms on Aspirin-Exacerbated Respiratory Disease
… were demonstrated in severe asthmatics and aspirin-exacerbated respiratory disease (AERD). To investigate genetic contribution of ALOX15 in the development of AERD, we performed the genetic association of ALOX15 study in a Korean population. MATERIALS AND METHODS: One hundred-seventy one …
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Modification of aspirin derivatives by coordination to iron and manganese
… new metal complexes of acetylsalicylic acid (aspirin) derivatives have been synthesised. Complexes that were studied were those of manganese (Mn) and iron (Fe).
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Aspirin Use for Prevention of Myocardial Infarction in Rural-Dwelling Elderly
… of this study was to describe the patterns of aspirin (ASA) use for primary and secondary prevention of acute myocardial infarction (AMI). Cardiac risk factors, perception of risk, discussion of ASA use and recommendations from healthcare providers (HCPs) are also described. The sample of 93 …
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Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
BACKGROUND AND OBJECTIVE: Aspirin ingestion can induce a wide range of clinically recognized allergic reactions, including aspirin intolerant asthma (AIA), also called aspirin exacerbated respiratory disease (AERD), aspirin-intolerant urticaria/angioedema (AIU), chronic rhinitis, and anaphylaxis. …
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Aspirin Use Is Associated with Improved Outcomes in Inflammatory Breast Cancer Patients
… metastases. Our previous data suggested that aspirin (ASA) use may be associated with reduced risk of distant metastases in aggressive BC; however, there are no reported studies on the potential benefit of ASA use in patients with IBC. METHODS: Data from patients with non-metastatic IBC …
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Effect of Combination of Aspirin and TRAIL in HeLa Cervical Cancer Cells
… In this study, I studied whether pretreatment by aspirin augmented TRAIL-induced apoptotic death in HeLa cells, which derived from cervical cancer and investigated the underlying mechanism. Methods: Cell viability and proliferation were assessed by MTT assay and cytotoxicity was analyzed by LDH …
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A novel mechanism for the anti-cancer activity of aspirin and its analogues
… costs of chemotherapy. Evidence suggests that aspirin, a non-steroidal anti-inflammatory drug (NSAID) has the potential to decrease incidence of, or mortality from a number of cancers including CRC through several mechanisms of action. However, this evidence is dampened by aspirin’s …
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ASpirin as a treatment for ARDS (STAR): a phase 2 randomised controlled trial
… relevant phase I evidence suggesting that aspirin may be of benefit in the treatment of ARDS. <br/><br/>Objectives: <br/>The aim of the STAR trial (aSpirin as a Treatment for ARDS) was to test the hypothesis that enteral aspirin 75mg was both safe and effective in improving important …
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Potential Energy Surfaces for Intermolecular Proton Transfers in Crystalline Aspirin: A Computational Study
… intermolecular proton transfers in crystalline aspirin. Using these surfaces the importance of intermolecular interactions and excited states to the proton transfer were also explored. In addition, the ability of ab initio molecular orbital methods and density functional theory to model such a …
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Genoprotective effect of aspirin and ibuprofen in human lymphocyte cells. Effect of nano and bulk forms of aspirin and ibuprofen on lymphocytes from breast cancer patients compared with those from healthy females
… aims to study the effect of both ibuprofen and aspirin on DNA damage using peripheral blood lymphocytes from breast cancer patients and comparing the results with those from healthy females as a control using the Comet and micronucleus assays. Western blot analysis (WBA) was used to investigate …
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Verstärkung Butyrat induzierter Apoptose in kolorektalen Karzinomzellen durch Aspirin und Tumor Nekrose Faktor alpha
… in vitro andererseits. Auch für NSAID wie Aspirin belegen epidemiologische Studien einen chemoprotektiven Effekt gegenüber dem Kolonkarzinom. Für das Zytokin TNFalpha werden einerseits apoptoseinduzierende Effekte für kolorektale Karzinomzellen in vitro beschrieben, jedoch gelten einige …
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Novel Cellular Targets of Aspirin in Chemoprevention studies on P53, G6PD and c-MYC
<p><strong>Background</strong></p> <p>Aspirin has generated a significant interest in recent years as a potential chemopreventive agent supported by strong evidence from epidemiological data; however, the mechanisms are not well understood. The objective of this dissertation is to identify novel …
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Significant Association of ADORA3 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population
INTRODUCTION: Aspirin-intolerant urticaria (AIU) presents with the immediate onset of urticaria after aspirin ingestion persisting for 1 to more than 6 weeks depending upon the severity. Adenosine is a potent and ubiquitous signaling nucleoside that is generated in response to cellular stress and …
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Polymorphisms of High-affinity IgE Receptor Genes in Patients with Aspirin-Intolerant Chronic Urticaria
… Chronic urticaria is commonly associated with aspirin hypersensitivity. Although the mechanism that underlies aspirin hypersensitivity is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU). Atopy was reported a risk …
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Genetic effect of histamine N-methyltransferase (HNMT) polymorphism on chronic urticaria with aspirin hypersensitivity
… susceptibility to develop chronic urticaria with aspirin hypersensitivity. This study investigated the histamine metabolism related gene and functional variability of the HNMT gene according to genetic polymorphisms in chronic urticaria with aspirin hypersensitivity. MATERIALS AND METHODS: We …
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Periodontal conditions in relation to low-dose aspirin therapy in ex- and non-smokers
… of 392 men aged 50 and above with respect to aspirin intake and smoking history. Significant age effects were found on periodontal attachment loss (PAL) but these were of small magnitude in comparison to the significant influences that aspirin and ex-smoking had on PAL
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ROLES OF INOSITOL DIPHOSPHATES IN DNA REPAIR AND EFFECTS OF ASPIRIN ANALOGUES ON OESOPHAGEAL CANCER
… studies have shown that low-dose daily intake of aspirin can decrease the incidence of oesophageal cancer. The data presented in this study show the effects of a number of in-house synthesized novel aspirin analogues on oesophageal cancer cell lines, squamous cell carcinoma (SSC) and …
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